KEGG   DRUG: D08106Help
Entry
D08106                      Drug                                   

Name
Labetalol (INN)
Formula
C19H24N2O3
Exact mass
328.1787
Mol weight
328.4055
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
alfa-Adrenergic blocking;
beta-Adrenergic blocking
Remark
Same as: 
ATC code: 
Drug group: 
Target
alpha1-adrenergic receptor antagonist [HSA:146 147 148] [KO:K04137 K04136 K04135];
beta1-adrenergic receptor antagonist [HSA:153] [KO:K04141];
beta2-adrenergic receptor antagonist [HSA:154] [KO:K04142];
beta3-adrenergic receptor antagonist [HSA:155] [KO:K04143]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
hsa04970  Salivary secretion  
 
Interaction
Drug interaction
Structure map
beta-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C07 BETA BLOCKING AGENTS
   C07A BETA BLOCKING AGENTS
    C07AG Alpha and beta blocking agents
     C07AG01 Labetalol
      D08106  Labetalol (INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Beta-adrenergic Blocking Agents
   Labetalol
    D08106  Labetalol (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor
     Labetalol
      D08106  Labetalol (INN)
    beta1-adrenergic receptor
     Labetalol
      D08106  Labetalol (INN)
    beta2-adrenergic receptor
     Labetalol
      D08106  Labetalol (INN)
    beta3-adrenergic receptor
     Labetalol
      D08106  Labetalol (INN)
BRITE hierarchy
Other DBs
CAS: 
36894-69-6
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        24
            1   C8y C    18.6900  -18.2700
            2   C8y C    18.6900  -19.6700
            3   C8x C    19.8800  -20.3700
            4   C8x C    21.1400  -19.6700
            5   C8y C    21.1400  -18.2700
            6   C8x C    19.8800  -17.5700
            7   C1c C    22.3300  -17.5700
            8   C1b C    23.5900  -18.2700
            9   N1b N    24.7800  -17.5700
            10  C1c C    25.9700  -18.2700
            11  C1b C    27.2300  -17.5700
            12  C1b C    28.4200  -18.2700
            13  C8y C    29.6100  -17.5700
            14  C5a C    17.5000  -17.5700
            15  N1a N    16.3100  -18.2700
            16  O5a O    17.5000  -16.1700
            17  O1a O    17.5000  -20.3700
            18  O1a O    22.3300  -16.1700
            19  C1a C    25.9700  -19.6700
            20  C8x C    30.8700  -18.2700
            21  C8x C    32.0600  -17.5700
            22  C8x C    32.0600  -16.1700
            23  C8x C    30.8700  -15.4700
            24  C8x C    29.6100  -16.1700
BOND        25
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14    1  14 1
            15   14  15 1
            16   14  16 2
            17    2  17 1
            18    7  18 1
            19   10  19 1
            20   13  20 2
            21   20  21 1
            22   21  22 2
            23   22  23 1
            24   23  24 2
            25   13  24 1

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