KEGG   DRUG: LevobunololHelp
Entry
D08115                      Drug                                   

Name
Levobunolol (INN)
Formula
C17H25NO3
Exact mass
291.1834
Mol weight
291.3853
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01466  Adrenergic receptor antagonist
  DG01464  beta-Adrenergic receptor antagonist
   DG01461  beta1-Adrenergic receptor antagonist
   DG01462  beta2-Adrenergic receptor antagonist
   DG01463  beta3-Adrenergic receptor antagonist
Remark
Same as: 
ATC code: 
Chemical group: 
Activity
Antiglaucoma, alpha1/beta-Adrenergic receptor antagonist
Comment
Propranolol derivative
Target
ADRB1 [HSA:153] [KO:K04141];
ADRB2 [HSA:154] [KO:K04142];
ADRB3 [HSA:155] [KO:K04143];
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Gap junction
Salivary secretion
Interaction
Drug interaction
Structure map
Antiglaucoma agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01ED Beta blocking agents
     S01ED03 Levobunolol
      D08115  Levobunolol (INN)
USP drug classification [BR:br08302]
 Ophthalmic Agents
  Ophthalmic Antiglaucoma Agents
   Levobunolol
    D08115  Levobunolol (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    beta1-adrenergic receptor
     Levobunolol
      D08115  Levobunolol (INN)
    beta2-adrenergic receptor
     Levobunolol
      D08115  Levobunolol (INN)
    beta3-adrenergic receptor
     Levobunolol
      D08115  Levobunolol (INN)
BRITE hierarchy
Other DBs
CAS: 
47141-42-4
PubChem: 
ChEBI: 
ChEMBL: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        21
            1   C1d C    25.2700  -14.2800
            2   C1a C    26.4600  -15.0500
            3   N1b N    24.0100  -15.0500
            4   C1b C    22.8200  -14.3500
            5   C1c C    21.6300  -14.9800
            6   C1b C    20.4400  -14.3500
            7   O2a O    19.2500  -14.9800
            8   C1a C    25.2700  -12.8800
            9   C1a C    26.4600  -13.5800
            10  O1a O    21.6300  -16.4500
            11  C8y C    19.2500  -16.3800
            12  C8y C    18.0600  -17.0800
            13  C8y C    18.0600  -18.4800
            14  C8x C    19.2500  -19.2500
            15  C8x C    20.4400  -18.5500
            16  C8x C    20.4400  -17.1500
            17  C1x C    16.8000  -16.3800
            18  C1x C    15.6100  -17.0800
            19  C1x C    15.6100  -18.4800
            20  C5x C    16.8000  -19.2500
            21  O5x O    16.8000  -20.6500
BOND        22
            1     1   2 1
            2     1   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     6   7 1
            7     1   8 1
            8     1   9 1
            9     5  10 1 #Down
            10    7  11 1
            11   11  12 2
            12   12  13 1
            13   13  14 2
            14   14  15 1
            15   15  16 2
            16   11  16 1
            17   12  17 1
            18   17  18 1
            19   18  19 1
            20   19  20 1
            21   13  20 1
            22   20  21 2

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