KEGG   DRUG: D08115Help
Entry
D08115                      Drug                                   

Name
Levobunolol (INN)
Formula
C17H25NO3
Exact mass
291.1834
Mol weight
291.3853
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Glaucoma treatment;
beta1-Adrenergic blocking [DS:H00612]
Remark
Same as: 
ATC code: 
Drug group: 
Target
beta1-adrenergic receptor antagonist [HSA:153] [KO:K04141];
beta2-adrenergic receptor antagonist [HSA:154] [KO:K04142];
beta3-adrenergic receptor antagonist [HSA:155] [KO:K04143];
alpha1-adrenergic receptor antagonist [HSA:146 147 148] [KO:K04137 K04136 K04135]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04144  Endocytosis
hsa04540  Gap junction
hsa04970  Salivary secretion  
 
Interaction
Drug interaction
Structure map
Antiglaucoma agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01ED Beta blocking agents
     S01ED03 Levobunolol
      D08115  Levobunolol (INN)
USP drug classification [BR:br08302]
 Ophthalmic Agents
  Ophthalmic Antiglaucoma Agents
   Levobunolol
    D08115  Levobunolol (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    beta1-adrenergic receptor
     Levobunolol
      D08115  Levobunolol (INN)
    beta2-adrenergic receptor
     Levobunolol
      D08115  Levobunolol (INN)
    beta3-adrenergic receptor
     Levobunolol
      D08115  Levobunolol (INN)
BRITE hierarchy
Other DBs
CAS: 
47141-42-4
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        21
            1   C8y C    21.1400  -18.2700
            2   C8y C    19.8800  -17.5700
            3   C8y C    22.3300  -17.5700
            4   C1x C    21.1400  -19.6700
            5   C8x C    19.8800  -16.1700
            6   C5x C    18.6900  -18.2700
            7   C8x C    22.3300  -16.1700
            8   O2a O    23.5200  -18.2700
            9   C1x C    19.8800  -20.3700
            10  C8x C    21.1400  -15.4700
            11  C1x C    18.6900  -19.6700
            12  O5x O    17.5000  -17.5700
            13  C1b C    24.7100  -17.5700
            14  C1c C    25.9700  -18.2700
            15  C1b C    27.1600  -17.5700
            16  O1a O    25.9700  -19.6700
            17  N1b N    28.3500  -18.2700
            18  C1d C    29.6100  -17.5700
            19  C1a C    30.8000  -18.2700
            20  C1a C    29.6100  -16.1700
            21  C1a C    30.8000  -16.8700
BOND        22
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 1
            9     5  10 1
            10    6  11 1
            11    6  12 2
            12    8  13 1
            13   13  14 1
            14   14  15 1
            15   14  16 1 #Down
            16   15  17 1
            17   17  18 1
            18    7  10 2
            19    9  11 1
            20   18  19 1
            21   18  20 1
            22   18  21 1

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