KEGG   DRUG: D08115Help
Entry
D08115                      Drug                                   

Name
Levobunolol (INN)
Formula
C17H25NO3
Exact mass
291.1834
Mol weight
291.3853
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Glaucoma treatment;
beta1-Adrenergic blocking [DS:H00612]
Remark
Same as: 
ATC code: 
Drug group: 
Target
beta1-adrenergic receptor antagonist [HSA:153] [KO:K04141];
beta2-adrenergic receptor antagonist [HSA:154] [KO:K04142];
beta3-adrenergic receptor antagonist [HSA:155] [KO:K04143];
alpha1-adrenergic receptor antagonist [HSA:146 147 148] [KO:K04137 K04136 K04135]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04144  Endocytosis
hsa04540  Gap junction
hsa04970  Salivary secretion  
 
Structure map
Antiglaucoma agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01ED Beta blocking agents
     S01ED03 Levobunolol
      D08115  Levobunolol (INN)
USP drug classification [BR:br08302]
 Ophthalmic Agents
  Ophthalmic Antiglaucoma Agents
   Levobunolol
    D08115  Levobunolol (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    beta1-adrenergic receptor
     Levobunolol
      D08115  Levobunolol (INN)
    beta2-adrenergic receptor
     Levobunolol
      D08115  Levobunolol (INN)
    beta3-adrenergic receptor
     Levobunolol
      D08115  Levobunolol (INN)
BRITE hierarchy
Other DBs
CAS: 
47141-42-4
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        21
            1   C1d C    25.2700  -14.2800
            2   C1a C    26.4600  -15.0500
            3   N1b N    24.0100  -15.0500
            4   C1b C    22.8200  -14.3500
            5   C1c C    21.6300  -14.9800
            6   C1b C    20.4400  -14.3500
            7   O2a O    19.2500  -14.9800
            8   C1a C    25.2700  -12.8800
            9   C1a C    26.4600  -13.5800
            10  O1a O    21.6300  -16.4500
            11  C8y C    19.2500  -16.3800
            12  C8y C    18.0600  -17.0800
            13  C8y C    18.0600  -18.4800
            14  C8x C    19.2500  -19.2500
            15  C8x C    20.4400  -18.5500
            16  C8x C    20.4400  -17.1500
            17  C1x C    16.8000  -16.3800
            18  C1x C    15.6100  -17.0800
            19  C1x C    15.6100  -18.4800
            20  C5x C    16.8000  -19.2500
            21  O5x O    16.8000  -20.6500
BOND        22
            1     1   2 1
            2     1   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     6   7 1
            7     1   8 1
            8     1   9 1
            9     5  10 1 #Down
            10    7  11 1
            11   11  12 2
            12   12  13 1
            13   13  14 2
            14   14  15 1
            15   15  16 2
            16   11  16 1
            17   12  17 1
            18   17  18 1
            19   18  19 1
            20   19  20 1
            21   13  20 1
            22   20  21 2

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