KEGG   DRUG: D08117Help
Entry
D08117                      Drug                                   

Name
Levocabastine (INN);
Livostin (TN)
Formula
C26H29FN2O2
Exact mass
420.2213
Mol weight
420.5191
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Histamine, H1-receptor antagonist
Remark
ATC code: 
Drug group: 
Target
H1-receptor antagonist [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Structure map
Histamine H1 receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AC Antiallergic agents, excl. corticosteroids
     R01AC02 Levocabastine
      D08117  Levocabastine (INN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01G DECONGESTANTS AND ANTIALLERGICS
    S01GX Other antiallergics
     S01GX02 Levocabastine
      D08117  Levocabastine (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H1-receptor
     Levocabastine
      D08117  Levocabastine (INN)
BRITE hierarchy
Other DBs
CAS: 
79516-68-0
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        31
            1   C8y C    19.4600  -17.7100
            2   C8x C    18.0600  -17.7100
            3   C8x C    17.3600  -18.9000
            4   C8y C    18.0600  -20.0900
            5   C8x C    19.4600  -20.0900
            6   C8x C    20.1600  -18.9000
            7   C8y C    28.8400  -17.7100
            8   C8x C    28.1400  -18.9700
            9   C8x C    28.8400  -20.1600
            10  C8x C    30.2400  -20.1600
            11  C8x C    30.9400  -18.9700
            12  C8x C    30.2400  -17.7800
            13  C1z C    20.7200  -17.0100
            14  C1x C    21.4200  -18.2700
            15  C1x C    22.7500  -18.2700
            16  C1y C    23.4500  -17.0100
            17  C1x C    22.7500  -15.7500
            18  C1x C    21.4200  -15.7500
            19  N1y N    24.8500  -17.0100
            20  C1x C    25.5500  -18.2000
            21  C1x C    26.9500  -18.2000
            22  C1z C    27.6500  -17.0800
            23  C1y C    26.9500  -15.7500
            24  C1x C    25.5500  -15.7500
            25  C6a C    28.8400  -16.3100
            26  C3b C    19.4600  -16.3100
            27  O6a O    29.5400  -15.1200
            28  O6a O    30.1700  -16.7300
            29  X   F    17.3600  -21.2800
            30  N3a N    18.2700  -15.6100
            31  C1a C    27.6500  -14.5600
BOND        34
            1    13  14 1
            2    14  15 1
            3    15  16 1
            4    16  17 1
            5    17  18 1
            6    18  13 1
            7     5   6 2
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12   11  12 2
            13   19  20 1
            14   20  21 1
            15   21  22 1
            16   22  23 1
            17   23  24 1
            18   24  19 1
            19   16  19 1 #Up
            20   12   7 1
            21   22  25 1 #Down
            22    6   1 1
            23   13  26 1 #Up
            24   13   1 1 #Down
            25   22   7 1 #Up
            26    1   2 2
            27   25  27 2
            28    2   3 1
            29   25  28 1
            30    3   4 2
            31    4  29 1
            32    4   5 1
            33   26  30 3
            34   23  31 1 #Up

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