KEGG   DRUG: D08118Help
Entry
D08118                      Drug                                   

Name
Levocetirizine hydrochloride (JAN/USAN);
Levocetirizine dihydrochloride;
Xyzal (TN)
Product
  Generic
LEVOCETIRIZINE DIHYDROCHLORIDE (Aidarex Pharmaceuticals LLC), LEVOCETIRIZINE DIHYDROCHLORIDE (American Health Packaging), LEVOCETIRIZINE DIHYDROCHLORIDE (Bryant Ranch Prepack), LEVOCETIRIZINE DIHYDROCHLORIDE (Camber Pharmaceuticals), LEVOCETIRIZINE DIHYDROCHLORIDE (Dispensing Solutions), LEVOCETIRIZINE DIHYDROCHLORIDE (Dr.Reddy's laboratories), LEVOCETIRIZINE DIHYDROCHLORIDE (Glenmark Generics), LEVOCETIRIZINE DIHYDROCHLORIDE (Lake Erie Medical DBA Quality Care Products LLC), LEVOCETIRIZINE DIHYDROCHLORIDE (Micro Labs Limited), LEVOCETIRIZINE DIHYDROCHLORIDE (PD-Rx Pharmaceuticals), LEVOCETIRIZINE DIHYDROCHLORIDE (Perrigo New York), LEVOCETIRIZINE DIHYDROCHLORIDE (Physicians Total Care), LEVOCETIRIZINE DIHYDROCHLORIDE (ScieGen Pharmaceuticals), LEVOCETIRIZINE DIHYDROCHLORIDE (Sun Pharma Global FZE), LEVOCETIRIZINE DIHYDROCHLORIDE (Synthon Pharmaceuticals), LEVOCETIRIZINE DIHYDROCHLORIDE (Taro Pharmaceuticals U.S.A.), LEVOCETIRIZINE DIHYDROCHLORIDE (Teva Pharmaceuticals USA), LEVOCETIRIZINE DIHYDROCHLORIDE (Vensun Pharmaceuticals)
Formula
C21H25ClN2O3. 2HCl
Exact mass
460.1087
Mol weight
461.8097
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Histamine, H1-receptor antagonist
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
H1-receptor antagonist [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Interaction
Drug interaction
Structure map
Histamine H1 receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AE Piperazine derivatives
     R06AE09 Levocetirizine
      D08118  Levocetirizine hydrochloride (JAN/USAN)
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Antihistamines
   Levocetirizine
    D08118  Levocetirizine hydrochloride (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  44  Allergic agents
   449  Miscellaneous
    4490  Miscellaneous
     D08118  Levocetirizine hydrochloride (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H1-receptor
     Levocetirizine
      D08118  Levocetirizine hydrochloride (JAN)
BRITE hierarchy
Other DBs
CAS: 
130018-87-0
PubChem: 
LigandBox: 
KCF data Show

ATOM        29
            1   C8x C    21.4819  -20.8517
            2   C8y C    21.4819  -22.2511
            3   C8x C    22.7413  -22.9508
            4   C8x C    23.9309  -22.2511
            5   C8y C    23.9309  -20.8517
            6   C8x C    22.7413  -20.1519
            7   C8x C    26.3799  -22.2511
            8   C8y C    26.3799  -20.8517
            9   C1c C    25.1204  -20.1519
            10  C8x C    27.5694  -22.9508
            11  C8x C    28.7589  -22.2511
            12  C8x C    28.7589  -20.8517
            13  C8x C    27.5694  -20.1519
            14  N1y N    25.1204  -18.7525
            15  C1x C    26.3799  -18.0528
            16  C1x C    26.3799  -16.6534
            17  N1y N    25.1204  -15.8837
            18  C1x C    23.9309  -16.6534
            19  C1x C    23.9309  -18.0528
            20  X   Cl   20.2923  -22.9508
            21  C1b C    25.1204  -14.4843
            22  C1b C    26.3799  -13.7845
            23  O2a O    27.5694  -14.4843
            24  C1b C    28.7589  -13.8545
            25  C6a C    29.9484  -14.4843
            26  O6a O    31.1379  -13.8545
            27  O6a O    29.9484  -15.9537
            28  X   Cl   31.9074  -18.9624
            29  X   Cl   31.8376  -21.1315
BOND        29
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   8 1
            8     9   8 1 #Down
            9     5   9 1
            10    7  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14    8  13 2
            15    9  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 1
            19   17  18 1
            20   18  19 1
            21   14  19 1
            22    2  20 1
            23   17  21 1
            24   21  22 1
            25   22  23 1
            26   23  24 1
            27   24  25 1
            28   25  26 1
            29   25  27 2

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