KEGG   DRUG: LevofloxacinHelp
Entry
D08120                      Drug                                   

Name
Levofloxacin (INN);
Cravit (TN);
Levaquin (TN)
Formula
C18H20FN3O4
Exact mass
361.1438
Mol weight
361.3675
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antibacterial
 DG01550  Quinolone
  DG01549  Fluoroquinolone
Other
 DG01529  Topoisomerase inhibitor
  DG01528  Topoisomerase IV inhibitor
Remark
Same as: 
ATC code: 
Chemical group: 
Activity
Antibacterial, Nucleic acid biosynthesis inhibitor
Comment
Fluoroqunolones
Target
DNA gyrase [KO:K02469 K02470];
topoisomerase IV [KO:K02621 K02622]
Metabolism
Transporter: SLCO1A2 [HSA:6579]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01M QUINOLONE ANTIBACTERIALS
    J01MA Fluoroquinolones
     J01MA12 Levofloxacin
      D08120  Levofloxacin (INN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AE Fluoroquinolones
     S01AE05 Levofloxacin
      D08120  Levofloxacin (INN)
USP drug classification [BR:br08302]
 Antibacterials
  Quinolones
   Levofloxacin
    D08120  Levofloxacin (INN)
Antiinfectives [BR:br08307]
 Antibacterials
  Nucleic acid synthesis inhibitor
   type II topoisomerase (DNA gyrase, topoisomerase IV) inhibitor
    Fluoroquinolones
     Levofloxacin
      D08120  Levofloxacin (INN)
Cytochrome P450 interactions [BR:br08309]
 Transporter substrates
  SLCO1A2
   Levofloxacin
    D08120  Levofloxacin (INN)
BRITE hierarchy
Other DBs
CAS: 
100986-85-4
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        26
            1   C8y C    25.4100  -18.2700
            2   C8y C    24.2200  -18.9700
            3   C8y C    25.4100  -16.8700
            4   N4y N    26.6700  -18.9700
            5   C8y C    23.0300  -18.2700
            6   O2x O    24.2200  -20.3700
            7   C8y C    26.6700  -16.1700
            8   C8x C    24.2200  -16.1700
            9   C8x C    27.8600  -18.2700
            10  C1y C    26.6700  -20.3700
            11  N1y N    21.7700  -18.9700
            12  C8y C    23.0300  -16.8700
            13  C1x C    25.4100  -21.0700
            14  C8y C    27.8600  -16.8700
            15  O5x O    26.6700  -14.7700
            16  C1a C    27.8600  -21.0700
            17  C1x C    21.7700  -20.3700
            18  C1x C    20.5800  -18.2700
            19  X   F    21.7700  -16.1700
            20  C6a C    29.0500  -16.1700
            21  C1x C    20.5800  -21.0700
            22  C1x C    19.3900  -18.9700
            23  O6a O    30.2400  -16.8700
            24  O6a O    29.0500  -14.7700
            25  N1y N    19.3900  -20.3700
            26  C1a C    18.1300  -21.0700
BOND        29
            1    25  26 1
            2     8  12 2
            3     9  14 2
            4    10  13 1
            5    22  25 1
            6     1   2 1
            7     1   3 2
            8     1   4 1
            9     2   5 2
            10    2   6 1
            11    3   7 1
            12    3   8 1
            13    4   9 1
            14    4  10 1
            15    5  11 1
            16    5  12 1
            17    6  13 1
            18    7  14 1
            19    7  15 2
            20   10  16 1 #Up
            21   11  17 1
            22   11  18 1
            23   12  19 1
            24   14  20 1
            25   17  21 1
            26   18  22 1
            27   20  23 1
            28   20  24 2
            29   21  25 1

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