KEGG   DRUG: Levomethadone hydrochlorideHelp
Entry
D08122                      Drug                                   

Name
Levomethadone hydrochloride;
L-polamidon (TN)
Formula
C21H27NO. HCl
Exact mass
345.1859
Mol weight
345.9061
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01498  NMDA receptor antagonist
 DG01564  Opioid receptor agonist
  DG01563  mu-Opioid receptor agonist
Analgesic
 DG01984  Opioid analgesics
Other
 DG01718  Drugs for addictive disorder
  DG01717  Drugs for opioid dependence
Cyp substrate
 DG01633  CYP3A substrate
Cyp inhibitor
 DG01645  CYP2D6 inhibitor
Remark
ATC code: N07BC05
Chemical structure group: DG01002
Efficacy
Analgesic, Opioid receptor agonist, NMDA receptor antagonist
Comment
Synthetic opioid
See Methadone [DR:D08195]
Target
OPRM1 [HSA:4988] [KO:K04215]
GRIN (NMDAR) [HSA:2902 2903 2904 2905 2906] [KO:K05208 K05209 K05210 K05211 K05212]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04720  Long-term potentiation
hsa04724  Glutamatergic synapse
Interaction
Drug interaction
Structure map
map07224  Opioid receptor agonists/antagonists
map07235  N-Metyl-D-aspartic acid receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07B DRUGS USED IN ADDICTIVE DISORDERS
    N07BC Drugs used in opioid dependence
     N07BC05 Levomethadone
      D08122  Levomethadone hydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D08122  Levomethadone hydrochloride
 Ion channels
  Ligand-gated ion channels
   Glutamate (ionotropic), NMDA
    GRIN (NMDAR)
     D08122  Levomethadone hydrochloride
BRITE hierarchy
Other DBs
CAS: 5967-73-7
PubChem: 96024812
LigandBox: D08122
NIKKAJI: J231.202F
KCF data Show

ATOM        24
            1   C8x C    21.0000  -19.2500
            2   C8x C    21.0000  -20.6500
            3   C8x C    22.1900  -21.3500
            4   C8x C    23.3800  -20.6500
            5   C8y C    23.3800  -19.2500
            6   C8x C    22.1900  -18.6200
            7   C8x C    25.6900  -20.6500
            8   C8y C    25.6900  -19.2500
            9   C1d C    24.5000  -18.6200
            10  C8x C    26.8800  -21.3500
            11  C8x C    28.0700  -20.6500
            12  C8x C    28.0700  -19.2500
            13  C8x C    26.8800  -18.6200
            14  C1b C    24.5000  -17.2200
            15  C1c C    25.6900  -16.5200
            16  C5a C    22.5400  -17.5000
            17  N1c N    25.6900  -15.2600
            18  C1a C    26.8800  -14.5600
            19  C1a C    24.5000  -14.5600
            20  O5a O    22.5400  -16.1700
            21  C1b C    21.3500  -18.2000
            22  C1a C    20.2300  -17.5000
            23  C1a C    26.8800  -17.2200
            24  X   Cl   31.3600  -17.9900
BOND        24
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   8 1
            8     8   9 1
            9     5   9 1
            10    7  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14    8  13 2
            15    9  14 1
            16   14  15 1
            17    9  16 1
            18   15  17 1
            19   17  18 1
            20   17  19 1
            21   16  20 2
            22   16  21 1
            23   21  22 1
            24   15  23 1 #Down

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