KEGG   DRUG: D08127Help
Entry
D08127                      Drug                                   

Name
Lidocaine hydrochloride monohydrate;
Lidocaine (TN)
Formula
C14H22N2O. HCl. H2O
Exact mass
288.1605
Mol weight
288.8135
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiarrhythmic;
Local anesthetic
Remark
Comment
Class I antiarrhythmic agent (Ib)
Target
voltage-gated sodium channel (SCN1A) blocker [HSA:6323] [KO:K04833];
voltage-gated sodium channel (SCN2A) blocker [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN3A) blocker [HSA:6328] [KO:K04836];
voltage-gated sodium channel (SCN4A) blocker [HSA:6329] [KO:K04837];
voltage-gated sodium channel (SCN5A) blocker [HSA:6331] [KO:K04838];
voltage-gated sodium channel (SCN8A) blocker [HSA:6334] [KO:K04840];
voltage-gated sodium channel (SCN9A) blocker [HSA:6335] [KO:K04841];
voltage-gated sodium channel (SCN10A) blocker [HSA:6336] [KO:K04842]
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP3A4 [HSA:1576], CYP2D6 [HSA:1565]
Transporter: SLC22A3 [HSA:6581]
Interaction
Drug interaction
Structure map
Antiarrhythmic drugs
Sodium channel blocking drugs
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  12  Agents affecting peripheral nervous system
   121  Local anesthetics
    1214  Xylidines
     D08127  Lidocaine hydrochloride monohydrate
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BB Antiarrhythmics, class Ib
     C01BB01 Lidocaine
      D08127  Lidocaine hydrochloride monohydrate
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AD Local anesthetics
     C05AD01 Lidocaine
      D08127  Lidocaine hydrochloride monohydrate
 D DERMATOLOGICALS
  D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
   D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
    D04AB Anesthetics for topical use
     D04AB01 Lidocaine
      D08127  Lidocaine hydrochloride monohydrate
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01B ANESTHETICS, LOCAL
    N01BB Amides
     N01BB02 Lidocaine
      D08127  Lidocaine hydrochloride monohydrate
 R RESPIRATORY SYSTEM
  R02 THROAT PREPARATIONS
   R02A THROAT PREPARATIONS
    R02AD Anesthetics, local
     R02AD02 Lidocaine
      D08127  Lidocaine hydrochloride monohydrate
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01H LOCAL ANESTHETICS
    S01HA Local anesthetics
     S01HA07 Lidocaine
      D08127  Lidocaine hydrochloride monohydrate
  S02 OTOLOGICALS
   S02D OTHER OTOLOGICALS
    S02DA Analgesics and anesthetics
     S02DA01 Lidocaine
      D08127  Lidocaine hydrochloride monohydrate
USP drug classification [BR:br08302]
 Anesthetics
  Local Anesthetics
   Lidocaine
    D08127  Lidocaine hydrochloride monohydrate
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A) [HSA:6323] [KO:K04833]
     Lidocaine [ATC:C01BB01 C05AD01 D04AB01]
      D08127  Lidocaine hydrochloride monohydrate
    voltage-gated sodium channel (SCN2A) [HSA:6326] [KO:K04834]
     Lidocaine [ATC:C01BB01 C05AD01 D04AB01]
      D08127  Lidocaine hydrochloride monohydrate
    voltage-gated sodium channel (SCN3A) [HSA:6328] [KO:K04836]
     Lidocaine [ATC:C01BB01 C05AD01 D04AB01]
      D08127  Lidocaine hydrochloride monohydrate
    voltage-gated sodium channel (SCN4A) [HSA:6329] [KO:K04837]
     Lidocaine [ATC:C01BB01 C05AD01 D04AB01]
      D08127  Lidocaine hydrochloride monohydrate
    voltage-gated sodium channel (SCN5A) [HSA:6331] [KO:K04838]
     Lidocaine [ATC:C01BB01 C05AD01 D04AB01]
      D08127  Lidocaine hydrochloride monohydrate
    voltage-gated sodium channel (SCN8A) [HSA:6334] [KO:K04840]
     Lidocaine [ATC:C01BB01 C05AD01 D04AB01]
      D08127  Lidocaine hydrochloride monohydrate
    voltage-gated sodium channel (SCN9A) [HSA:6335] [KO:K04841]
     Lidocaine [ATC:C01BB01 C05AD01 D04AB01]
      D08127  Lidocaine hydrochloride monohydrate
    voltage-gated sodium channel (SCN10A) [HSA:6336] [KO:K04842]
     Lidocaine [ATC:C01BB01 C05AD01 D04AB01]
      D08127  Lidocaine hydrochloride monohydrate
BRITE hierarchy
Other DBs
CAS: 
6108-05-0
PubChem: 
LigandBox: 
KCF data Show

ATOM        19
            1   C8y C    19.5300  -17.9200
            2   N1b N    20.7200  -18.6200
            3   C8y C    18.2700  -18.6200
            4   C8y C    19.5300  -16.5200
            5   C5a C    21.9800  -17.9200
            6   C8x C    17.0800  -17.9200
            7   C1a C    18.2700  -20.0200
            8   C8x C    18.2700  -15.8200
            9   C1a C    20.7200  -15.8200
            10  C1b C    23.1700  -18.6200
            11  O5a O    21.9800  -16.8700
            12  C8x C    17.0800  -16.5200
            13  N1c N    24.4300  -17.9200
            14  C1b C    25.6900  -18.6200
            15  C1b C    24.4300  -16.5200
            16  C1a C    26.8800  -17.9200
            17  C1a C    25.6900  -15.8200
            18  X   Cl   31.2200  -17.3600
            19  O0  O    31.2900  -14.9100
BOND        17
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     3   7 1
            7     4   8 2
            8     4   9 1
            9     5  10 1
            10    5  11 2
            11    6  12 2
            12   10  13 1
            13   13  14 1
            14   13  15 1
            15   14  16 1
            16   15  17 1
            17    8  12 1

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