KEGG   DRUG: D08132Help
Entry
D08132                      Drug                                   

Name
Lisuride (INN)
Formula
C20H26N4O
Exact mass
338.2107
Mol weight
338.4466
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antimigraine;
Prolactin inhibitor
Remark
ATC code: 
Drug group: 
Target
5-HT1A-receptor agonist [HSA:3350] [KO:K04153];
dopamine D2-receptor agonist [HSA:1813] [KO:K04145]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse  
 
Interaction
Drug interaction
Structure map
Antimigraines
Serotonin receptor agonists/antagonists
Dopamine receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G02 OTHER GYNECOLOGICALS
   G02C OTHER GYNECOLOGICALS
    G02CB Prolactine inhibitors
     G02CB02 Lisuride
      D08132  Lisuride (INN)
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02C ANTIMIGRAINE PREPARATIONS
    N02CA Ergot alkaloids
     N02CA07 Lisuride
      D08132  Lisuride (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    dopamine D2-receptor
     Lisuride
      D08132  Lisuride (INN)
   Serotonin
    5-HT1A-receptor
     Lisuride
      D08132  Lisuride (INN)
BRITE hierarchy
Other DBs
CAS: 
18016-80-3
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        25
            1   C8x C    21.6050  -19.7151
            2   C8x C    21.6050  -21.0434
            3   C8x C    22.7935  -19.0160
            4   C8y C    23.9819  -19.7151
            5   C1x C    26.3589  -21.0434
            6   C2y C    25.1704  -19.0160
            7   C1y C    26.3589  -19.7151
            8   N1y N    27.5473  -19.0160
            9   C1y C    26.3589  -16.9886
            10  C2x C    25.1705  -17.6178
            11  C8y C    23.9819  -21.0434
            12  C8y C    22.7935  -21.7425
            13  N4x N    22.7935  -23.1407
            14  C8x C    25.1704  -23.1408
            15  C8y C    25.1704  -21.7425
            16  N1b N    26.3589  -15.5904
            17  C5a C    27.5473  -14.9612
            18  N1c N    28.7358  -15.6603
            19  C1b C    29.9243  -14.9612
            20  C1a C    28.6659  -19.7151
            21  C1b C    28.7358  -16.9886
            22  C1x C    27.5473  -17.6877
            23  C1a C    29.9243  -17.6877
            24  C1a C    31.1127  -15.6603
            25  O5a O    27.5473  -13.5630
BOND        28
            1    10   6 2
            2     4  11 1
            3    15   5 1
            4     5   7 1
            5     6   4 1
            6    11  12 2
            7    12  13 1
            8    14  15 2
            9    15  11 1
            10   13  14 1
            11    1   2 2
            12    9  16 1 #Down
            13    2  12 1
            14   19  24 1
            15   16  17 1
            16    4   3 2
            17    3   1 1
            18   17  18 1
            19   18  19 1
            20    6   7 1
            21    8  20 1
            22    7   8 1
            23   18  21 1
            24    8  22 1
            25   22   9 1
            26   21  23 1
            27    9  10 1
            28   17  25 2

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