KEGG   DRUG: D08140Help
Entry
D08140                      Drug                                   

Name
Lofepramine (INN)
Formula
C26H27ClN2O
Exact mass
418.1812
Mol weight
418.9584
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antidepressant, tricyclic
Remark
ATC code: 
Comment
Tricyclic antidepressants
Target
serotonin transporter inhibitor [HSA:6532] [KO:K05037];
noradrenalin transporter inhibitor [HSA:6530] [KO:K05035]
  Pathway
hsa04726  Serotonergic synapse  
 
Interaction
Drug interaction
Structure map
Antidepressants
Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AA Non-selective monoamine reuptake inhibitors
     N06AA07 Lofepramine
      D08140  Lofepramine (INN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (noradrenalin transporter) [HSA:6530] [KO:K05035]
     Lofepramine [ATC:N06AA07]
      D08140  Lofepramine (INN)
    SLC6A4 (serotonin transporter) [HSA:6532] [KO:K05037]
     Lofepramine [ATC:N06AA07]
      D08140  Lofepramine (INN)
BRITE hierarchy
Other DBs
CAS: 
23047-25-8
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        30
            1   C1x C    19.9500  -21.2100
            2   C8y C    19.1100  -20.0900
            3   C8y C    19.4600  -18.7600
            4   N1y N    20.7200  -18.2000
            5   C1x C    21.3500  -21.2100
            6   C8y C    21.9800  -18.8300
            7   C8y C    22.2600  -20.1600
            8   C8x C    18.4100  -17.7800
            9   C8x C    17.0800  -18.2000
            10  C8x C    16.7300  -19.5300
            11  C8x C    17.7800  -20.5100
            12  C8x C    23.5900  -20.5800
            13  C8x C    24.6400  -19.6700
            14  C8x C    24.3600  -18.2700
            15  C8x C    23.0300  -17.8500
            16  C1b C    20.7200  -16.8000
            17  C1b C    21.9100  -16.1000
            18  C1b C    23.1000  -16.7300
            19  N1c N    24.2900  -16.1000
            20  C1b C    25.5500  -16.7300
            21  C5a C    26.7400  -16.1000
            22  C8y C    27.9300  -16.7300
            23  O5a O    26.7400  -14.6300
            24  C1a C    24.2900  -14.6300
            25  C8x C    27.9300  -18.2000
            26  C8x C    29.1200  -18.9000
            27  C8y C    30.3100  -18.2000
            28  C8x C    30.3100  -16.7300
            29  C8x C    29.1200  -16.0300
            30  X   Cl   31.5700  -18.9000
BOND        33
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    7  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17    6  15 2
            18    4  16 1
            19   16  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1
            23   20  21 1
            24   21  22 1
            25   21  23 2
            26   19  24 1
            27   22  25 2
            28   25  26 1
            29   26  27 2
            30   27  28 1
            31   28  29 2
            32   22  29 1
            33   27  30 1

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