KEGG   DRUG: D08144Help
Entry
D08144                      Drug                                   

Name
Loperamide (INN);
Diamide (TN)
Formula
C29H33ClN2O2
Exact mass
476.2231
Mol weight
477.0375
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antidiarrhoeal
Remark
Same as: 
ATC code: 
Drug group: 
Target
mu-opioid receptor agonist [HSA:4988] [KO:K04215]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Metabolism
Transporter: ABCB1 [HSA:5243]
Interaction
Drug interaction
Other map
Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07D ANTIPROPULSIVES
    A07DA Antipropulsives
     A07DA03 Loperamide
      D08144  Loperamide (INN)
USP drug classification [BR:br08302]
 Gastrointestinal Agents
  Gastrointestinal Agents, Other
   Loperamide
    D08144  Loperamide (INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Specified Category 2
  Inorganic and organic chemicals
   Loperamide
    D08144  Loperamide (INN)
 Category 2
  Inorganic and organic chemicals
   Loperamide
    D08144  Loperamide (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    mu-opioid receptor
     Loperamide
      D08144  Loperamide (INN)
BRITE hierarchy
Other DBs
CAS: 
53179-11-6
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        34
            1   C8x C    21.7000  -23.1700
            2   C8x C    21.7000  -24.5000
            3   C8x C    22.8900  -25.2000
            4   C8x C    24.0800  -24.5000
            5   C8y C    24.0800  -23.1700
            6   C8x C    22.8900  -22.5400
            7   C8x C    26.3900  -24.5000
            8   C8y C    26.3900  -23.1700
            9   C1d C    25.2000  -22.5400
            10  C8x C    27.5800  -25.2000
            11  C8x C    28.7000  -24.5000
            12  C8x C    28.7000  -23.1700
            13  C8x C    27.5800  -22.5400
            14  C5a C    21.9800  -20.8600
            15  N1c N    20.8600  -21.5600
            16  O5a O    21.9800  -19.5300
            17  C1b C    25.2000  -21.1400
            18  C1b C    26.4600  -20.4400
            19  N1y N    26.4600  -19.0400
            20  C1x C    27.6500  -18.3400
            21  C1x C    27.6500  -16.9400
            22  C1z C    26.4600  -16.2400
            23  C1x C    25.2000  -16.9400
            24  C1x C    25.2000  -18.3400
            25  C1a C    19.6000  -20.9300
            26  C1a C    20.8600  -22.9600
            27  C8y C    26.4600  -14.8400
            28  C8x C    27.7200  -14.1400
            29  C8x C    27.7200  -12.7400
            30  C8y C    26.5300  -12.0400
            31  C8x C    25.2700  -12.7400
            32  C8x C    25.2700  -14.1400
            33  O1a O    27.6500  -15.5400
            34  X   Cl   26.5300  -10.6400
BOND        37
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   8 1
            8     8   9 1
            9     5   9 1
            10    7  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14    8  13 2
            15    9  14 1
            16   14  15 1
            17   14  16 2
            18    9  17 1
            19   17  18 1
            20   18  19 1
            21   19  20 1
            22   20  21 1
            23   21  22 1
            24   22  23 1
            25   23  24 1
            26   19  24 1
            27   15  25 1
            28   15  26 1
            29   22  27 1
            30   27  28 2
            31   28  29 1
            32   29  30 2
            33   30  31 1
            34   31  32 2
            35   27  32 1
            36   22  33 1
            37   30  34 1

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