KEGG   DRUG: D08146Help
Entry
D08146                      Drug                                   

Name
Losartan (INN);
Losartic (TN)
Formula
C22H23ClN6O
Exact mass
422.1622
Mol weight
422.9106
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Angiotensin II antagonist;
Antihypertensive
Remark
Same as: 
ATC code: 
Target
angiotensin II receptor type 1 (AT1) antagonist [HSA:185] [KO:K04166]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04614  Renin-angiotensin system  
 
Metabolism
Enzyme: CYP2C9 [HSA:1559], CYP3A4 [HSA:1576]
Interaction
Transporter inhibition: URAT1 [HSA:116085], ABCB11 (BSEP) [HSA:8647]
Drug interaction
Structure map
Angiotensin receptor and endothelin receptor antagonists
Other map
Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
   C09C ANGIOTENSIN II ANTAGONISTS, PLAIN
    C09CA Angiotensin II antagonists, plain
     C09CA01 Losartan
      D08146  Losartan (INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Angiotensin II Receptor Antagonists
   Losartan
    D08146  Losartan (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Angiotensin
    angiotensin II stimulates angiotensin subtype 1 (AT1) receptor [HSA:185] [KO:K04166]
     Losartan [ATC:C09CA01]
      D08146  Losartan (INN)
BRITE hierarchy
Other DBs
CAS: 
114798-26-4
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        30
            1   N4y N    28.8231  -16.7197
            2   C8y C    29.2429  -18.0488
            3   C8y C    29.9424  -15.8802
            4   C1b C    27.5639  -16.0201
            5   N5x N    30.6420  -18.0488
            6   C1b C    28.4034  -19.1681
            7   C8y C    31.0617  -16.7197
            8   C1b C    29.9424  -14.4811
            9   C8y C    26.3747  -16.7896
            10  C1b C    28.9630  -20.4273
            11  X   Cl   32.3909  -16.2999
            12  O1a O    31.1317  -13.7815
            13  C8x C    26.3747  -18.1887
            14  C8x C    25.1854  -16.0901
            15  C1b C    28.1935  -21.5466
            16  C8x C    25.1854  -18.8883
            17  C8x C    23.9962  -16.8596
            18  C1a C    28.7532  -22.8758
            19  C8y C    23.9962  -18.1887
            20  C8y C    22.7369  -18.8883
            21  C8y C    21.5477  -18.2587
            22  C8x C    22.7370  -20.2874
            23  C8y C    21.5477  -16.8596
            24  C8x C    20.3585  -18.9583
            25  C8x C    21.6177  -20.9870
            26  N4x N    20.4284  -16.0201
            27  N5x N    22.7370  -16.0201
            28  C8x C    20.3585  -20.3573
            29  N5x N    20.8482  -14.6910
            30  N5x N    22.2473  -14.6910
BOND        33
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 1
            9     6  10 1
            10    7  11 1
            11    8  12 1
            12    9  13 2
            13    9  14 1
            14   10  15 1
            15   13  16 1
            16   14  17 2
            17   15  18 1
            18   16  19 2
            19   19  20 1
            20   20  21 1
            21   20  22 2
            22   21  23 1
            23   21  24 2
            24   22  25 1
            25   23  26 1
            26   23  27 2
            27   24  28 1
            28   26  29 1
            29   27  30 1
            30    5   7 1
            31   17  19 1
            32   25  28 2
            33   29  30 2

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