KEGG   DRUG: LosartanHelp
Entry
D08146                      Drug                                   

Name
Losartan (INN);
Losartic (TN)
Formula
C22H23ClN6O
Exact mass
422.1622
Mol weight
422.9106
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01495  Angiotensin II receptor antagonist
Cyp substrate
 DG01633  CYP3A4 substrate
Unclassified
 DG01925  Renin-angiotensin system inhibitor
  DG01495  Angiotensin II receptor antagonist
Remark
Same as: 
ATC code: 
Chemical group: 
Activity
Antihypertensive, Angiotensin II receptor antagonist
Target
angiotensin II receptor type 1 (AT1) [HSA:185] [KO:K04166]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Renin-angiotensin system
Metabolism
Enzyme: CYP2C9 [HSA:1559], CYP3A4 [HSA:1576]
Interaction
Transporter inhibition: URAT1 [HSA:116085], ABCB11 [HSA:8647]
Drug interaction
Structure map
Angiotensin receptor and endothelin receptor antagonists
Other map
Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
   C09C ANGIOTENSIN II ANTAGONISTS, PLAIN
    C09CA Angiotensin II antagonists, plain
     C09CA01 Losartan
      D08146  Losartan (INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Angiotensin II Receptor Antagonists
   Losartan
    D08146  Losartan (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Angiotensin
    angiotensin II stimulates angiotensin subtype 1 (AT1) receptor
     Losartan
      D08146  Losartan (INN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP2C9
   Losartan
    D08146  Losartan (INN)
  CYP3A4
   Losartan
    D08146  Losartan (INN)
 Transporter inhibitors
  ABCB11
   Losartan
    D08146  Losartan (INN)
  URAT1
   Losartan
    D08146  Losartan (INN)
BRITE hierarchy
Other DBs
CAS: 
114798-26-4
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        30
            1   N4y N    28.8231  -16.7197
            2   C8y C    29.2429  -18.0488
            3   C8y C    29.9424  -15.8802
            4   C1b C    27.5639  -16.0201
            5   N5x N    30.6420  -18.0488
            6   C1b C    28.4034  -19.1681
            7   C8y C    31.0617  -16.7197
            8   C1b C    29.9424  -14.4811
            9   C8y C    26.3747  -16.7896
            10  C1b C    28.9630  -20.4273
            11  X   Cl   32.3909  -16.2999
            12  O1a O    31.1317  -13.7815
            13  C8x C    26.3747  -18.1887
            14  C8x C    25.1854  -16.0901
            15  C1b C    28.1935  -21.5466
            16  C8x C    25.1854  -18.8883
            17  C8x C    23.9962  -16.8596
            18  C1a C    28.7532  -22.8758
            19  C8y C    23.9962  -18.1887
            20  C8y C    22.7369  -18.8883
            21  C8y C    21.5477  -18.2587
            22  C8x C    22.7370  -20.2874
            23  C8y C    21.5477  -16.8596
            24  C8x C    20.3585  -18.9583
            25  C8x C    21.6177  -20.9870
            26  N4x N    20.4284  -16.0201
            27  N5x N    22.7370  -16.0201
            28  C8x C    20.3585  -20.3573
            29  N5x N    20.8482  -14.6910
            30  N5x N    22.2473  -14.6910
BOND        33
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 1
            9     6  10 1
            10    7  11 1
            11    8  12 1
            12    9  13 2
            13    9  14 1
            14   10  15 1
            15   13  16 1
            16   14  17 2
            17   15  18 1
            18   16  19 2
            19   19  20 1
            20   20  21 1
            21   20  22 2
            22   21  23 1
            23   21  24 2
            24   22  25 1
            25   23  26 1
            26   23  27 2
            27   24  28 1
            28   26  29 1
            29   27  30 1
            30    5   7 1
            31   17  19 1
            32   25  28 2
            33   29  30 2

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