| Entry |
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| Name |
Losartan (INN);
Losartic (TN)
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| Formula |
C22H23ClN6O
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| Exact mass |
422.1622
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| Mol weight |
422.9106
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| Structure |
     |
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| Activity |
Angiotensin II antagonist;
Antihypertensive
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| Remark |
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| Target |
angiotensin II receptor type 1 (AT1) antagonist [HSA: 185] [KO: K04166] |
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| Pathway |
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| Metabolism |
Enzyme: CYP2C9 [HSA: 1559], CYP3A4 [HSA: 1576]
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| Interaction |
Transporter inhibition: URAT1 [HSA: 116085], ABCB11 (BSEP) [HSA: 8647]
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| Pathway map |
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| Structure map |
| Angiotensin receptor and endothelin receptor antagonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
C09C ANGIOTENSIN II ANTAGONISTS, PLAIN
C09CA Angiotensin II antagonists, plain
C09CA01 Losartan
D08146 Losartan (INN)
USP drug classification [BR:br08302]
Cardiovascular Agents
Angiotensin II Receptor Antagonists
Losartan
D08146 Losartan (INN)
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Angiotensin
angiotensin II stimulates angiotensin subtype 1 (AT1) receptor [HSA:185] [KO:K04166]
Losartan [ATC:C09CA01]
D08146 Losartan (INN)
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| Other DBs |
CAS: 114798-26-4 PubChem: DrugBank: LigandBox: NIKKAJI: |
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| KCF data |
ATOM 30
1 N4y N 28.8231 -16.7197
2 C8y C 29.2429 -18.0488
3 C8y C 29.9424 -15.8802
4 C1b C 27.5639 -16.0201
5 N5x N 30.6420 -18.0488
6 C1b C 28.4034 -19.1681
7 C8y C 31.0617 -16.7197
8 C1b C 29.9424 -14.4811
9 C8y C 26.3747 -16.7896
10 C1b C 28.9630 -20.4273
11 X Cl 32.3909 -16.2999
12 O1a O 31.1317 -13.7815
13 C8x C 26.3747 -18.1887
14 C8x C 25.1854 -16.0901
15 C1b C 28.1935 -21.5466
16 C8x C 25.1854 -18.8883
17 C8x C 23.9962 -16.8596
18 C1a C 28.7532 -22.8758
19 C8y C 23.9962 -18.1887
20 C8y C 22.7369 -18.8883
21 C8y C 21.5477 -18.2587
22 C8x C 22.7370 -20.2874
23 C8y C 21.5477 -16.8596
24 C8x C 20.3585 -18.9583
25 C8x C 21.6177 -20.9870
26 N4x N 20.4284 -16.0201
27 N5x N 22.7370 -16.0201
28 C8x C 20.3585 -20.3573
29 N5x N 20.8482 -14.6910
30 N5x N 22.2473 -14.6910
BOND 33
1 1 2 1
2 1 3 1
3 1 4 1
4 2 5 2
5 2 6 1
6 3 7 2
7 3 8 1
8 4 9 1
9 6 10 1
10 7 11 1
11 8 12 1
12 9 13 2
13 9 14 1
14 10 15 1
15 13 16 1
16 14 17 2
17 15 18 1
18 16 19 2
19 19 20 1
20 20 21 1
21 20 22 2
22 21 23 1
23 21 24 2
24 22 25 1
25 23 26 1
26 23 27 2
27 24 28 1
28 26 29 1
29 27 30 1
30 5 7 1
31 17 19 1
32 25 28 2
33 29 30 2
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