KEGG   DRUG: D08155Help
Entry
D08155                      Drug                                   

Name
Manidipine (INN);
Manidipine 6300;
Artedil (TN)
Formula
C35H38N4O6
Exact mass
610.2791
Mol weight
610.6994
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Calcium antagonist
Remark
ATC code: 
Target
calcium channel L type blocker [HSA:775 776 778 779] [KO:K04850 K04851 K04853 K04857]
  Pathway
hsa04010  MAPK signaling pathway
hsa04020  Calcium signaling pathway
hsa04260  Cardiac muscle contraction
hsa04270  Vascular smooth muscle contraction  
 
Interaction
Drug interaction
Structure map
Calcium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C08 CALCIUM CHANNEL BLOCKERS
   C08C SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
    C08CA Dihydropyridine derivatives
     C08CA11 Manidipine
      D08155  Manidipine (INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Ca2+ channel, CACN alpha-1, CaVx.x
    calcium channel L type [HSA:775 776 778 779] [KO:K04850 K04851 K04853 K04857]
     Manidipine [ATC:C08CA11]
      D08155  Manidipine (INN)
BRITE hierarchy
Other DBs
CAS: 
120092-68-4
PubChem: 
LigandBox: 
KCF data Show

ATOM        45
            1   C8x C    18.1300  -19.6700
            2   C8x C    18.1300  -18.2700
            3   C8y C    19.3900  -17.5700
            4   C8x C    20.5800  -18.2700
            5   C8y C    20.5800  -19.6700
            6   C8x C    19.3900  -20.3700
            7   C1y C    19.3900  -16.1700
            8   C2y C    18.1300  -15.4700
            9   C2y C    18.1300  -14.0700
            10  N1x N    19.3900  -13.3700
            11  C2y C    20.5800  -14.0700
            12  C2y C    20.5800  -15.4700
            13  C7a C    21.7700  -16.1700
            14  O7a O    23.0300  -15.4700
            15  C1b C    24.2200  -16.1700
            16  C1b C    25.4100  -15.4700
            17  N1y N    26.6700  -16.1700
            18  C1x C    27.8600  -15.4700
            19  C1x C    29.0500  -16.1700
            20  N1y N    29.0500  -17.5700
            21  C1x C    27.8600  -18.2700
            22  C1x C    26.6700  -17.5700
            23  O6a O    21.7700  -17.5700
            24  C1c C    30.3100  -18.2700
            25  C8y C    31.5000  -17.5700
            26  C8y C    30.3100  -19.6700
            27  C8x C    31.5000  -20.3700
            28  C8x C    31.5000  -21.7700
            29  C8x C    30.2400  -22.4700
            30  C8x C    29.0500  -21.7700
            31  C8x C    29.0500  -20.3700
            32  C8x C    31.5000  -16.1700
            33  C8x C    32.6900  -15.4700
            34  C8x C    33.8800  -16.1700
            35  C8x C    33.8800  -17.5700
            36  C8x C    32.6900  -18.2700
            37  C1a C    21.7700  -13.3700
            38  C1a C    16.9400  -13.3700
            39  C7a C    16.9400  -16.1700
            40  O6a O    16.9400  -17.5700
            41  O7a O    15.7500  -15.4700
            42  C1a C    14.4900  -16.1700
            43  N2b N    21.7700  -20.3700 #+
            44  O3a O    23.0300  -19.6700
            45  O3a O    21.7700  -21.7700 #-
BOND        49
            1    21  22 1
            2    22  17 1
            3     7   8 1
            4    13  23 2
            5     8   9 2
            6    20  24 1
            7     9  10 1
            8    24  25 1
            9    10  11 1
            10   24  26 1
            11   11  12 2
            12   12   7 1
            13    4   5 1
            14   12  13 1
            15    5   6 2
            16   26  27 2
            17   27  28 1
            18   28  29 2
            19   29  30 1
            20   30  31 2
            21   31  26 1
            22   13  14 1
            23    6   1 1
            24   14  15 1
            25   15  16 1
            26   25  32 2
            27   32  33 1
            28   33  34 2
            29   34  35 1
            30   35  36 2
            31   36  25 1
            32    3   7 1
            33   11  37 1
            34   16  17 1
            35    9  38 1
            36    8  39 1
            37   39  40 2
            38    1   2 2
            39   39  41 1
            40    2   3 1
            41   41  42 1
            42    3   4 2
            43    5  43 1
            44   17  18 1
            45   43  44 2
            46   18  19 1
            47   43  45 1
            48   19  20 1
            49   20  21 1

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