KEGG   DRUG: D08155Help
Entry
D08155                      Drug                                   

Name
Manidipine (INN);
Manidipine 6300;
Artedil (TN)
Formula
C35H38N4O6
Exact mass
610.2791
Mol weight
610.6994
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Calcium antagonist
Remark
ATC code: 
Drug group: 
Target
calcium channel L type blocker [HSA:775 776 778 779] [KO:K04850 K04851 K04853 K04857]
  Pathway
hsa04010  MAPK signaling pathway
hsa04020  Calcium signaling pathway
hsa04260  Cardiac muscle contraction
hsa04270  Vascular smooth muscle contraction  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Calcium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C08 CALCIUM CHANNEL BLOCKERS
   C08C SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
    C08CA Dihydropyridine derivatives
     C08CA11 Manidipine
      D08155  Manidipine (INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Ca2+ channel, CACN alpha-1, CaVx.x
    calcium channel L type
     Manidipine
      D08155  Manidipine (INN)
BRITE hierarchy
Other DBs
CAS: 
120092-68-4
PubChem: 
LigandBox: 
KCF data Show

ATOM        45
            1   C8x C    18.1300  -19.6700
            2   C8x C    18.1300  -18.2700
            3   C8y C    19.3900  -17.5700
            4   C8x C    20.5800  -18.2700
            5   C8y C    20.5800  -19.6700
            6   C8x C    19.3900  -20.3700
            7   C1y C    19.3900  -16.1700
            8   C2y C    18.1300  -15.4700
            9   C2y C    18.1300  -14.0700
            10  N1x N    19.3900  -13.3700
            11  C2y C    20.5800  -14.0700
            12  C2y C    20.5800  -15.4700
            13  C7a C    21.7700  -16.1700
            14  O7a O    23.0300  -15.4700
            15  C1b C    24.2200  -16.1700
            16  C1b C    25.4100  -15.4700
            17  N1y N    26.6700  -16.1700
            18  C1x C    27.8600  -15.4700
            19  C1x C    29.0500  -16.1700
            20  N1y N    29.0500  -17.5700
            21  C1x C    27.8600  -18.2700
            22  C1x C    26.6700  -17.5700
            23  O6a O    21.7700  -17.5700
            24  C1c C    30.3100  -18.2700
            25  C8y C    31.5000  -17.5700
            26  C8y C    30.3100  -19.6700
            27  C8x C    31.5000  -20.3700
            28  C8x C    31.5000  -21.7700
            29  C8x C    30.2400  -22.4700
            30  C8x C    29.0500  -21.7700
            31  C8x C    29.0500  -20.3700
            32  C8x C    31.5000  -16.1700
            33  C8x C    32.6900  -15.4700
            34  C8x C    33.8800  -16.1700
            35  C8x C    33.8800  -17.5700
            36  C8x C    32.6900  -18.2700
            37  C1a C    21.7700  -13.3700
            38  C1a C    16.9400  -13.3700
            39  C7a C    16.9400  -16.1700
            40  O6a O    16.9400  -17.5700
            41  O7a O    15.7500  -15.4700
            42  C1a C    14.4900  -16.1700
            43  N2b N    21.7700  -20.3700 #+
            44  O3a O    23.0300  -19.6700
            45  O3a O    21.7700  -21.7700 #-
BOND        49
            1    21  22 1
            2    22  17 1
            3     7   8 1
            4    13  23 2
            5     8   9 2
            6    20  24 1
            7     9  10 1
            8    24  25 1
            9    10  11 1
            10   24  26 1
            11   11  12 2
            12   12   7 1
            13    4   5 1
            14   12  13 1
            15    5   6 2
            16   26  27 2
            17   27  28 1
            18   28  29 2
            19   29  30 1
            20   30  31 2
            21   31  26 1
            22   13  14 1
            23    6   1 1
            24   14  15 1
            25   15  16 1
            26   25  32 2
            27   32  33 1
            28   33  34 2
            29   34  35 1
            30   35  36 2
            31   36  25 1
            32    3   7 1
            33   11  37 1
            34   16  17 1
            35    9  38 1
            36    8  39 1
            37   39  40 2
            38    1   2 2
            39   39  41 1
            40    2   3 1
            41   41  42 1
            42    3   4 2
            43    5  43 1
            44   17  18 1
            45   43  44 2
            46   18  19 1
            47   43  45 1
            48   19  20 1
            49   20  21 1

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