| Entry |
|
|---|
| Name |
Meclozine (BAN);
Meclizine;
Nevidoxine (TN) |
|---|
| Formula |
C25H27ClN2
|
|---|
| Exact mass |
390.1863
|
|---|
| Mol weight |
390.9483
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
|
|---|
| Remark |
| Product (DG01106): | D01317<US> |
|
|---|
| Efficacy |
Anti-emetic, H1 receptor antagonist |
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04750 | Inflammatory mediator regulation of TRP channels |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07212 | Histamine H1 receptor antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
R RESPIRATORY SYSTEM
R06 ANTIHISTAMINES FOR SYSTEMIC USE
R06A ANTIHISTAMINES FOR SYSTEMIC USE
R06AE Piperazine derivatives
R06AE05 Meclozine
D08163 Meclozine (BAN)
Risk category of Japanese OTC drugs [BR:br08312]
Second-class OTC drugs
Inorganic and organic chemicals
Meclizine hydrochloride
D08163 Meclozine (BAN)
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG01106 Meclozine
D08163 Meclozine
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Histamine
HRH1
D08163 Meclozine (BAN)
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG01106 Meclozine
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 28
1 C8x C 20.5100 -21.4200
2 C8y C 20.5100 -22.8200
3 C8x C 21.7000 -23.5200
4 C8x C 22.9600 -22.8200
5 C8y C 22.9600 -21.4200
6 C8x C 21.7000 -20.7200
7 C8x C 25.3400 -22.8200
8 C8y C 25.3400 -21.4200
9 C1c C 24.1500 -20.7200
10 C8x C 26.6000 -23.5200
11 C8x C 27.7900 -22.8200
12 C8x C 27.7900 -21.4200
13 C8x C 26.6000 -20.7200
14 N1y N 24.1500 -19.3200
15 C1x C 25.3400 -18.6200
16 C1x C 25.3400 -17.2200
17 N1y N 24.1500 -16.5200
18 C1x C 22.9600 -17.2200
19 C1x C 22.9600 -18.6200
20 C1b C 24.1500 -15.1200
21 C8y C 25.3400 -14.4200
22 C8x C 26.5300 -15.1200
23 C8y C 27.7900 -14.4200
24 C8x C 27.7900 -13.0200
25 C8x C 26.6000 -12.3200
26 C8x C 25.3400 -13.0200
27 C1a C 28.9800 -15.1200
28 X Cl 19.3200 -23.5200
BOND 31
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 7 8 1
8 8 9 1
9 5 9 1
10 7 10 2
11 10 11 1
12 11 12 2
13 12 13 1
14 8 13 2
15 9 14 1
16 14 15 1
17 15 16 1
18 16 17 1
19 17 18 1
20 18 19 1
21 14 19 1
22 17 20 1
23 20 21 1
24 21 22 2
25 22 23 1
26 23 24 2
27 24 25 1
28 25 26 2
29 21 26 1
30 23 27 1
31 2 28 1
|
|---|
