KEGG   DRUG: D08163Help
Entry
D08163                      Drug                                   

Name
Meclozine (BAN);
Meclizine;
Nevidoxine (TN)
Formula
C25H27ClN2
Exact mass
390.1863
Mol weight
390.9483
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiemetic;
H1-receptor antagonist
Remark
Same as: 
ATC code: 
Target
H1-receptor antagonist [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Structure map
Histamine H1 receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AE Piperazine derivatives
     R06AE05 Meclozine
      D08163  Meclozine (BAN)
USP drug classification [BR:br08302]
 Antiemetics
  Antiemetics, Other
   Meclizine
    D08163  Meclozine (BAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H1-receptor [HSA:3269] [KO:K04149]
     Meclozine [ATC:R06AE05]
      D08163  Meclozine (BAN)
BRITE hierarchy
Other DBs
CAS: 
569-65-3
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        28
            1   C8x C    20.5100  -21.4200
            2   C8y C    20.5100  -22.8200
            3   C8x C    21.7000  -23.5200
            4   C8x C    22.9600  -22.8200
            5   C8y C    22.9600  -21.4200
            6   C8x C    21.7000  -20.7200
            7   C8x C    25.3400  -22.8200
            8   C8y C    25.3400  -21.4200
            9   C1c C    24.1500  -20.7200
            10  C8x C    26.6000  -23.5200
            11  C8x C    27.7900  -22.8200
            12  C8x C    27.7900  -21.4200
            13  C8x C    26.6000  -20.7200
            14  N1y N    24.1500  -19.3200
            15  C1x C    25.3400  -18.6200
            16  C1x C    25.3400  -17.2200
            17  N1y N    24.1500  -16.5200
            18  C1x C    22.9600  -17.2200
            19  C1x C    22.9600  -18.6200
            20  C1b C    24.1500  -15.1200
            21  C8y C    25.3400  -14.4200
            22  C8x C    26.5300  -15.1200
            23  C8y C    27.7900  -14.4200
            24  C8x C    27.7900  -13.0200
            25  C8x C    26.6000  -12.3200
            26  C8x C    25.3400  -13.0200
            27  C1a C    28.9800  -15.1200
            28  X   Cl   19.3200  -23.5200
BOND        31
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   8 1
            8     8   9 1
            9     5   9 1
            10    7  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14    8  13 2
            15    9  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 1
            19   17  18 1
            20   18  19 1
            21   14  19 1
            22   17  20 1
            23   20  21 1
            24   21  22 2
            25   22  23 1
            26   23  24 2
            27   24  25 1
            28   25  26 2
            29   21  26 1
            30   23  27 1
            31    2  28 1

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