KEGG   DRUG: D08174Help
Entry
D08174                      Drug                                   

Name
Memantine (INN);
Exiba (TN)
Formula
C12H21N
Exact mass
179.1674
Mol weight
179.3018
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anti-Alzheimer's [DS:H00056]
Remark
Same as: 
ATC code: 
Drug group: 
Comment
Indication: Alzheimer's disease
adamantane derivative
Target
N-methyl-D-aspartate receptor antagonist [HSA:2902 2903 2904 2905 2906] [KO:K05208 K05209 K05210 K05211 K05212]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04724  Glutamatergic synapse
hsa05010  Alzheimer's disease  
 
Metabolism
Transporter: SLC22A2 [HSA:6582]
Interaction
Drug interaction
Structure map
Agents for Alzheimer-type dementia
N-Metyl-D-aspartic acid receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06D ANTI-DEMENTIA DRUGS
    N06DX Other anti-dementia drugs
     N06DX01 Memantine
      D08174  Memantine (INN)
USP drug classification [BR:br08302]
 Antidementia Agents
  N-methyl-D-aspartate (NMDA) Receptor Antagonist
   Memantine
    D08174  Memantine (INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Glutamate-gated cation channels
   Glutamate (ionotropic), NMDA
    N-methyl-D-aspartate receptor
     Memantine
      D08174  Memantine (INN)
BRITE hierarchy
Other DBs
CAS: 
19982-08-2
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        13
            1   C1x C    22.9600  -17.6400
            2   C1z C    22.9600  -18.9700
            3   C1x C    24.1500  -19.6700
            4   C1z C    25.3400  -18.9700
            5   C1x C    25.3400  -17.6400
            6   C1z C    24.1500  -16.9400
            7   C1x C    22.0500  -19.9500
            8   C1y C    23.3800  -19.9500
            9   C1x C    24.7100  -20.3000
            10  C1a C    26.6700  -19.3200
            11  C1a C    21.7000  -19.3200
            12  N1a N    24.1500  -15.6100
            13  C1x C    23.3800  -18.3400
BOND        15
            1     2   7 1
            2     1   2 1
            3     7   8 1
            4     2   3 1
            5     8   9 1
            6     9   4 1
            7     3   4 1
            8     4  10 1
            9     4   5 1
            10    2  11 1
            11    5   6 1
            12    6  12 1
            13    6   1 1
            14    8  13 1
            15    6  13 1

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