KEGG   DRUG: D08209Help
Entry
D08209                      Drug                                   

Name
Metixene (INN)
Formula
C20H23NS
Exact mass
309.1551
Mol weight
309.4683
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiperkinsonian, central anticholinergic
Remark
ATC code: 
Drug group: 
Target
muscarinic cholinergic receptor antagonist [HSA:1128 1129 1131 1132 1133] [KO:K04129 K04130 K04131 K04132 K04133]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa04970  Salivary secretion
hsa04971  Gastric acid secretion  
 
Interaction
Drug interaction
Structure map
Antiparkinsonian agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N04 ANTI-PARKINSON DRUGS
   N04A ANTICHOLINERGIC AGENTS
    N04AA Tertiary amines
     N04AA03 Metixene
      D08209  Metixene (INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Metixene
    D08209  Metixene (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    muscarinic cholinergic receptor
     Metixene
      D08209  Metixene (INN)
BRITE hierarchy
Other DBs
CAS: 
4969-02-2
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        22
            1   C8x C    19.0400  -19.2500
            2   C8x C    19.0400  -20.6500
            3   C8x C    20.3000  -21.4200
            4   C8x C    20.3000  -18.5500
            5   C8y C    21.4900  -19.2500
            6   C8y C    21.4900  -20.6500
            7   S2x S    22.6800  -21.4200
            8   C1y C    22.6800  -18.6200
            9   C8y C    23.9400  -19.3200
            10  C8y C    23.9400  -20.7200
            11  C8x C    25.1300  -21.4200
            12  C8x C    26.3200  -20.7200
            13  C8x C    26.3200  -19.3200
            14  C8x C    25.1300  -18.6200
            15  C1b C    22.6800  -17.2200
            16  C1y C    23.9400  -16.5200
            17  C1x C    25.1300  -17.2200
            18  N1y N    26.3200  -16.5200
            19  C1x C    26.3200  -15.1200
            20  C1x C    25.1300  -14.4200
            21  C1x C    23.9400  -15.1200
            22  C1a C    27.5800  -17.2200
BOND        25
            1     4   1 1
            2     9  10 2
            3    10  11 1
            4    11  12 2
            5    12  13 1
            6    13  14 2
            7    14   9 1
            8     8  15 1
            9     1   2 2
            10   15  16 1
            11    5   6 1
            12    6   7 1
            13    7  10 1
            14    9   8 1
            15    8   5 1
            16   16  17 1
            17   17  18 1
            18   18  19 1
            19   19  20 1
            20   20  21 1
            21   21  16 1
            22    2   3 1
            23   18  22 1
            24    3   6 2
            25    5   4 2

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