KEGG   DRUG: D08215Help
Entry
D08215                      Drug                                   

Name
Mexiletine (INN)
Formula
C11H17NO
Exact mass
179.131
Mol weight
179.2588
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiarrhythmic
Remark
Same as: 
ATC code: 
Drug group: 
Comment
Class I antiarrhythmic agent (Ib)
Target
voltage-gated sodium channel (SCN1A) blocker [HSA:6323] [KO:K04833];
voltage-gated sodium channel (SCN2A) blocker [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN3A) blocker [HSA:6328] [KO:K04836];
voltage-gated sodium channel (SCN4A) blocker [HSA:6329] [KO:K04837];
voltage-gated sodium channel (SCN5A) blocker [HSA:6331] [KO:K04838];
voltage-gated sodium channel (SCN8A) blocker [HSA:6334] [KO:K04840];
voltage-gated sodium channel (SCN9A) blocker [HSA:6335] [KO:K04841]
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
CYP inhibition: CYP1A2 [HSA:1544]
Drug interaction
Structure map
Antiarrhythmic drugs
Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BB Antiarrhythmics, class Ib
     C01BB02 Mexiletine
      D08215  Mexiletine (INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Antiarrhythmics
   Mexiletine
    D08215  Mexiletine (INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Mexiletine
      D08215  Mexiletine (INN)
    voltage-gated sodium channel (SCN2A)
     Mexiletine
      D08215  Mexiletine (INN)
    voltage-gated sodium channel (SCN3A)
     Mexiletine
      D08215  Mexiletine (INN)
    voltage-gated sodium channel (SCN4A)
     Mexiletine
      D08215  Mexiletine (INN)
    voltage-gated sodium channel (SCN5A)
     Mexiletine
      D08215  Mexiletine (INN)
    voltage-gated sodium channel (SCN8A)
     Mexiletine
      D08215  Mexiletine (INN)
    voltage-gated sodium channel (SCN9A)
     Mexiletine
      D08215  Mexiletine (INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP1A2
   Mexiletine
    D08215  Mexiletine (INN)
  CYP2D6
   Mexiletine
    D08215  Mexiletine (INN)
  CYP3A4
   Mexiletine
    D08215  Mexiletine (INN)
 Inhbitors
  CYP1A2
   Mexiletine
    D08215  Mexiletine (INN)
BRITE hierarchy
Other DBs
CAS: 
31828-71-4
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        13
            1   C8y C    22.9600  -17.9200
            2   C8y C    21.7000  -18.6200
            3   C8y C    22.9600  -16.5200
            4   O2a O    24.1500  -18.6200
            5   C8x C    20.5100  -17.9200
            6   C1a C    21.7000  -20.0200
            7   C8x C    21.7000  -15.8200
            8   C1a C    24.1500  -15.8200
            9   C1b C    25.3400  -17.9200
            10  C8x C    20.5100  -16.5200
            11  C1c C    26.6000  -18.6200
            12  C1a C    26.6000  -20.0200
            13  N1a N    27.7900  -17.9200
BOND        13
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     3   8 1
            8     4   9 1
            9     5  10 2
            10    9  11 1
            11   11  12 1
            12   11  13 1
            13    7  10 1

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