KEGG   DRUG: D08216Help
Entry
D08216                      Drug                                   

Name
Mianserin (INN);
Tolvon (TN)
Formula
C18H20N2
Exact mass
264.1626
Mol weight
264.3648
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antidepressant, tetracyclic
Remark
ATC code: 
Comment
tetracyclic antidepressants
Target
5-HT1-receptor antagonist [HSA:3350 3351 3352 3354 3355] [KO:K04153];
5-HT2-receptor antagonist [HSA:3356 3357 3358] [KO:K04157];
alpha2-adrenergic receptor antagonist [HSA:150 151 152] [KO:K04138 K04139 K04140];
alpha1-adrenergic receptor antagonist [HSA:146 147 148] [KO:K04137 K04136 K04135]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04726  Serotonergic synapse  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP1A2 [HSA:1544], CYP2C19 [HSA:1557], CYP2D6 [HSA:1565]
Interaction
Drug interaction
Structure map
Antidepressants
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AX Other antidepressants
     N06AX03 Mianserin
      D08216  Mianserin (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor [HSA:146 147 148] [KO:K04137 K04136 K04135]
     Mianserin [ATC:N06AX03]
      D08216  Mianserin (INN)
    alpha2-adrenergic receptor [HSA:150 151 152] [KO:K04138 K04139 K04140]
     Mianserin [ATC:N06AX03]
      D08216  Mianserin (INN)
   Serotonin
    5-HT1-receptor [HSA:3350 3351 3352 3354 3355] [KO:K04153]
     Mianserin [ATC:N06AX03]
      D08216  Mianserin (INN)
    5-HT2-receptor [HSA:3356 3357 3358] [KO:K04157]
     Mianserin [ATC:N06AX03]
      D08216  Mianserin (INN)
BRITE hierarchy
Other DBs
CAS: 
24219-97-4
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        20
            1   C8y C    22.2600  -23.7300
            2   N1y N    23.1700  -22.6800
            3   C1y C    24.5700  -22.6800
            4   C8y C    25.4100  -23.8000
            5   C8y C    22.5400  -25.1300
            6   C8y C    25.0600  -25.1300
            7   C1x C    23.8000  -25.7600
            8   C8x C    26.0400  -26.1100
            9   C8x C    27.4400  -25.6900
            10  C8x C    27.7200  -24.3600
            11  C8x C    26.7400  -23.3800
            12  C8x C    20.9300  -23.3100
            13  C8x C    19.8800  -24.2200
            14  C8x C    20.1600  -25.6200
            15  C8x C    21.4900  -26.0400
            16  C1x C    25.2700  -21.4900
            17  N1y N    24.5700  -20.2300
            18  C1x C    23.1700  -20.2300
            19  C1x C    22.4700  -21.4200
            20  C1a C    25.2700  -19.0400
BOND        23
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     6   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    4  11 2
            13    1  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17    5  15 2
            18    3  16 1
            19   16  17 1
            20   17  18 1
            21   18  19 1
            22    2  19 1
            23   17  20 1

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