KEGG   DRUG: D08217Help
Entry
D08217                      Drug                                   

Name
Mibefradil (INN)
Formula
C29H38FN3O3
Exact mass
495.2897
Mol weight
495.6287
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Calcium antagonist;
Vasodilator
Remark
Same as: 
ATC code: 
Drug group: 
Target
calcium channel T type blocker [HSA:8911 8912 8913] [KO:K04856 K04855 K04854]
  Pathway
hsa04010  MAPK signaling pathway
hsa04020  Calcium signaling pathway  
 
Interaction
CYP inhibition: CYP3A [HSA:1576 1577 1551], CYP1A2 [HSA:1544], CYP2D6 [HSA:1565]
Drug interaction
Structure map
Calcium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C08 CALCIUM CHANNEL BLOCKERS
   C08C SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
    C08CX Other selective calcium channel blockers with mainly vascular effects
     C08CX01 Mibefradil
      D08217  Mibefradil (INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Ca2+ channel, CACN alpha-1, CaVx.x
    calcium channel T type
     Mibefradil
      D08217  Mibefradil (INN)
Cytochrome P450 interactions [BR:br08309]
 Inhbitors
  CYP1A2
   Mibefradil
    D08217  Mibefradil (INN)
  CYP2D6
   Mibefradil
    D08217  Mibefradil (INN)
  CYP3A
   Mibefradil
    D08217  Mibefradil (INN)
BRITE hierarchy
Other DBs
CAS: 
116644-53-2
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        36
            1   C1z C    20.8600  -17.0800
            2   C1y C    19.7400  -17.7100
            3   C1x C    20.8600  -15.7500
            4   C1b C    22.1200  -17.9200
            5   O7a O    23.1700  -14.8400
            6   C8y C    18.5500  -17.0100
            7   C1c C    19.6700  -19.0400
            8   C1x C    19.8100  -15.0500
            9   C1b C    23.3100  -17.2900
            10  C7a C    24.3600  -15.5400
            11  C8y C    18.5500  -15.6800
            12  C8x C    17.4300  -17.6400
            13  C1a C    18.4800  -19.6700
            14  C1a C    20.7900  -19.8100
            15  N1c N    24.4300  -17.9900
            16  C1b C    25.5500  -14.8400
            17  O6a O    24.3600  -16.9400
            18  C8x C    17.5000  -14.9800
            19  C8x C    16.2400  -16.9400
            20  C1b C    25.6200  -17.3600
            21  C1a C    24.4300  -19.3900
            22  O2a O    26.7400  -15.5400
            23  C8y C    16.2400  -15.6100
            24  C1b C    26.7400  -18.1300
            25  C1a C    27.9300  -14.8400
            26  X   F    15.1200  -14.9100
            27  C1b C    27.9300  -17.4300
            28  C8y C    29.1200  -18.2000
            29  N4x N    29.1200  -19.5300
            30  N5x N    30.3800  -17.7100
            31  C8y C    30.5200  -19.8100
            32  C8y C    31.2200  -18.6900
            33  C8x C    31.1500  -21.0000
            34  C8x C    32.5500  -18.6900
            35  C8x C    32.4800  -21.0000
            36  C8x C    33.1800  -19.9500
BOND        39
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     1   5 1 #Up
            5     2   6 1
            6     2   7 1 #Up
            7     3   8 1
            8     4   9 1
            9     5  10 1
            10    6  11 2
            11    6  12 1
            12    7  13 1
            13    7  14 1
            14    9  15 1
            15   10  16 1
            16   10  17 2
            17   11  18 1
            18   12  19 2
            19   15  20 1
            20   15  21 1
            21   16  22 1
            22   18  23 2
            23   20  24 1
            24   22  25 1
            25   23  26 1
            26   24  27 1
            27   27  28 1
            28   28  29 1
            29   28  30 2
            30   29  31 1
            31   30  32 1
            32   31  33 1
            33   32  34 1
            34   33  35 2
            35   34  36 2
            36    8  11 1
            37   19  23 1
            38   31  32 2
            39   35  36 1

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