KEGG   DRUG: MosapramineHelp
Entry
D08235                      Drug                                   

Name
Mosapramine (INN)
Formula
C28H35ClN4O
Exact mass
478.2499
Mol weight
479.0567
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01942  Iminobenzyl antipsychotic
 DG01478  Dopamine antagonist
  DG01474  Dopamine D2-receptor antagonist
Remark
ATC code: 
Chemical group: 
Activity
Antipsychotic
Comment
Iminodibenzyl derivative
Target
HTR2A [HSA:3356] [KO:K04157];
DRD2 [HSA:1813] [KO:K04145]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
Dopaminergic synapse
Interaction
Drug interaction
Structure map
Dopamine receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AX Other antipsychotics
     N05AX10 Mosapramine
      D08235  Mosapramine (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    dopamine D2-receptor
     Mosapramine
      D08235  Mosapramine (INN)
   Serotonin
    5-HT2A-receptor
     Mosapramine
      D08235  Mosapramine (INN)
BRITE hierarchy
Other DBs
CAS: 
89419-40-9
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        34
            1   C1x C    19.2615  -19.4021
            2   C8y C    18.4911  -18.2815
            3   C8y C    18.7713  -16.9508
            4   N1y N    20.0320  -16.3905
            5   C1x C    20.6623  -19.4021
            6   C8y C    21.2926  -17.0209
            7   C8y C    21.5728  -18.3516
            8   C8x C    17.7907  -15.9703
            9   C8y C    16.4600  -16.3905
            10  C8x C    16.1098  -17.7212
            11  C8x C    17.1604  -18.7018
            12  C8x C    22.9035  -18.7718
            13  C8x C    23.9541  -17.8613
            14  C8x C    23.6739  -16.4605
            15  C8x C    22.3432  -16.0403
            16  C1b C    20.0320  -14.9897
            17  C1b C    21.2226  -14.3594
            18  C1b C    22.4132  -15.0598
            19  N1y N    23.6739  -14.4294
            20  C1x C    24.8646  -15.1298
            21  C1x C    26.1253  -14.4995
            22  C1z C    26.1253  -13.0987
            23  C1x C    24.9346  -12.3283
            24  C1x C    23.6739  -13.0287
            25  N1y N    27.1758  -14.0092
            26  C1y C    28.4365  -13.3088
            27  N1x N    28.0863  -11.9081
            28  C5x C    26.6856  -11.7680
            29  C1x C    27.1758  -15.4100
            30  C1x C    28.3665  -16.1104
            31  C1x C    29.6272  -15.4100
            32  C1x C    29.6272  -14.0092
            33  O5x O    25.9852  -10.5773
            34  X   Cl   15.4358  -15.4149
BOND        39
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    7  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17    6  15 2
            18    4  16 1
            19   16  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1
            23   20  21 1
            24   21  22 1
            25   22  23 1
            26   23  24 1
            27   19  24 1
            28   22  25 1
            29   25  26 1
            30   26  27 1
            31   27  28 1
            32   22  28 1
            33   25  29 1
            34   29  30 1
            35   30  31 1
            36   31  32 1
            37   26  32 1
            38   28  33 2
            39    9  34 1

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