KEGG   DRUG: D08235Help
Entry
D08235                      Drug                                   

Name
Mosapramine (INN)
Formula
C28H35ClN4O
Exact mass
478.2499
Mol weight
479.0567
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Neuroleptic
Remark
ATC code: 
Comment
Iminodibenzyl derivatives
Target
5-HT2A-receptor antagonist [HSA:3356] [KO:K04157];
dopamine D2-receptor antagonist [HSA:1813] [KO:K04145]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse  
 
Interaction
Drug interaction
Structure map
Dopamine receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AX Other antipsychotics
     N05AX10 Mosapramine
      D08235  Mosapramine (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    dopamine D2-receptor [HSA:1813] [KO:K04145]
     Mosapramine [ATC:N05AX10]
      D08235  Mosapramine (INN)
   Serotonin
    5-HT2A-receptor [HSA:3356] [KO:K04157]
     Mosapramine [ATC:N05AX10]
      D08235  Mosapramine (INN)
BRITE hierarchy
Other DBs
CAS: 
89419-40-9
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        34
            1   C1x C    19.2615  -19.4021
            2   C8y C    18.4911  -18.2815
            3   C8y C    18.7713  -16.9508
            4   N1y N    20.0320  -16.3905
            5   C1x C    20.6623  -19.4021
            6   C8y C    21.2926  -17.0209
            7   C8y C    21.5728  -18.3516
            8   C8x C    17.7907  -15.9703
            9   C8y C    16.4600  -16.3905
            10  C8x C    16.1098  -17.7212
            11  C8x C    17.1604  -18.7018
            12  C8x C    22.9035  -18.7718
            13  C8x C    23.9541  -17.8613
            14  C8x C    23.6739  -16.4605
            15  C8x C    22.3432  -16.0403
            16  C1b C    20.0320  -14.9897
            17  C1b C    21.2226  -14.3594
            18  C1b C    22.4132  -15.0598
            19  N1y N    23.6739  -14.4294
            20  C1x C    24.8646  -15.1298
            21  C1x C    26.1253  -14.4995
            22  C1z C    26.1253  -13.0987
            23  C1x C    24.9346  -12.3283
            24  C1x C    23.6739  -13.0287
            25  N1y N    27.1758  -14.0092
            26  C1y C    28.4365  -13.3088
            27  N1x N    28.0863  -11.9081
            28  C5x C    26.6856  -11.7680
            29  C1x C    27.1758  -15.4100
            30  C1x C    28.3665  -16.1104
            31  C1x C    29.6272  -15.4100
            32  C1x C    29.6272  -14.0092
            33  O5x O    25.9852  -10.5773
            34  X   Cl   15.4358  -15.4149
BOND        39
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    7  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17    6  15 2
            18    4  16 1
            19   16  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1
            23   20  21 1
            24   21  22 1
            25   22  23 1
            26   23  24 1
            27   19  24 1
            28   22  25 1
            29   25  26 1
            30   26  27 1
            31   27  28 1
            32   22  28 1
            33   25  29 1
            34   29  30 1
            35   30  31 1
            36   31  32 1
            37   26  32 1
            38   28  33 2
            39    9  34 1

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