KEGG   DRUG: D08242Help
Entry
D08242                      Drug                                   

Name
Nafcillin (INN)
Formula
C21H22N2O5S
Exact mass
414.1249
Mol weight
414.4748
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibiotic, penicillin, penicillinase-resistant
Remark
Same as: 
ATC code: 
Drug group: 
Comment
Semisynthetic penicillin
Target
penicillin binding proteins inhibitor
  Pathway
ko00550  Peptidoglycan biosynthesis  
 
Interaction
CYP induction: CYP1A2 [HSA:1544], CYP3A [HSA:1576 1577 1551]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01C BETA-LACTAM ANTIBACTERIALS, PENICILLINS
    J01CF Beta-lactamase resistant penicillins
     J01CF06 Nafcillin
      D08242  Nafcillin (INN)
USP drug classification [BR:br08302]
 Antibacterials
  Beta-lactam, Penicillins
   Nafcillin
    D08242  Nafcillin (INN)
Antiinfectives [BR:br08307]
 Antibacterials
  Cell wall biosynthesis inhibitor
   Penicillin binding proteins inhibitor
    Penicillins
     Nafcillin
      D08242  Nafcillin (INN)
Cytochrome P450 interactions [BR:br08309]
 Inducers
  CYP1A2
   Nafcillin
    D08242  Nafcillin (INN)
  CYP3A
   Nafcillin
    D08242  Nafcillin (INN)
BRITE hierarchy
Other DBs
CAS: 
147-52-4
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        29
            1   C1y C    25.4800  -18.2000
            2   C5x C    25.4800  -19.6000
            3   N1y N    26.8800  -19.6000
            4   C1y C    26.8800  -18.2000
            5   C1y C    28.2100  -20.0200
            6   C1z C    29.0500  -18.9000
            7   S2x S    28.2100  -17.7800
            8   C1a C    30.0300  -19.8800
            9   C1a C    30.0300  -17.9200
            10  C6a C    28.7000  -21.4200
            11  O6a O    30.1000  -21.4200
            12  O6a O    27.8600  -22.5400
            13  N1b N    24.2900  -17.5000
            14  C5a C    23.1000  -18.2000
            15  O5x O    24.2900  -20.3000
            16  O5a O    23.1000  -19.6000
            17  C8y C    21.8400  -17.5000
            18  C8y C    21.8400  -16.1000
            19  C8x C    20.6500  -15.4000
            20  C8x C    19.3900  -16.1000
            21  C8y C    19.3900  -17.5000
            22  C8y C    20.6500  -18.2000
            23  C8x C    18.2000  -18.2000
            24  C8x C    18.2000  -19.6000
            25  C8x C    19.3900  -20.3000
            26  C8x C    20.6500  -19.6000
            27  O2a O    23.0300  -15.4000
            28  C1b C    23.0300  -14.0000
            29  C1a C    24.2200  -13.3000
BOND        32
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     1   4 1
            5     3   5 1
            6     5   6 1
            7     6   7 1
            8     4   7 1
            9     6   8 1
            10    6   9 1
            11    5  10 1 #Down
            12   10  11 1
            13   10  12 2
            14    1  13 1 #Up
            15   13  14 1
            16    2  15 2
            17   14  16 2
            18   14  17 1
            19   17  18 1
            20   18  19 2
            21   19  20 1
            22   20  21 2
            23   21  22 1
            24   17  22 2
            25   21  23 1
            26   23  24 2
            27   24  25 1
            28   25  26 2
            29   22  26 1
            30   18  27 1
            31   27  28 1
            32   28  29 1

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