| Entry |
|
|---|
| Name |
Naphazoline (INN);
Nafazolin (TN) |
|---|
| Formula |
C14H14N2
|
|---|
| Exact mass |
210.1157
|
|---|
| Mol weight |
210.2744
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01456 Adrenergic receptor agonist
DG01450 alpha-Adrenergic receptor agonist
DG01448 alpha1-Adrenergic receptor agonist
|
|---|
| Remark |
| Product (DG01032): | D01021<JP> |
|
|---|
| Efficacy |
Vasoconstrictor, alpha1-Adrenergic receptor agonist |
|---|
| Comment |
Imidazoline derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04270 | Vascular smooth muscle contraction |
|
|---|
| Interaction |
|
|---|
| Structure map |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
R RESPIRATORY SYSTEM
R01 NASAL PREPARATIONS
R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
R01AA Sympathomimetics, plain
R01AA08 Naphazoline
D08253 Naphazoline (INN)
R01AB Sympathomimetics, combinations excl. corticosteroids
R01AB02 Naphazoline
D08253 Naphazoline (INN)
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01G DECONGESTANTS AND ANTIALLERGICS
S01GA Sympathomimetics used as decongestants
S01GA01 Naphazoline
D08253 Naphazoline (INN)
Risk category of Japanese OTC drugs [BR:br08312]
Second-class OTC drugs
Inorganic and organic chemicals
Naphazoline
D08253 Naphazoline (INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01456 Adrenergic receptor agonist
DG01450 alpha-Adrenergic receptor agonist
DG01448 alpha1-Adrenergic receptor agonist
DG01032 Naphazoline
D08253 Naphazoline
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRA1
D08253 Naphazoline (INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01456 Adrenergic receptor agonist
DG01450 alpha-Adrenergic receptor agonist
DG01448 alpha1-Adrenergic receptor agonist
DG01032 Naphazoline
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 16
1 C8y C 23.0300 -19.1800
2 C8y C 24.2200 -18.4800
3 C8y C 23.0300 -20.5800
4 C8x C 21.9100 -18.4800
5 C1b C 24.2200 -17.0800
6 C8x C 25.5500 -19.1800
7 C8x C 24.2200 -21.2800
8 C8x C 21.9100 -21.2800
9 C8x C 20.6500 -19.1800
10 C2y C 25.4800 -16.4500
11 C8x C 25.5500 -20.5800
12 C8x C 20.6500 -20.5800
13 N1x N 26.8100 -16.9400
14 N2x N 25.4800 -15.1200
15 C1x C 27.6500 -15.7500
16 C1x C 26.8100 -14.6300
BOND 18
1 1 2 1
2 1 3 2
3 1 4 1
4 2 5 1
5 2 6 2
6 3 7 1
7 3 8 1
8 4 9 2
9 5 10 1
10 6 11 1
11 8 12 2
12 10 13 1
13 10 14 2
14 13 15 1
15 14 16 1
16 7 11 2
17 9 12 1
18 15 16 1
|
|---|
