KEGG   DRUG: NaphazolineHelp
Entry
D08253                      Drug                                   

Name
Naphazoline (INN);
Nafazolin (TN)
Formula
C14H14N2
Exact mass
210.1157
Mol weight
210.2744
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01456  Adrenergic receptor agonist
  DG01450  alpha-Adrenergic receptor agonist
   DG01448  alpha1-Adrenergic receptor agonist
    DG01654  alpha1-Adrenergic receptor specific agonist
Remark
ATC code: 
Chemical group: 
Activity
Vasoconstrictor, alpha1-Adrenergic receptor agonist
Comment
Imidazoline derivative
Target
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Salivary secretion
Interaction
Drug interaction
Structure map
Naphthalene family
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AA Sympathomimetics, plain
     R01AA08 Naphazoline
      D08253  Naphazoline (INN)
    R01AB Sympathomimetics, combinations excl. corticosteroids
     R01AB02 Naphazoline
      D08253  Naphazoline (INN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01G DECONGESTANTS AND ANTIALLERGICS
    S01GA Sympathomimetics used as decongestants
     S01GA01 Naphazoline
      D08253  Naphazoline (INN)
USP drug classification [BR:br08302]
 Ophthalmic Agents
  Ophthalmic Agents, Other
   Naphazoline
    D08253  Naphazoline (INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Naphazoline
    D08253  Naphazoline (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor
     Naphazoline
      D08253  Naphazoline (INN)
BRITE hierarchy
Other DBs
CAS: 
835-31-4
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        16
            1   C8y C    23.0300  -19.1800
            2   C8y C    24.2200  -18.4800
            3   C8y C    23.0300  -20.5800
            4   C8x C    21.9100  -18.4800
            5   C1b C    24.2200  -17.0800
            6   C8x C    25.5500  -19.1800
            7   C8x C    24.2200  -21.2800
            8   C8x C    21.9100  -21.2800
            9   C8x C    20.6500  -19.1800
            10  C2y C    25.4800  -16.4500
            11  C8x C    25.5500  -20.5800
            12  C8x C    20.6500  -20.5800
            13  N1x N    26.8100  -16.9400
            14  N2x N    25.4800  -15.1200
            15  C1x C    27.6500  -15.7500
            16  C1x C    26.8100  -14.6300
BOND        18
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     3   8 1
            8     4   9 2
            9     5  10 1
            10    6  11 1
            11    8  12 2
            12   10  13 1
            13   10  14 2
            14   13  15 1
            15   14  16 1
            16    7  11 2
            17    9  12 1
            18   15  16 1

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