KEGG   DRUG: D08253Help
Entry
D08253                      Drug                                   

Name
Naphazoline (INN);
Nafazolin (TN)
Formula
C14H14N2
Exact mass
210.1157
Mol weight
210.2744
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Vasoconstrictor ORL, local
Remark
ATC code: 
Drug group: 
Target
alpha1-adrenergic receptor agonist [HSA:146 147 148] [KO:K04137 K04136 K04135]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04970  Salivary secretion  
 
Structure map
Naphthalene family
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AA Sympathomimetics, plain
     R01AA08 Naphazoline
      D08253  Naphazoline (INN)
    R01AB Sympathomimetics, combinations excl. corticosteroids
     R01AB02 Naphazoline
      D08253  Naphazoline (INN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01G DECONGESTANTS AND ANTIALLERGICS
    S01GA Sympathomimetics used as decongestants
     S01GA01 Naphazoline
      D08253  Naphazoline (INN)
USP drug classification [BR:br08302]
 Ophthalmic Agents
  Ophthalmic Agents, Other
   Naphazoline
    D08253  Naphazoline (INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Naphazoline
    D08253  Naphazoline (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor
     Naphazoline
      D08253  Naphazoline (INN)
BRITE hierarchy
Other DBs
CAS: 
835-31-4
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        16
            1   C8y C    23.0300  -19.1800
            2   C8y C    24.2200  -18.4800
            3   C8y C    23.0300  -20.5800
            4   C8x C    21.9100  -18.4800
            5   C1b C    24.2200  -17.0800
            6   C8x C    25.5500  -19.1800
            7   C8x C    24.2200  -21.2800
            8   C8x C    21.9100  -21.2800
            9   C8x C    20.6500  -19.1800
            10  C2y C    25.4800  -16.4500
            11  C8x C    25.5500  -20.5800
            12  C8x C    20.6500  -20.5800
            13  N1x N    26.8100  -16.9400
            14  N2x N    25.4800  -15.1200
            15  C1x C    27.6500  -15.7500
            16  C1x C    26.8100  -14.6300
BOND        18
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     3   8 1
            8     4   9 2
            9     5  10 1
            10    6  11 1
            11    8  12 2
            12   10  13 1
            13   10  14 2
            14   13  15 1
            15   14  16 1
            16    7  11 2
            17    9  12 1
            18   15  16 1

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