KEGG   DRUG: D08255Help
Entry
D08255                      Drug                                   

Name
Naratriptan (INN);
Naramig (TN)
Formula
C17H25N3O2S
Exact mass
335.1667
Mol weight
335.4643
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antimigraine;
Serotonin agonist
Remark
Same as: 
ATC code: 
Drug group: 
Target
5-HT1A-receptor agonist [HSA:3350] [KO:K04153];
5-HT1B-receptor agonist [HSA:3351] [KO:K04153];
5-HT1D-receptor agonist [HSA:3352] [KO:K04153];
5-HT1E-receptor agonist [HSA:3354] [KO:K04153];
5-HT1F-receptor agonist [HSA:3355] [KO:K04153]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse  
 
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP2C9 [HSA:1559], CYP2D6 [HSA:1565], CYP2E1 [HSA:1571], CYP3A4 [HSA:1576], CYP3A5 [HSA:1577]
Interaction
Drug interaction
Structure map
Antimigraines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02C ANTIMIGRAINE PREPARATIONS
    N02CC Selective serotonin (5HT1) agonists
     N02CC02 Naratriptan
      D08255  Naratriptan (INN)
USP drug classification [BR:br08302]
 Antimigraine Agents
  Serotonin (5-HT) 1b/1d Receptor Agonists
   Naratriptan
    D08255  Naratriptan (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Serotonin
    5-HT1A-receptor
     Naratriptan
      D08255  Naratriptan (INN)
    5-HT1B-receptor
     Naratriptan
      D08255  Naratriptan (INN)
    5-HT1D-receptor
     Naratriptan
      D08255  Naratriptan (INN)
    5-HT1E-receptor
     Naratriptan
      D08255  Naratriptan (INN)
    5-HT1F-receptor
     Naratriptan
      D08255  Naratriptan (INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP1A2
   Naratriptan
    D08255  Naratriptan (INN)
  CYP2C9
   Naratriptan
    D08255  Naratriptan (INN)
  CYP2D6
   Naratriptan
    D08255  Naratriptan (INN)
  CYP3A4
   Naratriptan
    D08255  Naratriptan (INN)
  CYP3A5
   Naratriptan
    D08255  Naratriptan (INN)
BRITE hierarchy
Other DBs
CAS: 
121679-13-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        23
            1   C8y C    27.1600  -19.9500
            2   C8y C    28.4900  -19.4600
            3   C8y C    27.1600  -21.3500
            4   C8x C    25.9000  -19.2500
            5   C8x C    29.3300  -20.6500
            6   N4x N    28.4900  -21.7700
            7   C8x C    25.9000  -22.0500
            8   C8y C    24.7100  -19.9500
            9   C8x C    24.7100  -21.3500
            10  C1b C    23.5200  -19.2500
            11  C1b C    22.3300  -19.9500
            12  S4a S    21.0700  -19.2500
            13  N1b N    19.8800  -19.9500
            14  O3c O    22.3300  -18.5500
            15  O3c O    19.8800  -18.5500
            16  C1a C    18.6900  -19.2500
            17  C1y C    28.4900  -18.0600
            18  C1x C    29.6800  -17.3600
            19  C1x C    29.6800  -15.9600
            20  N1y N    28.4900  -15.2600
            21  C1x C    27.3000  -15.9600
            22  C1x C    27.3000  -17.3600
            23  C1a C    28.4900  -13.8600
BOND        25
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     3   6 1
            6     3   7 1
            7     4   8 2
            8     7   9 2
            9     8  10 1
            10   10  11 1
            11   11  12 1
            12   12  13 1
            13   12  14 2
            14   12  15 2
            15   13  16 1
            16    5   6 1
            17    8   9 1
            18    2  17 1
            19   17  18 1
            20   18  19 1
            21   19  20 1
            22   20  21 1
            23   21  22 1
            24   17  22 1
            25   20  23 1

» Japanese version   » Back

DBGET integrated database retrieval system