KEGG   DRUG: D08255Help
Entry
D08255                      Drug                                   

Name
Naratriptan (INN);
Naramig (TN)
Formula
C17H25N3O2S
Exact mass
335.1667
Mol weight
335.4643
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antimigraine;
Serotonin agonist
Remark
Same as: 
ATC code: 
Target
5-HT1A-receptor agonist [HSA:3350] [KO:K04153];
5-HT1B-receptor agonist [HSA:3351] [KO:K04153];
5-HT1D-receptor agonist [HSA:3352] [KO:K04153];
5-HT1E-receptor agonist [HSA:3354] [KO:K04153];
5-HT1F-receptor agonist [HSA:3355] [KO:K04153]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse  
 
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP2C9 [HSA:1559], CYP2D6 [HSA:1565], CYP2E1 [HSA:1571], CYP3A4 [HSA:1576], CYP3A5 [HSA:1577]
Interaction
Drug interaction
Structure map
Antimigraines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02C ANTIMIGRAINE PREPARATIONS
    N02CC Selective serotonin (5HT1) agonists
     N02CC02 Naratriptan
      D08255  Naratriptan (INN)
USP drug classification [BR:br08302]
 Antimigraine Agents
  Serotonin (5-HT) 1b/1d Receptor Agonists
   Naratriptan
    D08255  Naratriptan (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Serotonin
    5-HT1B-receptor [HSA:3351] [KO:K04153]
     Naratriptan [ATC:N02CC02]
      D08255  Naratriptan (INN)
    5-HT1D-receptor [HSA:3352] [KO:K04153]
     Naratriptan [ATC:N02CC02]
      D08255  Naratriptan (INN)
BRITE hierarchy
Other DBs
CAS: 
121679-13-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        23
            1   C8y C    27.1600  -19.9500
            2   C8y C    28.4900  -19.4600
            3   C8y C    27.1600  -21.3500
            4   C8x C    25.9000  -19.2500
            5   C8x C    29.3300  -20.6500
            6   N4x N    28.4900  -21.7700
            7   C8x C    25.9000  -22.0500
            8   C8y C    24.7100  -19.9500
            9   C8x C    24.7100  -21.3500
            10  C1b C    23.5200  -19.2500
            11  C1b C    22.3300  -19.9500
            12  S4a S    21.0700  -19.2500
            13  N1b N    19.8800  -19.9500
            14  O3c O    22.3300  -18.5500
            15  O3c O    19.8800  -18.5500
            16  C1a C    18.6900  -19.2500
            17  C1y C    28.4900  -18.0600
            18  C1x C    29.6800  -17.3600
            19  C1x C    29.6800  -15.9600
            20  N1y N    28.4900  -15.2600
            21  C1x C    27.3000  -15.9600
            22  C1x C    27.3000  -17.3600
            23  C1a C    28.4900  -13.8600
BOND        25
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     3   6 1
            6     3   7 1
            7     4   8 2
            8     7   9 2
            9     8  10 1
            10   10  11 1
            11   11  12 1
            12   12  13 1
            13   12  14 2
            14   12  15 2
            15   13  16 1
            16    5   6 1
            17    8   9 1
            18    2  17 1
            19   17  18 1
            20   18  19 1
            21   19  20 1
            22   20  21 1
            23   21  22 1
            24   17  22 1
            25   20  23 1

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