KEGG   DRUG: D08270Help
Entry
D08270                      Drug                                   

Name
Nicardipine (INN);
Cardene (TN)
Formula
C26H29N3O6
Exact mass
479.2056
Mol weight
479.525
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Vasodilator, cerebral
Remark
Same as: 
ATC code: 
Drug group: 
Comment
dihydropyridine calcium channel blocker
Indication: Hypertension
Target
calcium channel L type blocker [HSA:775 776 778 779] [KO:K04850 K04851 K04853 K04857]
  Pathway
hsa04010  MAPK signaling pathway
hsa04020  Calcium signaling pathway
hsa04260  Cardiac muscle contraction
hsa04270  Vascular smooth muscle contraction  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Calcium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C08 CALCIUM CHANNEL BLOCKERS
   C08C SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
    C08CA Dihydropyridine derivatives
     C08CA04 Nicardipine
      D08270  Nicardipine (INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Calcium Channel Blocking Agents
   Nicardipine
    D08270  Nicardipine (INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Ca2+ channel, CACN alpha-1, CaVx.x
    calcium channel L type
     Nicardipine
      D08270  Nicardipine (INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP3A4
   Nicardipine
    D08270  Nicardipine (INN)
BRITE hierarchy
Other DBs
CAS: 
55985-32-5
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        35
            1   C1y C    20.5800  -16.3800
            2   C8y C    20.5800  -17.7800
            3   C2y C    21.7700  -15.6800
            4   C2y C    19.3900  -15.6800
            5   C8x C    21.8400  -18.4800
            6   C8x C    19.3900  -18.4800
            7   C2y C    21.7700  -14.3500
            8   C7a C    23.0300  -16.3800
            9   C2y C    19.3900  -14.3500
            10  C7a C    18.2000  -16.3800
            11  C8y C    21.8400  -19.8100
            12  C8x C    19.3900  -19.8800
            13  N1x N    20.5800  -13.6500
            14  C1a C    23.0300  -13.6500
            15  O7a O    24.2200  -15.6800
            16  O6a O    23.0300  -17.7800
            17  C1a C    18.2000  -13.6500
            18  O7a O    17.0100  -15.6800
            19  O6a O    18.2000  -17.7800
            20  C8x C    20.6500  -20.5100
            21  N2b N    23.0300  -20.5100 #+
            22  C1b C    25.4100  -16.3800
            23  C1a C    15.8200  -16.3800
            24  O3a O    24.5000  -19.6000
            25  O3a O    23.0300  -22.2600 #-
            26  C1b C    26.6000  -15.6800
            27  N1c N    27.7900  -16.3800
            28  C1b C    28.9800  -15.6800
            29  C1a C    27.7900  -17.7800
            30  C8y C    30.1700  -16.3800
            31  C8x C    30.1700  -17.7800
            32  C8x C    31.3600  -15.6800
            33  C8x C    31.3600  -18.4800
            34  C8x C    32.5500  -16.3800
            35  C8x C    32.5500  -17.7800
BOND        37
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 2
            7     3   8 1
            8     4   9 2
            9     4  10 1
            10    5  11 2
            11    6  12 1
            12    7  13 1
            13    7  14 1
            14    8  15 1
            15    8  16 2
            16    9  17 1
            17   10  18 1
            18   10  19 2
            19   11  20 1
            20   11  21 1
            21   15  22 1
            22   18  23 1
            23   21  24 2
            24   21  25 1
            25   22  26 1
            26   26  27 1
            27   27  28 1
            28   27  29 1
            29   28  30 1
            30   30  31 2
            31   30  32 1
            32   31  33 1
            33   32  34 2
            34   33  35 2
            35    9  13 1
            36   12  20 2
            37   34  35 1

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