KEGG   DRUG: NicardipineHelp
Entry
D08270                      Drug                                   

Name
Nicardipine (INN);
Cardene (TN)
Formula
C26H29N3O6
Exact mass
479.2056
Mol weight
479.525
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01928  Dihydropyridine calcium channel blocker
Other
 DG01575  Calcium channel blocker
  DG01496  Calcium channel L type blocker
Cyp substrate
 DG01633  CYP3A4 substrate
Remark
Same as: 
ATC code: 
Chemical group: 
Activity
Antihypertensive, Vasodilator, Calcium channel blocker
Comment
Dihydropyridine derivative
Indication: Hypertension
Target
CACNA1-L [HSA:775 776 778 779] [KO:K04850 K04851 K04853 K04857]
  Pathway
MAPK signaling pathway
Calcium signaling pathway
Cardiac muscle contraction
Vascular smooth muscle contraction
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Calcium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C08 CALCIUM CHANNEL BLOCKERS
   C08C SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
    C08CA Dihydropyridine derivatives
     C08CA04 Nicardipine
      D08270  Nicardipine (INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Calcium Channel Blocking Agents
   Nicardipine
    D08270  Nicardipine (INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Ca2+ channel, CACN alpha-1, CaVx.x
    calcium channel L type
     Nicardipine
      D08270  Nicardipine (INN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP3A4
   Nicardipine
    D08270  Nicardipine (INN)
BRITE hierarchy
Other DBs
CAS: 
55985-32-5
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        35
            1   C1y C    20.5800  -16.3800
            2   C8y C    20.5800  -17.7800
            3   C2y C    21.7700  -15.6800
            4   C2y C    19.3900  -15.6800
            5   C8x C    21.8400  -18.4800
            6   C8x C    19.3900  -18.4800
            7   C2y C    21.7700  -14.3500
            8   C7a C    23.0300  -16.3800
            9   C2y C    19.3900  -14.3500
            10  C7a C    18.2000  -16.3800
            11  C8y C    21.8400  -19.8100
            12  C8x C    19.3900  -19.8800
            13  N1x N    20.5800  -13.6500
            14  C1a C    23.0300  -13.6500
            15  O7a O    24.2200  -15.6800
            16  O6a O    23.0300  -17.7800
            17  C1a C    18.2000  -13.6500
            18  O7a O    17.0100  -15.6800
            19  O6a O    18.2000  -17.7800
            20  C8x C    20.6500  -20.5100
            21  N2b N    23.0300  -20.5100 #+
            22  C1b C    25.4100  -16.3800
            23  C1a C    15.8200  -16.3800
            24  O3a O    24.5000  -19.6000
            25  O3a O    23.0300  -22.2600 #-
            26  C1b C    26.6000  -15.6800
            27  N1c N    27.7900  -16.3800
            28  C1b C    28.9800  -15.6800
            29  C1a C    27.7900  -17.7800
            30  C8y C    30.1700  -16.3800
            31  C8x C    30.1700  -17.7800
            32  C8x C    31.3600  -15.6800
            33  C8x C    31.3600  -18.4800
            34  C8x C    32.5500  -16.3800
            35  C8x C    32.5500  -17.7800
BOND        37
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 2
            7     3   8 1
            8     4   9 2
            9     4  10 1
            10    5  11 2
            11    6  12 1
            12    7  13 1
            13    7  14 1
            14    8  15 1
            15    8  16 2
            16    9  17 1
            17   10  18 1
            18   10  19 2
            19   11  20 1
            20   11  21 1
            21   15  22 1
            22   18  23 1
            23   21  24 2
            24   21  25 1
            25   22  26 1
            26   26  27 1
            27   27  28 1
            28   27  29 1
            29   28  30 1
            30   30  31 2
            31   30  32 1
            32   31  33 1
            33   32  34 2
            34   33  35 2
            35    9  13 1
            36   12  20 2
            37   34  35 1

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