| Entry |
|
|---|
| Name |
Norepinephrine hydrochoride;
(-)-Noradrenaline hydrochloride;
Arterenol (TN) |
|---|
| Formula |
C8H11NO3. HCl
|
|---|
| Exact mass |
205.0506
|
|---|
| Mol weight |
205.6388
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01703 Cardiotonic
DG01699 Catecholamine cardiotonic
DG01456 Adrenergic receptor agonist
DG01951 Catecholamine adrenergic receptor agonist
Metabolizing enzyme substrate
DG01592 COMT substrate
DG02917 MAO substrate
|
|---|
| Remark |
| Product (DG00212): | D00076<JP> D05206<US> |
|
|---|
| Efficacy |
Antihypotensive, Vasoconstrictor, Adrenergic receptor agonist |
|---|
| Comment |
Catecholamine derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
| hsa04270 | Vascular smooth muscle contraction |
|
|---|
| Metabolism |
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C01 CARDIAC THERAPY
C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
C01CA Adrenergic and dopaminergic agents
C01CA03 Norepinephrine
D08284 Norepinephrine hydrochoride
Drug groups [BR:br08330]
Cardiovascular agent
DG01703 Cardiotonic
DG01699 Catecholamine cardiotonic
DG00212 Norepinephrine
D08284 Norepinephrine hydrochoride
DG01456 Adrenergic receptor agonist
DG00212 Norepinephrine
D08284 Norepinephrine hydrochoride
DG01951 Catecholamine adrenergic receptor agonist
DG00212 Norepinephrine
D08284 Norepinephrine hydrochoride
Metabolizing enzyme substrate
DG01592 COMT substrate
DG00212 Norepinephrine
D08284 Norepinephrine hydrochoride
DG02917 MAO substrate
DG00212 Norepinephrine
D08284 Norepinephrine hydrochoride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRA1
D08284 Norepinephrine hydrochoride
ADRA2
D08284 Norepinephrine hydrochoride
ADRB
D08284 Norepinephrine hydrochoride
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D08284
Drug groups [BR:br08330]
Cardiovascular agent
DG01703 Cardiotonic
DG01699 Catecholamine cardiotonic
DG00212 Norepinephrine
DG01456 Adrenergic receptor agonist
DG00212 Norepinephrine
DG01951 Catecholamine adrenergic receptor agonist
DG00212 Norepinephrine
Metabolizing enzyme substrate
DG01592 COMT substrate
DG00212 Norepinephrine
DG02917 MAO substrate
DG00212 Norepinephrine
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 13
1 C8y C 24.2200 -17.9200
2 C8x C 24.2200 -19.3200
3 C8x C 22.9600 -17.2200
4 C1c C 25.4100 -17.2200
5 C8x C 22.9600 -20.0200
6 C8y C 21.7700 -17.9200
7 C1b C 26.6000 -17.9200
8 O1a O 25.4100 -15.8200
9 C8y C 21.7700 -19.3200
10 N1a N 27.7900 -17.2200
11 O1a O 20.5800 -20.0200
12 O1a O 20.5800 -17.2200
13 X Cl 30.3100 -19.5300
BOND 12
1 1 2 2
2 1 3 1
3 1 4 1
4 2 5 1
5 3 6 2
6 4 7 1
7 4 8 1 #Up
8 5 9 2
9 7 10 1
10 9 11 1
11 6 9 1
12 6 12 1
|
|---|
