KEGG   DRUG: D08284Help
Entry
D08284                      Drug                                   
Name
Norepinephrine hydrochoride;
(-)-Noradrenaline hydrochloride;
Arterenol (TN)
Formula
C8H11NO3. HCl
Exact mass
205.0506
Mol weight
205.6388
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
alpha-Sympathomimetic
Remark
ATC code: 
Target
alpha1-adrenergic receptor agonist [HSA:146 147 148] [KO:K04137 K04136 K04135];
alpha2-adrenergic receptor agonist [HSA:150 151 152] [KO:K04138 K04139 K04140];
beta1-adrenergic receptor agonist [HSA:153] [KO:K04141];
beta2-adrenergic receptor agonist [HSA:154] [KO:K04142];
beta3-adrenergic receptor agonist [HSA:155] [KO:K04143]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04970  Salivary secretion  
 
Metabolism
Enzyme: MAOA [HSA:4128]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
    C01CA Adrenergic and dopaminergic agents
     C01CA03 Norepinephrine
      D08284  Norepinephrine hydrochoride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor [HSA:146 147 148] [KO:K04137 K04136 K04135]
     Norepinephrine [ATC:C01CA03]
      D08284  Norepinephrine hydrochoride
    alpha2-adrenergic receptor [HSA:150 151 152] [KO:K04138 K04139 K04140]
     Norepinephrine [ATC:C01CA03]
      D08284  Norepinephrine hydrochoride
    beta1-adrenergic receptor [HSA:153] [KO:K04141]
     Norepinephrine [ATC:C01CA03]
      D08284  Norepinephrine hydrochoride
    beta2-adrenergic receptor [HSA:154] [KO:K04142]
     Norepinephrine [ATC:C01CA03]
      D08284  Norepinephrine hydrochoride
    beta3-adrenergic receptor [HSA:155] [KO:K04143]
     Norepinephrine [ATC:C01CA03]
      D08284  Norepinephrine hydrochoride
BRITE hierarchy
Other DBs
CAS: 
329-56-6
PubChem: 
LigandBox: 
KCF data Show

ATOM        13
            1   C8y C    24.2200  -17.9200
            2   C8x C    24.2200  -19.3200
            3   C8x C    22.9600  -17.2200
            4   C1c C    25.4100  -17.2200
            5   C8x C    22.9600  -20.0200
            6   C8y C    21.7700  -17.9200
            7   C1b C    26.6000  -17.9200
            8   O1a O    25.4100  -15.8200
            9   C8y C    21.7700  -19.3200
            10  N1a N    27.7900  -17.2200
            11  O1a O    20.5800  -20.0200
            12  O1a O    20.5800  -17.2200
            13  X   Cl   30.3100  -19.5300
BOND        12
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 2
            6     4   7 1
            7     4   8 1 #Up
            8     5   9 2
            9     7  10 1
            10    9  11 1
            11    6   9 1
            12    6  12 1

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