KEGG   DRUG: Norfloxacin nicotinateHelp
Entry
D08287                      Drug                                   

Name
Norfloxacin nicotinate;
Quinabic soluble powder (TN) [veterinary]
Formula
C16H18FN3O3. C6H5NO2
Exact mass
442.1652
Mol weight
442.4402
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antibacterial
 DG01550  Quinolone
  DG01549  Fluoroquinolone
Other
 DG01529  Topoisomerase inhibitor
  DG01528  Topoisomerase IV inhibitor
Cyp substrate
 DG01892  CYP1A2 substrate
Cyp inhibitor
 DG01634  CYP1A2 inhibitor
 DG01522  CYP3A4 inhibitor
 DG01915  CYP3A5 inhibitor
Remark
ATC code: 
Chemical group: 
Activity
Antibacterial, Nucleic acid biosynthesis inhibitor
Comment
Fluoroquiolones
Target
DNA gyrase [KO:K02469 K02470];
topoisomerase IV [KO:K02621 K02622]
Metabolism
Enzyme: CYP1A2 [HSA:1544]
Interaction
CYP inhibition: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551], CYP1A2 [HSA:1544]
Drug interaction
Structure map
Quinolones
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01M QUINOLONE ANTIBACTERIALS
    J01MA Fluoroquinolones
     J01MA06 Norfloxacin
      D08287  Norfloxacin nicotinate
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AE Fluoroquinolones
     S01AE02 Norfloxacin
      D08287  Norfloxacin nicotinate
USP drug classification [BR:br08302]
 Antibacterials
  Quinolones
   Norfloxacin
    D08287  Norfloxacin nicotinate
Antiinfectives [BR:br08307]
 Antibacterials
  Nucleic acid synthesis inhibitor
   type II topoisomerase (DNA gyrase, topoisomerase IV) inhibitor
    Fluoroquinolones
     Norfloxacin
      D08287  Norfloxacin nicotinate
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP1A2
   Norfloxacin
    D08287  Norfloxacin nicotinate
 CYP substrates
  CYP1A2
   Norfloxacin
    D08287  Norfloxacin nicotinate
Phytochemicals used as drugs [BR:br08306]
 Alkaloids
  Alkaloids derived from nicotinic acid
   Pyridine alkaloids
    D08287  Norfloxacin nicotinate
BRITE hierarchy
Other DBs
CAS: 
118803-81-9
PubChem: 
LigandBox: 
KCF data Show

ATOM        32
            1   C8y C    24.7100  -18.2700
            2   C8y C    24.7100  -16.8700
            3   N4y N    25.9700  -18.9700
            4   C8x C    23.5200  -18.9700
            5   C8y C    25.9700  -16.1700
            6   C8x C    23.5200  -16.1700
            7   C8x C    27.1600  -18.2700
            8   C1b C    25.9700  -20.3700
            9   C8y C    22.2600  -18.2700
            10  C8y C    27.1600  -16.8700
            11  O5x O    25.9700  -14.7700
            12  C8y C    22.2600  -16.8700
            13  C1a C    24.7100  -21.0700
            14  N1y N    21.0700  -18.9700
            15  C6a C    28.4200  -16.1700
            16  X   F    21.0700  -16.2400
            17  C1x C    19.8800  -18.2700
            18  C1x C    21.0700  -20.3700
            19  O6a O    29.6100  -16.8700
            20  O6a O    28.4200  -14.7700
            21  C1x C    18.6900  -18.9700
            22  C1x C    19.8800  -21.0700
            23  N1x N    18.6900  -20.3700
            24  C8x C    32.6200  -17.2900
            25  C8x C    32.6200  -18.6900
            26  N5x N    33.8324  -19.3900
            27  C8x C    35.0449  -18.6900
            28  C8y C    35.0449  -17.2900
            29  C8x C    33.8324  -16.5900
            30  C6a C    36.2760  -16.5790
            31  O6a O    37.4812  -17.2747
            32  O6a O    36.2757  -15.1901
BOND        34
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 2
            9     5  10 1
            10    5  11 2
            11    6  12 2
            12    8  13 1
            13    9  14 1
            14   10  15 1
            15   12  16 1
            16   14  17 1
            17   14  18 1
            18   15  19 1
            19   15  20 2
            20   17  21 1
            21   18  22 1
            22   21  23 1
            23    7  10 2
            24    9  12 1
            25   22  23 1
            26   24  25 2
            27   25  26 1
            28   26  27 2
            29   27  28 1
            30   28  29 2
            31   24  29 1
            32   28  30 1
            33   30  31 1
            34   30  32 2

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