KEGG   DRUG: D08287Help
Entry
D08287                      Drug                                   

Name
Norfloxacin nicotinate;
Quinabic soluble powder (TN) [veterinary]
Formula
C16H18FN3O3. C6H5NO2
Exact mass
442.1652
Mol weight
442.4402
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibiotic, gyrace inhibitor
Remark
ATC code: 
Drug group: 
Target
DNA gyrase inhibitor [KO:K02469 K02470];
topoisomerase IV inhibitor [KO:K02621 K02622]
Metabolism
Enzyme: CYP1A2 [HSA:1544]
Interaction
CYP inhibition: CYP1A2 [HSA:1544]
Drug interaction
Structure map
Quinolones
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01M QUINOLONE ANTIBACTERIALS
    J01MA Fluoroquinolones
     J01MA06 Norfloxacin
      D08287  Norfloxacin nicotinate
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AE Fluoroquinolones
     S01AE02 Norfloxacin
      D08287  Norfloxacin nicotinate
USP drug classification [BR:br08302]
 Antibacterials
  Quinolones
   Norfloxacin
    D08287  Norfloxacin nicotinate
Antiinfectives [BR:br08307]
 Antibacterials
  Nucleic acid synthesis inhibitor
   type II topoisomerase (DNA gyrase, topoisomerase IV) inhibitor
    Fluoroquinolones
     Norfloxacin
      D08287  Norfloxacin nicotinate
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP1A2
   Norfloxacin
    D08287  Norfloxacin nicotinate
 Inhbitors
  CYP1A2
   Norfloxacin
    D08287  Norfloxacin nicotinate
Phytochemicals used as drugs [BR:br08306]
 Alkaloids
  Alkaloids derived from nicotinic acid
   Pyridine alkaloids
    D08287  Norfloxacin nicotinate
BRITE hierarchy
Other DBs
CAS: 
118803-81-9
PubChem: 
LigandBox: 
KCF data Show

ATOM        32
            1   C8y C    24.7100  -18.2700
            2   C8y C    24.7100  -16.8700
            3   N4y N    25.9700  -18.9700
            4   C8x C    23.5200  -18.9700
            5   C8y C    25.9700  -16.1700
            6   C8x C    23.5200  -16.1700
            7   C8x C    27.1600  -18.2700
            8   C1b C    25.9700  -20.3700
            9   C8y C    22.2600  -18.2700
            10  C8y C    27.1600  -16.8700
            11  O5x O    25.9700  -14.7700
            12  C8y C    22.2600  -16.8700
            13  C1a C    24.7100  -21.0700
            14  N1y N    21.0700  -18.9700
            15  C6a C    28.4200  -16.1700
            16  X   F    21.0700  -16.2400
            17  C1x C    19.8800  -18.2700
            18  C1x C    21.0700  -20.3700
            19  O6a O    29.6100  -16.8700
            20  O6a O    28.4200  -14.7700
            21  C1x C    18.6900  -18.9700
            22  C1x C    19.8800  -21.0700
            23  N1x N    18.6900  -20.3700
            24  C8x C    32.6200  -17.2900
            25  C8x C    32.6200  -18.6900
            26  N5x N    33.8324  -19.3900
            27  C8x C    35.0449  -18.6900
            28  C8y C    35.0449  -17.2900
            29  C8x C    33.8324  -16.5900
            30  C6a C    36.2760  -16.5790
            31  O6a O    37.4812  -17.2747
            32  O6a O    36.2757  -15.1901
BOND        34
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 2
            9     5  10 1
            10    5  11 2
            11    6  12 2
            12    8  13 1
            13    9  14 1
            14   10  15 1
            15   12  16 1
            16   14  17 1
            17   14  18 1
            18   15  19 1
            19   15  20 2
            20   17  21 1
            21   18  22 1
            22   21  23 1
            23    7  10 2
            24    9  12 1
            25   22  23 1
            26   24  25 2
            27   25  26 1
            28   26  27 2
            29   27  28 1
            30   28  29 2
            31   24  29 1
            32   28  30 1
            33   30  31 1
            34   30  32 2

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