KEGG   DRUG: D08288Help
Entry
D08288                      Drug                                   

Name
Nortriptyline (INN);
Nortrilen (TN)
Formula
C19H21N
Exact mass
263.1674
Mol weight
263.3767
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antidepressant, tricyclic
Remark
Same as: 
ATC code: 
Comment
Tricyclic antidepressants
Target
serotonin transporter inhibitor [HSA:6532] [KO:K05037];
noradrenalin transporter inhibitor [HSA:6530] [KO:K05035]
  Pathway
hsa04726  Serotonergic synapse  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Antidepressants
Antimigraines
Neurotransmitter transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AA Non-selective monoamine reuptake inhibitors
     N06AA10 Nortriptyline
      D08288  Nortriptyline (INN)
USP drug classification [BR:br08302]
 Antidepressants
  Tricyclics
   Nortriptyline
    D08288  Nortriptyline (INN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (noradrenalin transporter) [HSA:6530] [KO:K05035]
     Nortriptyline [ATC:N06AA10]
      D08288  Nortriptyline (INN)
    SLC6A4 (serotonin transporter) [HSA:6532] [KO:K05037]
     Nortriptyline [ATC:N06AA10]
      D08288  Nortriptyline (INN)
BRITE hierarchy
Other DBs
CAS: 
72-69-5
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        20
            1   C1x C    22.9600  -20.5100
            2   C8y C    22.0500  -19.3900
            3   C8y C    22.4000  -17.9900
            4   C2y C    23.6600  -17.4300
            5   C1x C    24.4300  -20.5100
            6   C8y C    24.9900  -18.0600
            7   C8y C    25.2700  -19.3900
            8   C8x C    21.4200  -17.0100
            9   C8x C    20.0900  -17.4300
            10  C8x C    19.7400  -18.7600
            11  C8x C    20.7200  -19.7400
            12  C8x C    26.6000  -19.8800
            13  C8x C    27.6500  -18.9000
            14  C8x C    27.3700  -17.5700
            15  C8x C    26.0400  -17.1500
            16  C2b C    23.6600  -16.0300
            17  C1b C    24.9200  -15.4000
            18  C1b C    26.1100  -16.1000
            19  N1b N    27.3000  -15.4000
            20  C1a C    28.5600  -16.1000
BOND        22
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    7  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17    6  15 2
            18    4  16 2
            19   16  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1

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