KEGG   DRUG: D08291Help
Entry
D08291                      Drug                                   

Name
Ofloxacin hydrochloride;
Tarivid (TN)
Formula
C18H20FN3O4. xHCl
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibiotic, gyrase inhibitor
Remark
ATC code: 
Drug group: 
Target
DNA gyrase inhibitor [KO:K02469 K02470];
topoisomerase IV inhibitor [KO:K02621 K02622]
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Quinolones
Other map
Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01M QUINOLONE ANTIBACTERIALS
    J01MA Fluoroquinolones
     J01MA01 Ofloxacin
      D08291  Ofloxacin hydrochloride
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AE Fluoroquinolones
     S01AE01 Ofloxacin
      D08291  Ofloxacin hydrochloride
  S02 OTOLOGICALS
   S02A ANTIINFECTIVES
    S02AA Antiinfectives
     S02AA16 Ofloxacin
      D08291  Ofloxacin hydrochloride
USP drug classification [BR:br08302]
 Antibacterials
  Quinolones
   Ofloxacin
    D08291  Ofloxacin hydrochloride
Antiinfectives [BR:br08307]
 Antibacterials
  Nucleic acid synthesis inhibitor
   type II topoisomerase (DNA gyrase, topoisomerase IV) inhibitor
    Fluoroquinolones
     Ofloxacin
      D08291  Ofloxacin hydrochloride
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP3A4
   Ofloxacin
    D08291  Ofloxacin hydrochloride
BRITE hierarchy
Other DBs
CAS: 
118120-51-7
PubChem: 
LigandBox: 
KCF data Show

ATOM        27
            1   C8y C    25.4100  -18.2700
            2   C8y C    24.2200  -18.9700
            3   C8y C    25.4100  -16.8700
            4   N4y N    26.6000  -18.9700
            5   C8y C    22.9600  -18.2700
            6   O2x O    24.2200  -20.3700
            7   C8y C    26.6000  -16.1700
            8   C8x C    24.2200  -16.1700
            9   C8x C    27.8600  -18.2700
            10  C1y C    26.6000  -20.3700
            11  N1y N    21.7700  -18.9700
            12  C8y C    22.9600  -16.8700
            13  C1x C    25.4100  -21.0700
            14  C8y C    27.8600  -16.8700
            15  O5x O    26.6000  -14.7700
            16  C1a C    27.8600  -21.0700
            17  C1x C    20.5800  -18.2700
            18  C1x C    21.7700  -20.3700
            19  X   F    21.7700  -16.1700
            20  C6a C    29.0500  -16.1700
            21  C1x C    19.3200  -18.9700
            22  C1x C    20.5800  -21.0700
            23  O6a O    29.0500  -14.7700
            24  O6a O    30.2400  -16.8700
            25  N1y N    19.3200  -20.3700
            26  C1a C    18.1300  -21.0700
            27  X   Cl   33.5300  -20.3700
BOND        29
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 1
            9     4  10 1
            10    5  11 1
            11    5  12 1
            12    6  13 1
            13    7  14 1
            14    7  15 2
            15   10  16 1
            16   11  17 1
            17   11  18 1
            18   12  19 1
            19   14  20 1
            20   17  21 1
            21   18  22 1
            22   20  23 2
            23   20  24 1
            24   21  25 1
            25   25  26 1
            26    8  12 2
            27    9  14 2
            28   10  13 1
            29   22  25 1
BRACKET     1    31.9900  -21.1400   31.9900  -19.3900
            1    34.5800  -19.3900   34.5800  -21.1400
            1  x
 ORIGINAL  1   27
 REPEAT    1

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