KEGG   DRUG: Ofloxacin hydrochlorideHelp
Entry
D08291                      Drug                                   

Name
Ofloxacin hydrochloride;
Tarivid (TN)
Formula
C18H20FN3O4. xHCl
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antibacterial
 DG01550  Quinolone
  DG01549  Fluoroquinolone
Other
 DG01529  Topoisomerase inhibitor
  DG01528  Topoisomerase IV inhibitor
Cyp substrate
 DG01633  CYP3A substrate
Remark
ATC code: 
Chemical group: 
Activity
Antibacterial, Nucleic acid biosynthesis inhibitor
Comment
Fluoroquinolones
Target
DNA gyrase [KO:K02469 K02470];
topoisomerase IV [KO:K02621 K02622]
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Quinolones
Other map
Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01M QUINOLONE ANTIBACTERIALS
    J01MA Fluoroquinolones
     J01MA01 Ofloxacin
      D08291  Ofloxacin hydrochloride
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AE Fluoroquinolones
     S01AE01 Ofloxacin
      D08291  Ofloxacin hydrochloride
  S02 OTOLOGICALS
   S02A ANTIINFECTIVES
    S02AA Antiinfectives
     S02AA16 Ofloxacin
      D08291  Ofloxacin hydrochloride
USP drug classification [BR:br08302]
 Antibacterials
  Quinolones
   Ofloxacin
    D08291  Ofloxacin hydrochloride
Antiinfectives [BR:br08307]
 Antibacterials
  Nucleic acid synthesis inhibitor
   type II topoisomerase (DNA gyrase, topoisomerase IV) inhibitor
    Fluoroquinolones
     Ofloxacin
      D08291  Ofloxacin hydrochloride
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP3A4
   Ofloxacin
    D08291  Ofloxacin hydrochloride
BRITE hierarchy
Other DBs
CAS: 
118120-51-7
PubChem: 
LigandBox: 
KCF data Show

ATOM        27
            1   C8y C    25.4100  -18.2700
            2   C8y C    24.2200  -18.9700
            3   C8y C    25.4100  -16.8700
            4   N4y N    26.6000  -18.9700
            5   C8y C    22.9600  -18.2700
            6   O2x O    24.2200  -20.3700
            7   C8y C    26.6000  -16.1700
            8   C8x C    24.2200  -16.1700
            9   C8x C    27.8600  -18.2700
            10  C1y C    26.6000  -20.3700
            11  N1y N    21.7700  -18.9700
            12  C8y C    22.9600  -16.8700
            13  C1x C    25.4100  -21.0700
            14  C8y C    27.8600  -16.8700
            15  O5x O    26.6000  -14.7700
            16  C1a C    27.8600  -21.0700
            17  C1x C    20.5800  -18.2700
            18  C1x C    21.7700  -20.3700
            19  X   F    21.7700  -16.1700
            20  C6a C    29.0500  -16.1700
            21  C1x C    19.3200  -18.9700
            22  C1x C    20.5800  -21.0700
            23  O6a O    29.0500  -14.7700
            24  O6a O    30.2400  -16.8700
            25  N1y N    19.3200  -20.3700
            26  C1a C    18.1300  -21.0700
            27  X   Cl   33.5300  -20.3700
BOND        29
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 1
            9     4  10 1
            10    5  11 1
            11    5  12 1
            12    6  13 1
            13    7  14 1
            14    7  15 2
            15   10  16 1
            16   11  17 1
            17   11  18 1
            18   12  19 1
            19   14  20 1
            20   17  21 1
            21   18  22 1
            22   20  23 2
            23   20  24 1
            24   21  25 1
            25   25  26 1
            26    8  12 2
            27    9  14 2
            28   10  13 1
            29   22  25 1
BRACKET     1    31.9900  -21.1400   31.9900  -19.3900
            1    34.5800  -19.3900   34.5800  -21.1400
            1  x
 ORIGINAL  1   27
 REPEAT    1

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