KEGG   DRUG: D08293Help
Entry
D08293                      Drug                                   

Name
Olopatadine (INN);
Opatanol (TN)
Formula
C21H23NO3
Exact mass
337.1678
Mol weight
337.4122
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiallergic;
Histamine, H1-receptor antagonist
Remark
Same as: 
ATC code: 
Target
H1-receptor antagonist [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Interaction
Drug interaction
Structure map
Histamine H1 receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AC Antiallergic agents, excl. corticosteroids
     R01AC08 Olopatadine
      D08293  Olopatadine (INN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01G DECONGESTANTS AND ANTIALLERGICS
    S01GX Other antiallergics
     S01GX09 Olopatadine
      D08293  Olopatadine (INN)
USP drug classification [BR:br08302]
 Ophthalmic Agents
  Ophthalmic Anti-allergy Agents
   Olopatadine
    D08293  Olopatadine (INN)
 Respiratory Tract/Pulmonary Agents
  Antihistamines
   Olopatadine
    D08293  Olopatadine (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H1-receptor [HSA:3269] [KO:K04149]
     Olopatadine [ATC:R01AC08 S01GX09]
      D08293  Olopatadine (INN)
BRITE hierarchy
Other DBs
CAS: 
113806-05-6
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        25
            1   O2x O    19.4571  -20.5498
            2   C8y C    18.6155  -19.4276
            3   C8y C    18.8961  -18.0250
            4   C2y C    20.1585  -17.4639
            5   C1x C    20.8598  -20.5498
            6   C8y C    21.4209  -18.0951
            7   C8y C    21.7014  -19.4978
            8   C8x C    17.9141  -17.0430
            9   C8y C    16.5816  -17.4639
            10  C8x C    16.2309  -18.7965
            11  C8x C    17.2128  -19.7783
            12  C8x C    23.1041  -19.9185
            13  C8x C    24.0860  -18.9367
            14  C8x C    23.8054  -17.6041
            15  C8x C    22.4729  -17.1834
            16  C2b C    20.1585  -16.0612
            17  C1b C    15.5295  -16.4821
            18  C6a C    14.1970  -16.9028
            19  O6a O    13.2151  -15.9210
            20  O6a O    13.8464  -18.2354
            21  C1b C    18.9665  -15.3438
            22  C1b C    18.9665  -13.9446
            23  N1c N    17.7547  -13.2450
            24  C1a C    16.5641  -13.9322
            25  C1a C    17.7546  -11.8241
BOND        27
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    7  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17    6  15 2
            18    4  16 2
            19    9  17 1
            20   17  18 1
            21   18  19 1
            22   18  20 2
            23   16  21 1
            24   21  22 1
            25   22  23 1
            26   23  24 1
            27   23  25 1

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