KEGG   DRUG: D08297Help
Entry
D08297                      Drug                                   

Name
Opipramol (INN);
Opipramol dura (TN)
Formula
C23H29N3O
Exact mass
363.2311
Mol weight
363.4959
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antidepressant, tricyclic
Remark
ATC code: 
Drug group: 
Target
dopamine D2 receptor antagonist [HSA:1813] [KO:K04145];
5-HT2-receptor antagonist [HSA:3356 3357 3358] [KO:K04157];
H1-receptor antagonist [HSA:3269] [KO:K04149];
sigma-1 receptor agonist [HSA:10280]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse  
 
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06A ANTIDEPRESSANTS
    N06AA Non-selective monoamine reuptake inhibitors
     N06AA05 Opipramol
      D08297  Opipramol (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    dopamine D2-receptor
     Opipramol
      D08297  Opipramol (INN)
   Histamine
    H1-receptor
     Opipramol
      D08297  Opipramol (INN)
   Serotonin
    5-HT2-receptor
     Opipramol
      D08297  Opipramol (INN)
   Opioid
    sigma1-opioid receptor
     Opipramol
      D08297  Opipramol (INN)
BRITE hierarchy
Other DBs
CAS: 
315-72-0
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        27
            1   C2x C    20.4400  -21.5600
            2   C8y C    19.6000  -20.4400
            3   C8y C    19.8800  -19.0400
            4   N1y N    21.1400  -18.4800
            5   C2x C    21.8400  -21.5600
            6   C8y C    22.4000  -19.1100
            7   C8y C    22.7500  -20.5100
            8   C8x C    18.9000  -18.0600
            9   C8x C    17.5700  -18.4800
            10  C8x C    17.2200  -19.8100
            11  C8x C    18.2000  -20.7900
            12  C8x C    24.0800  -20.9300
            13  C8x C    25.1300  -19.9500
            14  C8x C    24.7800  -18.6200
            15  C8x C    23.4500  -18.2000
            16  C1b C    21.1400  -17.0800
            17  C1b C    22.3300  -16.4500
            18  C1b C    23.5200  -17.1500
            19  N1y N    24.7800  -16.4500
            20  C1x C    25.9700  -17.1500
            21  C1x C    27.2300  -16.5200
            22  N1y N    27.2300  -15.1200
            23  C1x C    25.9700  -14.3500
            24  C1x C    24.7800  -15.0500
            25  C1b C    28.4200  -14.4200
            26  C1b C    29.6100  -15.1200
            27  O1a O    30.8700  -14.4200
BOND        30
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    7  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17    6  15 2
            18    4  16 1
            19   16  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1
            23   20  21 1
            24   21  22 1
            25   22  23 1
            26   23  24 1
            27   19  24 1
            28   22  25 1
            29   25  26 1
            30   26  27 1

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