KEGG   DRUG: D08339Help
Entry
D08339                      Drug                                   

Name
Pergolide (INN);
Permax (TN)
Formula
C19H26N2S
Exact mass
314.1817
Mol weight
314.4881
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiparkinsonian, dopaminergic;
Lactation suppressant
Remark
Same as: 
ATC code: 
Comment
Ergot alkaloid derivatives
Target
dopamine D1-receptor agonist [HSA:1812] [KO:K04144];
dopamine D2-receptor agonist [HSA:1813] [KO:K04145]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04728  Dopaminergic synapse  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Drug interaction
Structure map
Antiparkinsonian agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N04 ANTI-PARKINSON DRUGS
   N04B DOPAMINERGIC AGENTS
    N04BC Dopamine agonists
     N04BC02 Pergolide
      D08339  Pergolide (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    dopamine D1-receptor [HSA:1812] [KO:K04144]
     Pergolide [ATC:N04BC02]
      D08339  Pergolide (INN)
    dopamine D2-receptor [HSA:1813] [KO:K04145]
     Pergolide [ATC:N04BC02]
      D08339  Pergolide (INN)
BRITE hierarchy
Other DBs
CAS: 
66104-22-1
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        22
            1   C8y C    21.7700  -20.6500
            2   C8y C    21.7700  -19.2500
            3   C8y C    22.9600  -21.2800
            4   C8y C    20.5800  -21.2800
            5   C1y C    22.9600  -18.5500
            6   C8x C    20.6500  -18.5500
            7   C1x C    24.1500  -20.6500
            8   C8x C    22.9600  -22.6800
            9   N4x N    20.5800  -22.6800
            10  C8x C    19.4600  -20.5800
            11  C1y C    24.1500  -19.2500
            12  C1x C    22.9600  -17.2200
            13  C8x C    19.4600  -19.2500
            14  N1y N    25.3400  -18.6200
            15  C1y C    24.1500  -16.5200
            16  C1x C    25.3400  -17.2200
            17  C1b C    26.5300  -19.2500
            18  C1b C    24.1500  -15.1900
            19  C1b C    27.7200  -18.6200
            20  S2a S    25.3400  -14.4900
            21  C1a C    28.8400  -19.3200
            22  C1a C    25.3400  -13.1600
BOND        25
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     3   8 2
            8     4   9 1
            9     4  10 1
            10    5  11 1
            11    5  12 1
            12    6  13 1
            13   11  14 1
            14   12  15 1
            15   14  16 1
            16   14  17 1
            17   15  18 1 #Up
            18   17  19 1
            19   18  20 1
            20   19  21 1
            21   20  22 1
            22    7  11 1
            23    8   9 1
            24   10  13 2
            25   15  16 1

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