KEGG   DRUG: D08340Help
Entry
D08340                      Drug                                   

Name
Perhexiline (INN)
Formula
C19H35N
Exact mass
277.277
Mol weight
277.4879
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Coronary vasodilator;
Calcium antagonist
Remark
ATC code: 
Drug group: 
Target
L-type calcium channel blocker [HSA:775 776 778 779] [KO:K04850 K04851 K04853 K04857];
carnitine palmitoyltransferase (CPT) inhibitor [HSA:1374 1375 126129 1376] [KO:K08765 K08766]
  Pathway
hsa04260  Cardiac muscle contraction
hsa04270  Vascular smooth muscle contraction  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C08 CALCIUM CHANNEL BLOCKERS
   C08E NON-SELECTIVE CALCIUM CHANNEL BLOCKERS
    C08EX Other non-selective calcium channel blockers
     C08EX02 Perhexiline
      D08340  Perhexiline (INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Ca2+ channel, CACN alpha-1, CaVx.x
    calcium channel L type
     Perhexiline
      D08340  Perhexiline (INN)
 Enzymes
  Transferases
   carnitine palmitoyltransferase (CPT) 1
    Perhexiline
     D08340  Perhexiline (INN)
   carnitine palmitoyltransferase (CPT) 2
    Perhexiline
     D08340  Perhexiline (INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Perhexiline
    D08340  Perhexiline (INN)
BRITE hierarchy
Other DBs
CAS: 
6621-47-2
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        20
            1   C1x C    20.5800  -19.3200
            2   C1x C    20.5800  -20.7200
            3   C1x C    21.7700  -21.4200
            4   C1x C    22.9600  -20.7200
            5   C1y C    22.9600  -19.3200
            6   C1x C    21.7700  -18.6200
            7   C1x C    25.4100  -20.7200
            8   C1y C    25.4100  -19.3200
            9   C1c C    24.1500  -18.6200
            10  C1x C    26.6000  -21.4200
            11  C1x C    27.7900  -20.7200
            12  C1x C    27.7900  -19.3200
            13  C1x C    26.6000  -18.6200
            14  C1b C    24.1500  -17.2200
            15  C1y C    25.4100  -16.5200
            16  N1x N    26.6000  -17.2200
            17  C1x C    27.7900  -16.5200
            18  C1x C    27.7900  -15.1200
            19  C1x C    26.6000  -14.4200
            20  C1x C    25.4100  -15.1200
BOND        22
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     7   8 1
            8     8   9 1
            9     5   9 1
            10    7  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14    8  13 1
            15    9  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 1
            19   17  18 1
            20   18  19 1
            21   19  20 1
            22   15  20 1

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