KEGG   DRUG: D08351Help
Entry
D08351                      Drug                                   

Name
Phenformin (BAN)
Formula
C10H15N5
Exact mass
205.1327
Mol weight
205.2596
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antidiabetic [DS:H00409]
Remark
Same as: 
ATC code: 
Drug group: 
Comment
biguanides
Target
AMPK activator [HSA:5562 5563] [KO:K07198]
  Pathway
hsa04140  Regulation of autophagy
hsa04150  mTOR signaling pathway
hsa04910  Insulin signaling pathway
hsa04920  Adipocytokine signaling pathway  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Drug interaction
Other map
AMPK signaling pathway
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BA Biguanides
     A10BA01 Phenformin
      D08351  Phenformin (BAN)
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Serine/threonine protein kinases: CAMK group
   CAMKL family
    AMPK
     Phenformin
      D08351  Phenformin (BAN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Phenformin
    D08351  Phenformin (BAN)
BRITE hierarchy
Other DBs
CAS: 
114-86-3
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        15
            1   C8y C    25.0600  -18.8300
            2   C1b C    26.2500  -18.1300
            3   C8x C    25.0600  -20.2300
            4   C8x C    23.8700  -18.1300
            5   C1b C    27.5100  -18.8300
            6   C8x C    23.8700  -20.9300
            7   C8x C    22.6100  -18.8300
            8   N1b N    28.6300  -18.1300
            9   C8x C    22.6100  -20.2300
            10  C2c C    29.8200  -18.8300
            11  N1b N    31.0800  -18.1300
            12  N2a N    29.8200  -20.2300
            13  C2c C    32.2700  -18.8300
            14  N1a N    33.4600  -18.1300
            15  N2a N    32.2700  -20.2300
BOND        15
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     4   7 2
            7     5   8 1
            8     6   9 2
            9     8  10 1
            10   10  11 1
            11   10  12 2
            12   11  13 1
            13   13  14 1
            14   13  15 2
            15    7   9 1

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