KEGG   DRUG: Phenformin hydrochlorideHelp
Entry
D08352                      Drug                                   

Name
Phenformin hydrochloride;
Debei (TN)
Formula
C10H15N5. HCl
Exact mass
241.1094
Mol weight
241.7205
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antidiabetic agent
 DG01685  Insulin sensitizer
  DG01684  Biguanide antidiabetic
Cyp substrate
 DG01644  CYP2D6 substrate
Remark
ATC code: 
Chemical group: 
Activity
Antidiabetic
Comment
biguanides
Target
AMPK activator [HSA:5562 5563] [KO:K07198]
  Pathway
Regulation of autophagy
mTOR signaling pathway
Insulin signaling pathway
Adipocytokine signaling pathway
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BA Biguanides
     A10BA01 Phenformin
      D08352  Phenformin hydrochloride
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Serine/threonine protein kinases: CAMK group
   CAMKL family
    AMPK
     Phenformin
      D08352  Phenformin hydrochloride
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP2D6
   Phenformin
    D08352  Phenformin hydrochloride
BRITE hierarchy
Other DBs
CAS: 
834-28-6
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        16
            1   C8y C    19.8800  -15.4700
            2   C1b C    18.6900  -14.7700
            3   C8x C    19.8800  -16.8700
            4   C8x C    21.0700  -14.7700
            5   C1b C    17.4300  -15.4700
            6   C8x C    21.0700  -17.5700
            7   C8x C    22.3300  -15.4700
            8   N1b N    16.2400  -14.7700
            9   C8x C    22.3300  -16.8700
            10  C2c C    15.0500  -15.4700
            11  N1b N    13.7900  -14.7700
            12  N2a N    15.0500  -16.8700
            13  C2c C    12.6000  -15.4700
            14  N1a N    11.4800  -14.7700
            15  N2a N    12.6000  -16.8700
            16  X   Cl   24.3600  -16.0300
BOND        15
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     4   7 2
            7     5   8 1
            8     6   9 2
            9     8  10 1
            10   10  11 1
            11   10  12 2
            12   11  13 1
            13   13  14 1
            14   13  15 2
            15    7   9 1

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