KEGG   DRUG: D08358Help
Entry
D08358                      Drug                                   

Name
Phenoxybenzamine (INN)
Formula
C18H22ClNO
Exact mass
303.139
Mol weight
303.8264
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihypertensive;
Vasodilator, peripheric;
alfa-Adrenergic blocking
Remark
Same as: 
ATC code: 
Drug group: 
Target
alpha1-adrenergic receptor antagonist [HSA:146 147 148] [KO:K04137 K04136 K04135];
alpha2-adrenergic receptor antagonist [HSA:150 151 152] [KO:K04138 K04139 K04140]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04970  Salivary secretion  
 
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C04 PERIPHERAL VASODILATORS
   C04A PERIPHERAL VASODILATORS
    C04AX Other peripheral vasodilators
     C04AX02 Phenoxybenzamine
      D08358  Phenoxybenzamine (INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Alpha-adrenergic Blocking Agents
   Phenoxybenzamine
    D08358  Phenoxybenzamine (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor
     Phenoxybenzamine
      D08358  Phenoxybenzamine (INN)
    alpha2-adrenergic receptor
     Phenoxybenzamine
      D08358  Phenoxybenzamine (INN)
BRITE hierarchy
Other DBs
CAS: 
59-96-1
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        21
            1   C8x C    19.7400  -19.1100
            2   C8x C    19.7400  -20.5100
            3   C8x C    20.9524  -21.2100
            4   C8y C    22.1649  -20.5100
            5   C8x C    22.1649  -19.1100
            6   C8x C    20.9524  -18.4100
            7   C1b C    23.3960  -21.2210
            8   N1c N    24.6012  -20.5253
            9   C1c C    25.7835  -21.2081
            10  C1b C    26.9775  -20.5188
            11  C1a C    25.7835  -22.6098
            12  C1b C    24.6016  -19.1104
            13  C1b C    25.7905  -18.4241
            14  X   Cl   25.7910  -17.0103
            15  O2a O    28.1654  -21.2048
            16  C8y C    29.3565  -20.5171
            17  C8x C    30.5459  -21.2039
            18  C8x C    31.7584  -20.5040
            19  C8x C    31.7585  -19.1040
            20  C8x C    30.5691  -18.4172
            21  C8x C    29.3566  -19.1171
BOND        22
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    9  11 1
            12    8  12 1
            13   12  13 1
            14   13  14 1
            15   10  15 1
            16   15  16 1
            17   16  17 2
            18   17  18 1
            19   18  19 2
            20   19  20 1
            21   20  21 2
            22   16  21 1

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