KEGG   DRUG: Pilocarpine borateHelp
Entry
D08376                      Drug                                   

Name
Pilocarpine borate;
pilolarpin ophtha (TN)
Formula
C11H16N2O2. xH3BO3
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Neuropsychiatric agent
 DG01490  Muscarinic cholinergic receptor agonist
Other
 DG01719  Parasympathomimetic agent
Cyp substrate
 DG01638  CYP2A6 substrate
Remark
ATC code: 
Chemical group: 
Activity
Parasympathomimetic
Target
muscarinic cholinergic receptor [HSA:1128 1129 1131 1132 1133] [KO:K04129 K04130 K04131 K04132 K04133]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Metabolism
Enzyme: CYP2A6 [HSA:1548]
Interaction
Drug interaction
Structure map
Antiglaucoma agents
Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07A PARASYMPATHOMIMETICS
    N07AX Other parasympathomimetics
     N07AX01 Pilocarpine
      D08376  Pilocarpine borate
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EB Parasympathomimetics
     S01EB01 Pilocarpine
      D08376  Pilocarpine borate
USP drug classification [BR:br08302]
 Dental and Oral Agents
  Pilocarpine
   D08376  Pilocarpine borate
 Ophthalmic Agents
  Ophthalmic Antiglaucoma Agents
   Pilocarpine
    D08376  Pilocarpine borate
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    muscarinic cholinergic receptor
     Pilocarpine
      D08376  Pilocarpine borate
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP2A6
   Pilocarpine
    D08376  Pilocarpine borate
Phytochemicals used as drugs [BR:br08306]
 Alkaloids
  Alkaloids derived from histidine
   Imidazole alkaloids
    D08376  Pilocarpine borate
BRITE hierarchy
Other DBs
CAS: 
16509-56-1
PubChem: 
LigandBox: 
KCF data Show

ATOM        19
            1   C1y C    18.3400  -18.5500
            2   C1y C    16.8700  -18.5500
            3   C1b C    19.5300  -19.2500
            4   C1x C    18.7600  -17.2200
            5   C7x C    16.4500  -17.2200
            6   C1b C    16.1000  -19.7400
            7   C8y C    20.5800  -18.6200
            8   O7x O    17.6400  -16.3800
            9   O6a O    15.1200  -16.8000
            10  C1a C    14.7000  -19.7400
            11  N4y N    22.0500  -18.6200
            12  C8x C    20.1600  -17.2200
            13  C8x C    22.4700  -17.2200
            14  C1a C    22.8200  -19.7400
            15  N5x N    21.2800  -16.3800
            16  Z   B    29.8900  -18.4800
            17  O1a O    29.8900  -17.0800
            18  O1a O    28.6776  -19.1800
            19  O1a O    31.1024  -19.1800
BOND        19
            1     1   2 1
            2     1   3 1 #Down
            3     1   4 1
            4     2   5 1
            5     2   6 1 #Down
            6     3   7 1
            7     4   8 1
            8     5   9 2
            9     6  10 1
            10    7  11 1
            11    7  12 2
            12   11  13 1
            13   11  14 1
            14   12  15 1
            15    5   8 1
            16   13  15 2
            17   16  17 1
            18   16  18 1
            19   16  19 1
BRACKET     1    26.8800  -19.8100   26.8800  -16.0300
            1    32.9000  -16.0300   32.9000  -19.8100
            1  x
 ORIGINAL  1   16  17  18  19
 REPEAT    1

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