KEGG   DRUG: D08376Help
Entry
D08376                      Drug                                   

Name
Pilocarpine borate;
pilolarpin ophtha (TN)
Formula
C11H16N2O2. xH3BO3
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Parasympathomimetic, direct acting
Remark
ATC code: 
Drug group: 
Target
muscarinic cholinergic receptor agonist [HSA:1128 1129 1131 1132 1133] [KO:K04129 K04130 K04131 K04132 K04133]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa04970  Salivary secretion
hsa04971  Gastric acid secretion
hsa04972  Pancreatic secretion  
 
Metabolism
Enzyme: CYP2A6 [HSA:1548]
Interaction
Drug interaction
Structure map
Antiglaucoma agents
Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07A PARASYMPATHOMIMETICS
    N07AX Other parasympathomimetics
     N07AX01 Pilocarpine
      D08376  Pilocarpine borate
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EB Parasympathomimetics
     S01EB01 Pilocarpine
      D08376  Pilocarpine borate
USP drug classification [BR:br08302]
 Dental and Oral Agents
  Pilocarpine
   D08376  Pilocarpine borate
 Ophthalmic Agents
  Ophthalmic Antiglaucoma Agents
   Pilocarpine
    D08376  Pilocarpine borate
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    muscarinic cholinergic receptor
     Pilocarpine
      D08376  Pilocarpine borate
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2A6
   Pilocarpine
    D08376  Pilocarpine borate
Phytochemicals used as drugs [BR:br08306]
 Alkaloids
  Alkaloids derived from histidine
   Imidazole alkaloids
    D08376  Pilocarpine borate
BRITE hierarchy
Other DBs
CAS: 
16509-56-1
PubChem: 
LigandBox: 
KCF data Show

ATOM        19
            1   C1y C    18.3400  -18.5500
            2   C1y C    16.8700  -18.5500
            3   C1b C    19.5300  -19.2500
            4   C1x C    18.7600  -17.2200
            5   C7x C    16.4500  -17.2200
            6   C1b C    16.1000  -19.7400
            7   C8y C    20.5800  -18.6200
            8   O7x O    17.6400  -16.3800
            9   O6a O    15.1200  -16.8000
            10  C1a C    14.7000  -19.7400
            11  N4y N    22.0500  -18.6200
            12  C8x C    20.1600  -17.2200
            13  C8x C    22.4700  -17.2200
            14  C1a C    22.8200  -19.7400
            15  N5x N    21.2800  -16.3800
            16  Z   B    29.8900  -18.4800
            17  O1a O    29.8900  -17.0800
            18  O1a O    28.6776  -19.1800
            19  O1a O    31.1024  -19.1800
BOND        19
            1     1   2 1
            2     1   3 1 #Down
            3     1   4 1
            4     2   5 1
            5     2   6 1 #Down
            6     3   7 1
            7     4   8 1
            8     5   9 2
            9     6  10 1
            10    7  11 1
            11    7  12 2
            12   11  13 1
            13   11  14 1
            14   12  15 1
            15    5   8 1
            16   13  15 2
            17   16  17 1
            18   16  18 1
            19   16  19 1
BRACKET     1    26.8800  -19.8100   26.8800  -16.0300
            1    32.9000  -16.0300   32.9000  -19.8100
            1  x
 ORIGINAL  1   16  17  18  19
 REPEAT    1

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