KEGG   DRUG: D08377Help
Entry
D08377                      Drug                                   

Name
Pilsicainide (INN)
Formula
C17H24N2O
Exact mass
272.1889
Mol weight
272.3853
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiarrhythmic
Comment
Class I antiarrhythmic agent (Ic)
Target
voltage-gated potassium channel (KCNA1) blocker [HSA:3736] [KO:K04874];
voltage-gated potassium channel (KCNA2) blocker [HSA:3737] [KO:K04875];
voltage-gated potassium channel (KCNA5) blocker [HSA:3741] [KO:K04878];
voltage-gated potassium channel (KCNA7) blocker [HSA:3743] [KO:K04880];
voltage-gated potassium channel (KCNC1) blocker [HSA:3746] [KO:K04887];
voltage-gated sodium channel (SCN1A) blocker [HSA:6323] [KO:K04833];
voltage-gated sodium channel (SCN2A) blocker [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN3A) blocker [HSA:6328] [KO:K04836];
voltage-gated sodium channel (SCN4A) blocker [HSA:6329] [KO:K04837];
voltage-gated sodium channel (SCN5A) blocker [HSA:6331] [KO:K04838];
voltage-gated sodium channel (SCN8A) blocker [HSA:6334] [KO:K04840];
voltage-gated sodium channel (SCN9A) blocker [HSA:6335] [KO:K04841]
Interaction
Transporter inhibition: SLC22A2 [HSA:6582]
Drug interaction
Structure map
Antiarrhythmic drugs
Sodium channel blocking drugs
Brite
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A) [HSA:6323] [KO:K04833]
     Pilsicainide
      D08377  Pilsicainide (INN)
    voltage-gated sodium channel (SCN2A) [HSA:6326] [KO:K04834]
     Pilsicainide
      D08377  Pilsicainide (INN)
    voltage-gated sodium channel (SCN3A) [HSA:6328] [KO:K04836]
     Pilsicainide
      D08377  Pilsicainide (INN)
    voltage-gated sodium channel (SCN4A) [HSA:6329] [KO:K04837]
     Pilsicainide
      D08377  Pilsicainide (INN)
    voltage-gated sodium channel (SCN5A) [HSA:6331] [KO:K04838]
     Pilsicainide
      D08377  Pilsicainide (INN)
    voltage-gated sodium channel (SCN8A) [HSA:6334] [KO:K04840]
     Pilsicainide
      D08377  Pilsicainide (INN)
    voltage-gated sodium channel (SCN9A) [HSA:6335] [KO:K04841]
     Pilsicainide
      D08377  Pilsicainide (INN)
   K+ channel, KCNA, Kv1.x (Shaker)
    voltage-gated potassium channel (KCNA1) [HSA:3736] [KO:K04874]
     Pilsicainide
      D08377  Pilsicainide (INN)
    voltage-gated potassium channel (KCNA2) [HSA:3737] [KO:K04875]
     Pilsicainide
      D08377  Pilsicainide (INN)
    voltage-gated potassium channel (KCNA5) [HSA:3741] [KO:K04878]
     Pilsicainide
      D08377  Pilsicainide (INN)
    voltage-gated potassium channel (KCNA7) [HSA:3743] [KO:K04880]
     Pilsicainide
      D08377  Pilsicainide (INN)
   K+ channel, KCNC, Kv3.x (Shaw)
    voltage-gated potassium channel (KCNC1) [HSA:3746] [KO:K04887]
     Pilsicainide
      D08377  Pilsicainide (INN)
BRITE hierarchy
Other DBs
CAS: 
88069-67-4
PubChem: 
LigandBox: 
KCF data Show

ATOM        20
            1   C8y C    25.8300  -17.0100
            2   C8y C    27.0200  -17.7100
            3   C8x C    28.2800  -17.0100
            4   C8x C    28.2800  -15.6100
            5   C8x C    27.0200  -14.9100
            6   C8y C    25.8300  -15.6100
            7   N1y N    22.1900  -20.5100
            8   C1z C    22.1900  -19.1100
            9   C1x C    23.5200  -20.9300
            10  C1x C    20.8600  -20.9300
            11  C1x C    23.5200  -18.6200
            12  C1x C    20.8600  -18.6200
            13  C1x C    24.3600  -19.8100
            14  C1x C    20.0200  -19.8100
            15  C1b C    22.1900  -17.7100
            16  C5a C    23.3800  -17.0100
            17  O5a O    23.3800  -15.6100
            18  N1b N    24.6400  -17.7100
            19  C1a C    24.6400  -14.9100
            20  C1a C    27.0200  -19.1100
BOND        22
            1     6   1 1
            2     7   8 1
            3     7   9 1
            4     7  10 1
            5     8  11 1
            6     8  12 1
            7     9  13 1
            8    10  14 1
            9    11  13 1
            10   12  14 1
            11    8  15 1
            12   15  16 1
            13    1   2 2
            14   16  17 2
            15    2   3 1
            16   16  18 1
            17   18   1 1
            18    3   4 2
            19    6  19 1
            20    4   5 1
            21    2  20 1
            22    5   6 2

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