KEGG   DRUG: D08378Help
Entry
D08378                      Drug                                   

Name
Pioglitazone (INN);
Actos (TN)
Formula
C19H20N2O3S
Exact mass
356.1195
Mol weight
356.4387
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antidiabetic [DS:H00409]
Remark
Same as: 
ATC code: 
Target
peroxisome proliferator-activated receptor (PPAR) gamma agonist [HSA:5468] [KO:K08530]
  Pathway
hsa03320  PPAR signaling pathway  
 
Interaction
CYP induction: CYP3A [HSA:1576 1577 1551]
Drug interaction
Structure map
Antidiabetics
Peroxisome proliferator-activated receptor (PPAR) agonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BG Thiazolidinediones
     A10BG03 Pioglitazone
      D08378  pioglitazone (INN)
USP drug classification [BR:br08302]
 Blood Glucose Regulators
  Antidiabetic Agents
   Pioglitazone
    D08378  pioglitazone (INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Thyroid hormone like receptors
   Peroxisome proliferator-activated receptor (PPAR)
    peroxisome proliferator-activated receptor (PPAR) gamma [HSA:5468] [KO:K08530]
     Pioglitazone [ATC:A10BG03]
      D08378  pioglitazone (INN)
BRITE hierarchy
Other DBs
CAS: 
111025-46-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        25
            1   C1y C    32.9700  -20.3700
            2   C1b C    31.7800  -19.6700
            3   C8y C    30.5900  -20.3700
            4   C8x C    29.3300  -19.6700
            5   C8x C    30.5900  -21.7700
            6   C8x C    28.1400  -20.3700
            7   C8x C    29.3300  -22.4700
            8   C8y C    28.1400  -21.7700
            9   O2a O    26.9500  -22.4700
            10  C1b C    25.6900  -21.7700
            11  C1b C    24.5700  -22.4700
            12  C8y C    23.3800  -21.7700
            13  C8x C    23.3800  -20.3700
            14  N5x N    22.1900  -22.4700
            15  C8x C    22.1900  -19.6700
            16  C8x C    20.9300  -21.7700
            17  C8y C    20.9300  -20.3700
            18  C1b C    19.7400  -19.6700
            19  C1a C    18.5500  -20.3700
            20  C5x C    32.9698  -21.7700
            21  N1x N    34.3013  -22.2028
            22  C5x C    35.1243  -21.0703
            23  S2x S    34.3015  -19.9375
            24  O5x O    36.5400  -21.0704
            25  O5x O    31.8372  -22.5927
BOND        27
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     3   5 1
            5     4   6 1
            6     5   7 2
            7     6   8 2
            8     8   9 1
            9     9  10 1
            10   10  11 1
            11   11  12 1
            12   12  13 2
            13   12  14 1
            14   13  15 1
            15   14  16 2
            16   15  17 2
            17   17  18 1
            18   18  19 1
            19    7   8 1
            20   16  17 1
            21    1  20 1
            22   20  21 1
            23   21  22 1
            24   22  23 1
            25    1  23 1
            26   22  24 2
            27   20  25 2

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