KEGG   DRUG: PioglitazoneHelp
Entry
D08378                      Drug                                   

Name
Pioglitazone (INN);
Actos (TN)
Formula
C19H20N2O3S
Exact mass
356.1195
Mol weight
356.4387
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antidiabetic agent
 DG01685  Insulin sensitizer
  DG01795  PPAR gamma agonist
   DG01683  Thiazolidinedione
Other
 DG01733  PPAR agonist
  DG01683  Thiazolidinedione
Cyp inducer
 DG01635  CYP3A4 inducer
 DG01897  CYP3A5 inducer
Remark
Same as: 
ATC code: 
Chemical group: 
Activity
Antidiabetic
Target
peroxisome proliferator-activated receptor (PPAR) gamma [HSA:5468] [KO:K08530]
  Pathway
PPAR signaling pathway
Interaction
CYP induction: CYP3A [HSA:1576 1577 1551]
Drug interaction
Structure map
Antidiabetics
Peroxisome proliferator-activated receptor (PPAR) agonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BG Thiazolidinediones
     A10BG03 Pioglitazone
      D08378  Pioglitazone (INN)
USP drug classification [BR:br08302]
 Blood Glucose Regulators
  Antidiabetic Agents
   Pioglitazone
    D08378  Pioglitazone (INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Thyroid hormone like receptors
   Peroxisome proliferator-activated receptor (PPAR)
    peroxisome proliferator-activated receptor (PPAR) gamma
     Pioglitazone
      D08378  Pioglitazone (INN)
Cytochrome P450 interactions [BR:br08309]
 CYP inducers
  CYP3A
   Pioglitazone
    D08378  Pioglitazone (INN)
 CYP substrates
  CYP2C8
   Pioglitazone
    D08378  Pioglitazone (INN)
BRITE hierarchy
Other DBs
CAS: 
111025-46-8
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        25
            1   C1y C    32.9700  -20.3700
            2   C1b C    31.7800  -19.6700
            3   C8y C    30.5900  -20.3700
            4   C8x C    29.3300  -19.6700
            5   C8x C    30.5900  -21.7700
            6   C8x C    28.1400  -20.3700
            7   C8x C    29.3300  -22.4700
            8   C8y C    28.1400  -21.7700
            9   O2a O    26.9500  -22.4700
            10  C1b C    25.6900  -21.7700
            11  C1b C    24.5700  -22.4700
            12  C8y C    23.3800  -21.7700
            13  C8x C    23.3800  -20.3700
            14  N5x N    22.1900  -22.4700
            15  C8x C    22.1900  -19.6700
            16  C8x C    20.9300  -21.7700
            17  C8y C    20.9300  -20.3700
            18  C1b C    19.7400  -19.6700
            19  C1a C    18.5500  -20.3700
            20  C5x C    32.9698  -21.7700
            21  N1x N    34.3013  -22.2028
            22  C5x C    35.1243  -21.0703
            23  S2x S    34.3015  -19.9375
            24  O5x O    36.5400  -21.0704
            25  O5x O    31.8372  -22.5927
BOND        27
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     3   5 1
            5     4   6 1
            6     5   7 2
            7     6   8 2
            8     8   9 1
            9     9  10 1
            10   10  11 1
            11   11  12 1
            12   12  13 2
            13   12  14 1
            14   13  15 1
            15   14  16 2
            16   15  17 2
            17   17  18 1
            18   18  19 1
            19    7   8 1
            20   16  17 1
            21    1  20 1
            22   20  21 1
            23   21  22 1
            24   22  23 1
            25    1  23 1
            26   22  24 2
            27   20  25 2

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