KEGG   DRUG: D08394Help
Entry
D08394                      Drug                                   

Name
Pirmenol (INN)
Formula
C22H30N2O
Exact mass
338.2358
Mol weight
338.4864
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiarrhythmic
Remark
Drug group: 
Comment
Class I antiarrhythmic agent (Ia)
Target
voltage-gated sodium channel (SCN1A) blocker [HSA:6323] [KO:K04833];
voltage-gated sodium channel (SCN2A) blocker [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN3A) blocker [HSA:6328] [KO:K04836];
voltage-gated sodium channel (SCN4A) blocker [HSA:6329] [KO:K04837];
voltage-gated sodium channel (SCN5A) blocker [HSA:6331] [KO:K04838];
voltage-gated sodium channel (SCN8A) blocker [HSA:6334] [KO:K04840];
voltage-gated sodium channel (SCN9A) blocker [HSA:6335] [KO:K04841]
Interaction
Drug interaction
Structure map
Antiarrhythmic drugs
Sodium channel blocking drugs
Brite
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Pirmenol
      D08394  Pirmenol (INN)
    voltage-gated sodium channel (SCN2A)
     Pirmenol
      D08394  Pirmenol (INN)
    voltage-gated sodium channel (SCN3A)
     Pirmenol
      D08394  Pirmenol (INN)
    voltage-gated sodium channel (SCN4A)
     Pirmenol
      D08394  Pirmenol (INN)
    voltage-gated sodium channel (SCN5A)
     Pirmenol
      D08394  Pirmenol (INN)
    voltage-gated sodium channel (SCN8A)
     Pirmenol
      D08394  Pirmenol (INN)
    voltage-gated sodium channel (SCN9A)
     Pirmenol
      D08394  Pirmenol (INN)
BRITE hierarchy
Other DBs
CAS: 
68252-19-7
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        25
            1   C8x C    19.9500  -20.3700
            2   C8x C    19.9500  -21.7700
            3   C8x C    21.1400  -22.4700
            4   C8x C    22.3300  -21.7700
            5   C8y C    22.3300  -20.3700
            6   C8x C    21.1400  -19.6700
            7   C1d C    23.5900  -19.6700
            8   C8y C    24.7800  -20.3700
            9   C8x C    24.7800  -21.7700
            10  C8x C    25.9700  -22.4700
            11  C8x C    27.2300  -21.7700
            12  C8x C    27.2300  -20.3700
            13  N5x N    25.9700  -19.6700
            14  C1b C    23.5900  -18.2700
            15  C1b C    24.7800  -17.5700
            16  C1b C    24.7800  -16.1700
            17  N1y N    25.9700  -15.4700
            18  C1y C    27.2300  -16.1700
            19  C1x C    28.4200  -15.4700
            20  C1x C    28.4200  -14.0700
            21  C1x C    27.2300  -13.3700
            22  C1y C    25.9700  -14.0700
            23  C1a C    24.7800  -13.3700
            24  C1a C    27.2300  -17.5700
            25  O1a O    22.4000  -18.9700
BOND        27
            1    11  12 1
            2    12  13 2
            3    13   8 1
            4     6   1 1
            5     7  14 1
            6    14  15 1
            7     5   7 1
            8    15  16 1
            9    16  17 1
            10    7   8 1
            11    1   2 2
            12    2   3 1
            13    3   4 2
            14    4   5 1
            15    5   6 2
            16   17  18 1
            17   18  19 1
            18   19  20 1
            19   20  21 1
            20   21  22 1
            21   22  17 1
            22    8   9 2
            23   22  23 1 #Down
            24    9  10 1
            25   18  24 1 #Down
            26   10  11 2
            27    7  25 1

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