KEGG   DRUG: D08397Help
Entry
D08397                      Drug                                   

Name
Pizotifen malate;
Mosegor (TN);
Sandomigran (TN)
Formula
C19H21NS. C4H6O5
Exact mass
429.161
Mol weight
429.5292
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antimigraine;
Serotonin antagonist
Remark
ATC code: 
Drug group: 
Target
5-HT2A-receptor antagonist [HSA:3356] [KO:K04157];
5-HT2C-receptor antagonist [HSA:3358] [KO:K04157];
5-HT1-receptor antagonist [HSA:3350 3351 3352 3354 3355] [KO:K04153]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse  
 
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02C ANTIMIGRAINE PREPARATIONS
    N02CX Other antimigraine preparations
     N02CX01 Pizotifen
      D08397  Pizotifen malate
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Serotonin
    5-HT1-receptor
     Pizotifen
      D08397  Pizotifen malate
    5-HT2A-receptor
     Pizotifen
      D08397  Pizotifen malate
    5-HT2C-receptor
     Pizotifen
      D08397  Pizotifen malate
BRITE hierarchy
Other DBs
CAS: 
5189-11-7
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        30
            1   C1x C    19.3900  -22.2600
            2   C8y C    18.5500  -21.1400
            3   C8y C    18.9000  -19.7400
            4   C2y C    20.1600  -19.1800
            5   C1x C    20.8600  -22.2600
            6   C8y C    21.4200  -19.8100
            7   C8y C    21.7000  -21.2100
            8   C8x C    17.9200  -18.8300
            9   C8x C    16.5200  -19.1800
            10  C8x C    16.2400  -20.5800
            11  C8x C    17.2200  -21.5600
            12  S2x S    23.1000  -21.2100
            13  C8x C    23.7300  -20.0900
            14  C8x C    22.6800  -19.1100
            15  C2y C    20.1600  -17.7800
            16  C1x C    21.3500  -17.0800
            17  C1x C    21.3500  -15.6800
            18  N1y N    20.1600  -14.9800
            19  C1x C    18.9700  -15.6800
            20  C1x C    18.9700  -17.0800
            21  C1a C    20.1600  -13.5800
            22  O6a O    27.2300  -18.3400
            23  C6a C    28.4424  -19.0400
            24  C1c C    29.6549  -18.3400
            25  C1b C    30.8673  -19.0400
            26  C6a C    32.0797  -18.3400
            27  O6a O    33.2922  -19.0400
            28  O6a O    28.4424  -20.4398
            29  O1a O    29.6549  -16.9402
            30  O6a O    32.0797  -16.9401
BOND        32
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 2
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    7  12 1
            14   12  13 1
            15   13  14 2
            16    6  14 1
            17    4  15 2
            18   15  16 1
            19   16  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1
            23   15  20 1
            24   18  21 1
            25   22  23 1
            26   23  24 1
            27   24  25 1
            28   25  26 1
            29   26  27 1
            30   23  28 2
            31   24  29 1
            32   26  30 2

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