KEGG   DRUG: D08408Help
Entry
D08408                      Drug                                   

Name
Pranlukast (INN);
Azlaire (TN)
Formula
C27H23N5O4
Exact mass
481.175
Mol weight
481.5026
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiasthmatic;
Antiinflammatory;
Leukotrien-receptor antagonist  [DS:H00079]
Remark
ATC code: 
Drug group: 
Target
cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist [HSA:10800] [KO:K04322];
cysteinyl leukotriene receptor 2 (CYSLTR2) antagonist [HSA:57105] [KO:K04323]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Eicosanoids
Eicosanoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03D OTHER SYSTEMIC DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
    R03DC Leukotriene receptor antagonists
     R03DC02 Pranlukast
      D08408  Pranlukast (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Cysteinyl leukotriene
    cysteinyl leukotriene receptor 1
     Pranlukast
      D08408  Pranlukast (INN)
    cysteinyl leukotriene receptor 2
     Pranlukast
      D08408  Pranlukast (INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP3A4
   Pranlukast
    D08408  Pranlukast (INN)
BRITE hierarchy
Other DBs
CAS: 
103177-37-3
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        36
            1   C8y C    22.3300  -19.3200
            2   C8x C    23.5200  -20.0900
            3   C8x C    24.7800  -19.3200
            4   C8y C    24.7800  -17.9200
            5   C8x C    23.5200  -17.2200
            6   C8x C    22.3300  -17.9200
            7   C5a C    21.1400  -20.0900
            8   N1b N    19.8800  -19.3900
            9   O5a O    21.1400  -21.4900
            10  C8y C    18.6900  -20.0200
            11  C8y C    17.5000  -19.3900
            12  C8y C    16.3100  -20.0900
            13  C8x C    16.3100  -21.4900
            14  C8x C    17.5000  -22.1900
            15  C8x C    18.6900  -21.4200
            16  O2a O    25.9700  -17.2200
            17  C1b C    27.2300  -17.9200
            18  C1b C    28.4200  -17.2200
            19  C1b C    29.6100  -17.9200
            20  C1b C    30.8700  -17.2200
            21  C8y C    32.0600  -17.9200
            22  C8x C    32.0600  -19.3200
            23  C8x C    33.3200  -20.0900
            24  C8x C    34.5100  -19.3200
            25  C8x C    34.5100  -17.9200
            26  C8x C    33.3200  -17.2200
            27  O2x O    17.5000  -17.9900
            28  C8y C    16.3100  -17.2200
            29  C8x C    15.1200  -17.9900
            30  C8y C    15.1200  -19.3900
            31  C8y C    16.3100  -15.8200
            32  N4x N    17.4300  -15.0500
            33  N5x N    17.0100  -13.7200
            34  N5x N    15.6100  -13.7200
            35  N5x N    15.1900  -15.0500
            36  O5x O    13.8600  -20.0900
BOND        40
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     1   7 1
            8     7   8 1
            9     7   9 2
            10    8  10 1
            11   10  11 2
            12   11  12 1
            13   12  13 2
            14   13  14 1
            15   14  15 2
            16   10  15 1
            17    4  16 1
            18   16  17 1
            19   17  18 1
            20   18  19 1
            21   19  20 1
            22   20  21 1
            23   21  22 2
            24   22  23 1
            25   23  24 2
            26   24  25 1
            27   25  26 2
            28   21  26 1
            29   11  27 1
            30   27  28 1
            31   28  29 2
            32   29  30 1
            33   12  30 1
            34   28  31 1
            35   31  32 1
            36   32  33 1
            37   33  34 2
            38   34  35 1
            39   31  35 2
            40   30  36 2

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