KEGG   DRUG: D08422Help
Entry
D08422                      Drug                                   

Name
Procaine (INN);
Solution of novocain (TN)
Formula
C13H20N2O2
Exact mass
236.1525
Mol weight
236.3101
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Local anesthetic
Remark
Same as: 
ATC code: 
Drug group: 
Target
voltage-gated potassium channel (KCNK5) blocker [HSA:8645] [KO:K04916];
voltage-gated sodium channel (SCN10A) blocker [HSA:6336] [KO:K04842];
voltage-gated sodium channel (SCN1A) blocker [HSA:6323] [KO:K04833];
voltage-gated sodium channel (SCN2A) blocker [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN3A) blocker [HSA:6328] [KO:K04836];
voltage-gated sodium channel (SCN4A) blocker [HSA:6329] [KO:K04837];
voltage-gated sodium channel (SCN5A) blocker [HSA:6331] [KO:K04838];
voltage-gated sodium channel (SCN8A) blocker [HSA:6334] [KO:K04840];
voltage-gated sodium channel (SCN9A) blocker [HSA:6335] [KO:K04841];
ryanodine receptor antagonist [HSA:6261 6262 6263] [KO:K04961 K04962 K04963]
Interaction
Drug interaction
Structure map
Local analgesics
Antiarrhythmic drugs
Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AD Local anesthetics
     C05AD05 Procaine
      D08422  Procaine (INN)
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01B ANESTHETICS, LOCAL
    N01BA Esters of aminobenzoic acid
     N01BA02 Procaine
      D08422  Procaine (INN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01H LOCAL ANESTHETICS
    S01HA Local anesthetics
     S01HA05 Procaine
      D08422  Procaine (INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Procaine
    D08422  Procaine (INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ryanodine and IP3 receptors
   Ryanodine receptor (RYR)
    ryanodine receptor (RYR1)
     Procaine
      D08422  Procaine (INN)
    ryanodine receptor (RYR2)
     Procaine
      D08422  Procaine (INN)
    ryanodine receptor (RYR3)
     Procaine
      D08422  Procaine (INN)
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Procaine
      D08422  Procaine (INN)
    voltage-gated sodium channel (SCN2A)
     Procaine
      D08422  Procaine (INN)
    voltage-gated sodium channel (SCN3A)
     Procaine
      D08422  Procaine (INN)
    voltage-gated sodium channel (SCN4A)
     Procaine
      D08422  Procaine (INN)
    voltage-gated sodium channel (SCN5A)
     Procaine
      D08422  Procaine (INN)
    voltage-gated sodium channel (SCN8A)
     Procaine
      D08422  Procaine (INN)
    voltage-gated sodium channel (SCN9A)
     Procaine
      D08422  Procaine (INN)
    voltage-gated sodium channel (SCN10A)
     Procaine
      D08422  Procaine (INN)
   K+ channel, KCNK, K2px.x
    voltage-gated potassium channel (KCNK5)
     Procaine
      D08422  Procaine (INN)
BRITE hierarchy
Other DBs
CAS: 
59-46-1
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        17
            1   C8y C    21.7000  -17.5700
            2   C7a C    22.9600  -18.2700
            3   C8x C    21.7000  -16.1700
            4   C8x C    20.5100  -18.2700
            5   O7a O    24.1500  -17.5700
            6   O6a O    22.9600  -19.6700
            7   C8x C    20.5100  -15.4700
            8   C8x C    19.3200  -17.5700
            9   C1b C    25.3400  -18.2700
            10  C8y C    19.3200  -16.1700
            11  C1b C    26.6000  -17.5700
            12  N1a N    18.0600  -15.4700
            13  N1c N    27.7900  -18.2700
            14  C1b C    28.9800  -17.5700
            15  C1b C    27.7900  -19.6700
            16  C1a C    30.2400  -18.2700
            17  C1a C    28.9800  -20.3700
BOND        17
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     3   7 2
            7     4   8 1
            8     5   9 1
            9     7  10 1
            10    9  11 1
            11   10  12 1
            12   11  13 1
            13   13  14 1
            14   13  15 1
            15   14  16 1
            16   15  17 1
            17    8  10 2

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