KEGG   DRUG: D08428Help
Entry
D08428                      Drug                                   

Name
Proguanil (INN)
Formula
C11H16ClN5
Exact mass
253.1094
Mol weight
253.7312
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiprotozoal, antimalarial [DS:H00361]
Remark
Same as: 
ATC code: 
Drug group: 
Target
dihydrofolate reductase inhibitor [KO:K13998]
  Pathway
ko00240  Pyrimidine metabolism
ko00670  One carbon pool by folate
ko00790  Folate biosynthesis  
 
Metabolism
Enzyme: CYP2C19 [HSA:1557]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 P ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
  P01 ANTIPROTOZOALS
   P01B ANTIMALARIALS
    P01BB Biguanides
     P01BB01 Proguanil
      D08428  Proguanil (INN)
Antiinfectives [BR:br08307]
 Antiparasitics
  Antmalarials
   dihydrofolate reductase inhibitor
    Biguanides
     Proguanil
      D08428  Proguanil (INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2C19
   Proguanil
    D08428  Proguanil (INN)
BRITE hierarchy
Other DBs
CAS: 
500-92-5
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        17
            1   C8x C    14.4565  -16.1592
            2   C8y C    14.4565  -17.5634
            3   C8x C    15.6725  -18.2655
            4   C8x C    16.8887  -17.5634
            5   C8y C    16.8887  -16.1592
            6   C8x C    15.6725  -15.4571
            7   X   Cl   13.2404  -18.2655
            8   N1b N    18.1235  -15.4461
            9   C2c C    19.3323  -16.1439
            10  N1b N    20.5181  -15.4590
            11  N2a N    19.3327  -17.5630
            12  C2c C    21.7157  -16.1504
            13  N1b N    22.9072  -15.4623
            14  N2a N    21.7159  -17.5631
            15  C1c C    24.1019  -16.1521
            16  C1a C    25.2902  -15.4661
            17  C1a C    24.1021  -17.5698
BOND        17
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     2   7 1
            8     5   8 1
            9     8   9 1
            10    9  10 1
            11    9  11 2
            12   10  12 1
            13   12  13 1
            14   12  14 2
            15   13  15 1
            16   15  16 1
            17   15  17 1

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