KEGG   DRUG: ProguanilHelp
Entry
D08428                      Drug                                   

Name
Proguanil (INN)
Formula
C11H16ClN5
Exact mass
253.1094
Mol weight
253.7312
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antiparasitic
 DG01932  Antifolate, antiprotozoal
Cyp substrate
 DG01639  CYP2C19 substrate
Remark
Same as: 
ATC code: 
Chemical group: 
Activity
Antimalarial
Comment
Biguanide
Target
dihydrofolate reductase [KO:K13998]
  Pathway
Pyrimidine metabolism
One carbon pool by folate
Folate biosynthesis
Metabolism
Enzyme: CYP2C19 [HSA:1557]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 P ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
  P01 ANTIPROTOZOALS
   P01B ANTIMALARIALS
    P01BB Biguanides
     P01BB01 Proguanil
      D08428  Proguanil (INN)
Antiinfectives [BR:br08307]
 Antiparasitics
  Antmalarials
   dihydrofolate reductase inhibitor
    Biguanides
     Proguanil
      D08428  Proguanil (INN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP2C19
   Proguanil
    D08428  Proguanil (INN)
BRITE hierarchy
Other DBs
CAS: 
500-92-5
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        17
            1   C8x C    14.4565  -16.1592
            2   C8y C    14.4565  -17.5634
            3   C8x C    15.6725  -18.2655
            4   C8x C    16.8887  -17.5634
            5   C8y C    16.8887  -16.1592
            6   C8x C    15.6725  -15.4571
            7   X   Cl   13.2404  -18.2655
            8   N1b N    18.1235  -15.4461
            9   C2c C    19.3323  -16.1439
            10  N1b N    20.5181  -15.4590
            11  N2a N    19.3327  -17.5630
            12  C2c C    21.7157  -16.1504
            13  N1b N    22.9072  -15.4623
            14  N2a N    21.7159  -17.5631
            15  C1c C    24.1019  -16.1521
            16  C1a C    25.2902  -15.4661
            17  C1a C    24.1021  -17.5698
BOND        17
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     2   7 1
            8     5   8 1
            9     8   9 1
            10    9  10 1
            11    9  11 2
            12   10  12 1
            13   12  13 1
            14   12  14 2
            15   13  15 1
            16   15  16 1
            17   15  17 1

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