KEGG   DRUG: PropiverineHelp
Entry
D08441                      Drug                                   

Name
Propiverine (INN)
Formula
C23H29NO3
Exact mass
367.2147
Mol weight
367.4813
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01491  Muscarinic cholinergic receptor antagonist
Cyp substrate
 DG01633  CYP3A substrate
Remark
Same as: 
ATC code: 
Chemical group: 
Efficacy
Antipollakisuria, Overactive bladder agent, Muscarinic acetylcholine receptor antagonist
Target
CHRM [HSA:1128 1129 1131 1132 1133] [KO:K04129 K04130 K04131 K04132 K04133]
CACNA1C [HSA:775] [KO:K04850]
CACNA1D [HSA:776] [KO:K04851]
CACNA1F [HSA:778] [KO:K04853]
CACNA1S [HSA:779] [KO:K04857]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Cholinergic and anticholinergic drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G04 UROLOGICALS
   G04B UROLOGICALS
    G04BD Urinary antispasmodics
     G04BD06 Propiverine
      D08441  Propiverine (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    muscarinic cholinergic receptor
     Propiverine
      D08441  Propiverine (INN)
 Ion channels
  Voltage-gated cation channels
   Ca2+ channel, CACN alpha-1, CaVx.x
    calcium channel L type
     Propiverine
      D08441  Propiverine (INN)
BRITE hierarchy
Other DBs
CAS: 
60569-19-9
PubChem: 
ChEBI: 
ChEMBL: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        27
            1   C1x C    19.3200  -19.3200
            2   N1y N    19.3200  -20.7200
            3   C1x C    20.5100  -21.4200
            4   C1x C    21.7700  -20.7200
            5   C1y C    21.7700  -19.3200
            6   C1x C    20.5100  -18.6200
            7   O7a O    22.9600  -18.6200
            8   C7a C    24.1500  -19.3200
            9   C1d C    25.4100  -18.6200
            10  C8y C    26.6000  -19.3200
            11  C8x C    27.7900  -18.6200
            12  C8x C    29.0500  -19.3200
            13  C8y C    25.4100  -17.2200
            14  C8x C    26.6000  -16.5200
            15  C8x C    26.6000  -15.1200
            16  C8x C    25.4100  -14.4200
            17  C8x C    24.1500  -15.1200
            18  C8x C    24.1500  -16.5200
            19  C8x C    26.6000  -20.7200
            20  C8x C    27.7900  -21.4200
            21  C8x C    29.0500  -20.7200
            22  O2a O    26.6000  -17.9200
            23  C1b C    27.7900  -17.2200
            24  C1b C    29.0500  -17.9200
            25  C1a C    30.2400  -17.2200
            26  O6a O    24.1500  -20.7200
            27  C1a C    18.1300  -21.4200
BOND        29
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 2
            13    9  13 1
            14   13  14 1
            15   14  15 2
            16   15  16 1
            17   16  17 2
            18   17  18 1
            19   13  18 2
            20   10  19 2
            21   19  20 1
            22   20  21 2
            23   21  12 1
            24    9  22 1
            25   22  23 1
            26   23  24 1
            27   24  25 1
            28    8  26 2
            29    2  27 1

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