KEGG   DRUG: QuinidineHelp
Entry
D08458                      Drug                                   

Name
Quinidine (BAN);
Kinidin (TN)
Formula
C20H24N2O2
Exact mass
324.1838
Mol weight
324.4168
Structure
Mol fileKCF fileDB searchJmolKegDraw
Source
Cinchona calisaya [TAX:153742], Cinchona succirubra, Cinchona calisaya
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01652  Class I antiarrhythmic agent
   DG01649  Class Ia antiarrhythmic agent
Cyp substrate
 DG01633  CYP3A substrate
Cyp inhibitor
 DG01645  CYP2D6 inhibitor
Remark
Same as: 
ATC code: 
Chemical group: 
Activity
Antiarrhythmic, Antimalarial, Sodium channel blocker
Comment
Class I antiarrhythmic agent (Ia)
Cinchona lkaloid
Target
SCN1A [HSA:6323] [KO:K04833];
SCN2A [HSA:6326] [KO:K04834];
SCN3A [HSA:6328] [KO:K04836];
SCN4A [HSA:6329] [KO:K04837];
SCN5A [HSA:6331] [KO:K04838];
SCN8A [HSA:6334] [KO:K04840];
SCN9A [HSA:6335] [KO:K04841]
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Transporter: SLC22A1 [HSA:6580], SLC22A3 [HSA:6581]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
CYP inhibition: CYP2D6 [HSA:1565]
Transporter inhibition: SLC22A2 [HSA:6582], SLC22A1 [HSA:6580], SLC47A1 [HSA:55244], SCL47A2 [HSA:146802], ABCB1 [HSA:5243]
Drug interaction
Structure map
Quinolines
Antiarrhythmic drugs
Sodium channel blocking drugs
Other map
Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BA Antiarrhythmics, class Ia
     C01BA01 Quinidine
      D08458  Quinidine (BAN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Antiarrhythmics
   Quinidine
    D08458  Quinidine (BAN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Quinidine
      D08458  Quinidine (BAN)
    voltage-gated sodium channel (SCN2A)
     Quinidine
      D08458  Quinidine (BAN)
    voltage-gated sodium channel (SCN3A)
     Quinidine
      D08458  Quinidine (BAN)
    voltage-gated sodium channel (SCN4A)
     Quinidine
      D08458  Quinidine (BAN)
    voltage-gated sodium channel (SCN5A)
     Quinidine
      D08458  Quinidine (BAN)
    voltage-gated sodium channel (SCN8A)
     Quinidine
      D08458  Quinidine (BAN)
    voltage-gated sodium channel (SCN9A)
     Quinidine
      D08458  Quinidine (BAN)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP2D6
   Quinidine
    D08458  Quinidine (BAN)
 CYP substrates
  CYP3A4
   Quinidine
    D08458  Quinidine (BAN)
  CYP3A
   Quinidine
    D08458  Quinidine (BAN)
 Transporter inhibitors
  ABCB1
   Quinidine
    D08458  Quinidine (BAN)
  SLC22A1
   Quinidine
    D08458  Quinidine (BAN)
  SLC22A2
   Quinidine
    D08458  Quinidine (BAN)
  MATE1
   Quinidine
    D08458  Quinidine (BAN)
  MATE2
   Quinidine
    D08458  Quinidine (BAN)
 Transporter substrates
  ABCB1
   Quinidine
    D08458  Quinidine (BAN)
  SLC22A1
   Quinidine
    D08458  Quinidine (BAN)
  SLC22A3
   Quinidine
    D08458  Quinidine (BAN)
Phytochemicals used as drugs [BR:br08306]
 Alkaloids
  Alkaloids derived from tryptophan and anthranillic acid
   Quinoline alkaloids
    D08458  Quinidine (BAN)
BRITE hierarchy
Other DBs
CAS: 
56-54-2
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        24
            1   C8y C    25.2071  -26.8235
            2   C8y C    26.4637  -26.1254
            3   C8y C    25.2071  -28.2197
            4   C8x C    24.0203  -26.1254
            5   C1c C    26.4637  -24.7292
            6   C8x C    27.6505  -26.8235
            7   C8x C    24.0203  -28.9178
            8   N5x N    26.3939  -28.9178
            9   C8y C    22.7637  -26.8235
            10  C1y C    27.6505  -24.0311
            11  O1a O    25.2071  -24.0311
            12  C8x C    27.6505  -28.2197
            13  C8x C    22.7637  -28.2197
            14  O2a O    21.5769  -26.1254
            15  N1y N    29.1165  -23.1235
            16  C1x C    26.9524  -22.9839
            17  C1a C    21.5769  -24.7292
            18  C1x C    29.1165  -21.8669
            19  C1x C    30.5825  -23.9613
            20  C1y C    28.3486  -22.1462
            21  C1y C    28.3486  -21.1688
            22  C1x C    29.8844  -22.8443
            23  C2b C    27.7901  -19.8424
            24  C2a C    28.6976  -18.7254
BOND        27
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     3   8 1
            8     4   9 2
            9     5  10 1
            10    5  11 1 #Down
            11    6  12 1
            12    7  13 2
            13    9  14 1
            14   10  15 1
            15   10  16 1
            16   14  17 1
            17   15  18 1
            18   15  19 1
            19   16  20 1
            20   18  21 1
            21   19  22 1
            22   21  23 1 #Up
            23   23  24 2
            24    8  12 2
            25    9  13 1
            26   20  21 1
            27   20  22 1

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