KEGG   DRUG: RopivacaineHelp
Entry
D08490                      Drug                                   

Name
Ropivacaine (INN);
Naropin (TN)
Formula
C17H26N2O
Exact mass
274.2045
Mol weight
274.4011
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Neuropsychiatric agent
 DG01675  Local anesthetic
  DG01673  Amide type local anesthetic
Cyp substrate
 DG01892  CYP1A2 substrate
Remark
Same as: 
ATC code: 
Chemical group: 
Activity
Anesthetic (local)
Target
SCN10A [HSA:6336] [KO:K04842];
SCN1A [HSA:6323] [KO:K04833];
SCN2A [HSA:6326] [KO:K04834];
SCN3A [HSA:6328] [KO:K04836];
SCN4A [HSA:6329] [KO:K04837];
SCN5A [HSA:6331] [KO:K04838];
SCN8A [HSA:6334] [KO:K04840];
SCN9A [HSA:6335] [KO:K04841]
Metabolism
Enzyme: CYP1A2 [HSA:1544]
Interaction
Drug interaction
Structure map
Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01B ANESTHETICS, LOCAL
    N01BB Amides
     N01BB09 Ropivacaine
      D08490  Ropivacaine (INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Ropivacaine
      D08490  Ropivacaine (INN)
    voltage-gated sodium channel (SCN2A)
     Ropivacaine
      D08490  Ropivacaine (INN)
    voltage-gated sodium channel (SCN3A)
     Ropivacaine
      D08490  Ropivacaine (INN)
    voltage-gated sodium channel (SCN4A)
     Ropivacaine
      D08490  Ropivacaine (INN)
    voltage-gated sodium channel (SCN5A)
     Ropivacaine
      D08490  Ropivacaine (INN)
    voltage-gated sodium channel (SCN8A)
     Ropivacaine
      D08490  Ropivacaine (INN)
    voltage-gated sodium channel (SCN9A)
     Ropivacaine
      D08490  Ropivacaine (INN)
    voltage-gated sodium channel (SCN10A)
     Ropivacaine
      D08490  Ropivacaine (INN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP1A2
   Ropivacaine
    D08490  Ropivacaine (INN)
BRITE hierarchy
Other DBs
CAS: 
84057-95-4
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        20
            1   C1y C    26.9298  -19.4988
            2   N1y N    26.9298  -20.8966
            3   C5a C    25.7416  -18.7999
            4   C1x C    28.1878  -18.7999
            5   C1x C    28.1178  -21.6653
            6   C1b C    25.6718  -21.5954
            7   N1b N    24.4836  -19.4988
            8   O5a O    25.7421  -17.6817
            9   C1x C    29.3758  -19.4988
            10  C1x C    29.3754  -20.9665
            11  C8y C    23.2956  -18.6602
            12  C8y C    22.0376  -19.3590
            13  C8y C    23.2956  -17.2624
            14  C8x C    20.7795  -18.6602
            15  C1a C    22.0376  -20.6869
            16  C8x C    22.0376  -16.5634
            17  C1a C    24.4836  -16.5634
            18  C8x C    20.7795  -17.2624
            19  C1b C    24.4938  -20.9026
            20  C1a C    23.2688  -21.5965
BOND        21
            1     1   2 1
            2     1   3 1 #Down
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 2
            8     4   9 1
            9     5  10 1
            10    7  11 1
            11   11  12 2
            12   11  13 1
            13   12  14 1
            14   12  15 1
            15   13  16 2
            16   13  17 1
            17   14  18 2
            18    9  10 1
            19   16  18 1
            20    6  19 1
            21   19  20 1

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