KEGG   DRUG: D08490Help
Entry
D08490                      Drug                                   

Name
Ropivacaine (INN);
Naropin (TN)
Formula
C17H26N2O
Exact mass
274.2045
Mol weight
274.4011
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Local anesthetic
Remark
Same as: 
ATC code: 
Drug group: 
Target
voltage-gated sodium channel (SCN10A) blocker [HSA:6336] [KO:K04842];
voltage-gated sodium channel (SCN1A) blocker [HSA:6323] [KO:K04833];
voltage-gated sodium channel (SCN2A) blocker [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN3A) blocker [HSA:6328] [KO:K04836];
voltage-gated sodium channel (SCN4A) blocker [HSA:6329] [KO:K04837];
voltage-gated sodium channel (SCN5A) blocker [HSA:6331] [KO:K04838];
voltage-gated sodium channel (SCN8A) blocker [HSA:6334] [KO:K04840];
voltage-gated sodium channel (SCN9A) blocker [HSA:6335] [KO:K04841]
Metabolism
Enzyme: CYP1A2 [HSA:1544]
Interaction
Drug interaction
Structure map
Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01B ANESTHETICS, LOCAL
    N01BB Amides
     N01BB09 Ropivacaine
      D08490  Ropivacaine (INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Ropivacaine
      D08490  Ropivacaine (INN)
    voltage-gated sodium channel (SCN2A)
     Ropivacaine
      D08490  Ropivacaine (INN)
    voltage-gated sodium channel (SCN3A)
     Ropivacaine
      D08490  Ropivacaine (INN)
    voltage-gated sodium channel (SCN4A)
     Ropivacaine
      D08490  Ropivacaine (INN)
    voltage-gated sodium channel (SCN5A)
     Ropivacaine
      D08490  Ropivacaine (INN)
    voltage-gated sodium channel (SCN8A)
     Ropivacaine
      D08490  Ropivacaine (INN)
    voltage-gated sodium channel (SCN9A)
     Ropivacaine
      D08490  Ropivacaine (INN)
    voltage-gated sodium channel (SCN10A)
     Ropivacaine
      D08490  Ropivacaine (INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP1A2
   Ropivacaine
    D08490  Ropivacaine (INN)
BRITE hierarchy
Other DBs
CAS: 
84057-95-4
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        20
            1   C1y C    26.9298  -19.4988
            2   N1y N    26.9298  -20.8966
            3   C5a C    25.7416  -18.7999
            4   C1x C    28.1878  -18.7999
            5   C1x C    28.1178  -21.6653
            6   C1b C    25.6718  -21.5954
            7   N1b N    24.4836  -19.4988
            8   O5a O    25.7421  -17.6817
            9   C1x C    29.3758  -19.4988
            10  C1x C    29.3754  -20.9665
            11  C8y C    23.2956  -18.6602
            12  C8y C    22.0376  -19.3590
            13  C8y C    23.2956  -17.2624
            14  C8x C    20.7795  -18.6602
            15  C1a C    22.0376  -20.6869
            16  C8x C    22.0376  -16.5634
            17  C1a C    24.4836  -16.5634
            18  C8x C    20.7795  -17.2624
            19  C1b C    24.4938  -20.9026
            20  C1a C    23.2688  -21.5965
BOND        21
            1     1   2 1
            2     1   3 1 #Down
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 2
            8     4   9 1
            9     5  10 1
            10    7  11 1
            11   11  12 2
            12   11  13 1
            13   12  14 1
            14   12  15 1
            15   13  16 2
            16   13  17 1
            17   14  18 2
            18    9  10 1
            19   16  18 1
            20    6  19 1
            21   19  20 1

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