KEGG   DRUG: RosiglitazoneHelp
Entry
D08491                      Drug                                   

Name
Rosiglitazone (INN);
Gaudil (TN)
Formula
C18H19N3O3S
Exact mass
357.1147
Mol weight
357.4268
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antidiabetic agent
 DG01685  Insulin sensitizer
  DG01795  PPAR gamma agonist
   DG01683  Thiazolidinedione
Other
 DG01733  PPAR agonist
  DG01683  Thiazolidinedione
Remark
ATC code: 
Chemical group: 
Activity
Antidiabetic
Target
peroxisome proliferator-activated receptor (PPAR) gamma [HSA:5468] [KO:K08530]
  Pathway
PPAR signaling pathway
Metabolism
Enzyme: CYP2C8 [HSA:1558], CYP2C9 [HSA:1559]
Interaction
Drug interaction
Structure map
Peroxisome proliferator-activated receptor (PPAR) agonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BG Thiazolidinediones
     A10BG02 Rosiglitazone
      D08491  Rosiglitazone (INN)
USP drug classification [BR:br08302]
 Blood Glucose Regulators
  Antidiabetic Agents
   Rosiglitazone
    D08491  Rosiglitazone (INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Thyroid hormone like receptors
   Peroxisome proliferator-activated receptor (PPAR)
    peroxisome proliferator-activated receptor (PPAR) gamma
     Rosiglitazone
      D08491  Rosiglitazone (INN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP2C8
   Rosiglitazone
    D08491  Rosiglitazone (INN)
  CYP2C9
   Rosiglitazone
    D08491  Rosiglitazone (INN)
BRITE hierarchy
Other DBs
CAS: 
122320-73-4
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        25
            1   C1y C    29.0500  -16.1000
            2   C1b C    27.8600  -15.4700
            3   S2x S    30.3800  -15.6800
            4   C5x C    29.0500  -17.5700
            5   C8y C    26.6000  -16.1000
            6   C5x C    31.2200  -16.8000
            7   N1x N    30.3800  -17.9900
            8   O5x O    27.9300  -18.4100
            9   C8x C    25.4100  -15.4700
            10  C8x C    26.6000  -17.5700
            11  O5x O    32.6200  -16.8000
            12  C8x C    24.2200  -16.1000
            13  C8x C    25.4100  -18.2000
            14  C8y C    24.2200  -17.5700
            15  O2a O    22.9600  -18.2000
            16  C1b C    21.7700  -17.5700
            17  C1b C    20.5800  -18.2000
            18  N1c N    19.3900  -17.5700
            19  C8y C    18.1300  -18.2000
            20  C1a C    19.3900  -16.1000
            21  C8x C    18.1300  -19.6700
            22  N5x N    16.9400  -17.5700
            23  C8x C    16.9400  -20.3700
            24  C8x C    15.7500  -18.2700
            25  C8x C    15.7500  -19.6700
BOND        27
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     4   7 1
            7     4   8 2
            8     5   9 2
            9     5  10 1
            10    6  11 2
            11    9  12 1
            12   10  13 2
            13   12  14 2
            14   14  15 1
            15   15  16 1
            16   16  17 1
            17   17  18 1
            18   18  19 1
            19   18  20 1
            20   19  21 1
            21   19  22 2
            22   21  23 2
            23   22  24 1
            24   23  25 1
            25    6   7 1
            26   13  14 1
            27   24  25 2

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