KEGG   DRUG: D08492Help
Entry
D08492                      Drug                                   

Name
Rosuvastatin (INN);
Creston (TN)
Formula
C22H28FN3O6S
Exact mass
481.1683
Mol weight
481.5376
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihyperlipidemic
Remark
ATC code: 
Drug group: 
Target
hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitor [HSA:3156] [KO:K00021]
  Pathway
hsa00900  Terpenoid backbone biosynthesis  
 
Metabolism
Transporter: ABCG2 [HSA:9429], SLCO1B1 [HSA:10599], SLCO1B3 [HSA:28234], SLC22A8 [HSA:9376]
Interaction
Genomic biomarker: LDLR [HSA:3949]
Drug interaction
Structure map
HMG-CoA reductase inhibitors
Other map
Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C10 LIPID MODIFYING AGENTS
   C10A LIPID MODIFYING AGENTS, PLAIN
    C10AA HMG CoA reductase inhibitors
     C10AA07 Rosuvastatin
      D08492  Rosuvastatin (INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Dyslipidemics, HMG CoA Reductase Inhibitors
   Rosuvastatin
    D08492  Rosuvastatin (INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases
   hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase
    Rosuvastatin
     D08492  Rosuvastatin (INN)
BRITE hierarchy
Other DBs
CAS: 
287714-41-4
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        33
            1   C8y C    24.1500  -19.4600
            2   N5x N    24.1500  -20.8600
            3   C8y C    25.3400  -21.5600
            4   N5x N    26.6000  -20.8600
            5   C8y C    26.6000  -19.4600
            6   C8y C    25.3400  -18.7600
            7   C1c C    27.7900  -18.7600
            8   C1a C    28.9800  -19.4600
            9   C1a C    27.7900  -17.3600
            10  C2b C    25.3400  -17.3600
            11  C2b C    26.6000  -16.6600
            12  C1c C    26.6000  -15.2600
            13  O1a O    27.7900  -14.5600
            14  C1b C    25.3400  -14.5600
            15  C1c C    25.3400  -13.1600
            16  O1a O    24.1500  -12.4600
            17  C1b C    26.6000  -12.4600
            18  C6a C    28.0000  -12.4600
            19  O6a O    28.7000  -11.2700
            20  O6a O    28.7000  -13.6500
            21  N1c N    25.3400  -22.9600
            22  S4a S    26.6000  -23.6600
            23  C1a C    24.1500  -23.6600
            24  C1a C    27.7900  -22.9600
            25  O3c O    25.6200  -24.6400
            26  O3c O    27.5800  -24.6400
            27  C8y C    22.9600  -18.7600
            28  C8x C    22.9600  -17.3600
            29  C8x C    21.7000  -16.6600
            30  C8y C    20.5100  -17.3600
            31  C8x C    20.5100  -18.7600
            32  C8x C    21.7000  -19.4600
            33  X   F    19.3200  -16.6600
BOND        34
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     7   9 1
            10    6  10 1
            11   10  11 2
            12   12  11 1 #Down
            13   12  13 1
            14   12  14 1
            15   14  15 1
            16   15  16 1 #Up
            17   15  17 1
            18   17  18 1
            19   18  19 2
            20   18  20 1
            21    3  21 1
            22   21  22 1
            23   21  23 1
            24   22  24 1
            25   22  25 2
            26   22  26 2
            27    1  27 1
            28   27  28 2
            29   28  29 1
            30   29  30 2
            31   30  31 1
            32   31  32 2
            33   27  32 1
            34   30  33 1

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