KEGG   DRUG: RosuvastatinHelp
Entry
D08492                      Drug                                   

Name
Rosuvastatin (INN);
Creston (TN)
Formula
C22H28FN3O6S
Exact mass
481.1683
Mol weight
481.5376
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01660  HMG-CoA reductase inhibitor
  DG01660  HMG-CoA reductase inhibitor
Transporter substrate
 DG01913  BCRP substrate
Remark
ATC code: 
Chemical group: 
Activity
Antihyperlipidemic, HMG-CoA reductase inhibitor
Target
HMGCR [HSA:3156] [KO:K00021]
  Pathway
Terpenoid backbone biosynthesis
Metabolism
Transporter: ABCG2 [HSA:9429], SLCO1B1 [HSA:10599], SLCO1B3 [HSA:28234], SLC22A8 [HSA:9376]
Interaction
Genomic biomarker: LDLR [HSA:3949]
Drug interaction
Structure map
HMG-CoA reductase inhibitors
Other map
Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C10 LIPID MODIFYING AGENTS
   C10A LIPID MODIFYING AGENTS, PLAIN
    C10AA HMG CoA reductase inhibitors
     C10AA07 Rosuvastatin
      D08492  Rosuvastatin (INN)
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Dyslipidemics, HMG CoA Reductase Inhibitors
   Rosuvastatin
    D08492  Rosuvastatin (INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases
   hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase
    Rosuvastatin
     D08492  Rosuvastatin (INN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP3A
   Rosuvastatin
    D08492  Rosuvastatin (INN)
 Transporter substrates
  ABCG2
   Rosuvastatin
    D08492  Rosuvastatin (INN)
  OAT3
   Rosuvastatin
    D08492  Rosuvastatin (INN)
  SLCO1B1
   Rosuvastatin
    D08492  Rosuvastatin (INN)
  SLCO1B3
   Rosuvastatin
    D08492  Rosuvastatin (INN)
BRITE hierarchy
Other DBs
CAS: 
287714-41-4
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        33
            1   C8y C    24.1500  -19.4600
            2   N5x N    24.1500  -20.8600
            3   C8y C    25.3400  -21.5600
            4   N5x N    26.6000  -20.8600
            5   C8y C    26.6000  -19.4600
            6   C8y C    25.3400  -18.7600
            7   C1c C    27.7900  -18.7600
            8   C1a C    28.9800  -19.4600
            9   C1a C    27.7900  -17.3600
            10  C2b C    25.3400  -17.3600
            11  C2b C    26.6000  -16.6600
            12  C1c C    26.6000  -15.2600
            13  O1a O    27.7900  -14.5600
            14  C1b C    25.3400  -14.5600
            15  C1c C    25.3400  -13.1600
            16  O1a O    24.1500  -12.4600
            17  C1b C    26.6000  -12.4600
            18  C6a C    28.0000  -12.4600
            19  O6a O    28.7000  -11.2700
            20  O6a O    28.7000  -13.6500
            21  N1c N    25.3400  -22.9600
            22  S4a S    26.6000  -23.6600
            23  C1a C    24.1500  -23.6600
            24  C1a C    27.7900  -22.9600
            25  O3c O    25.6200  -24.6400
            26  O3c O    27.5800  -24.6400
            27  C8y C    22.9600  -18.7600
            28  C8x C    22.9600  -17.3600
            29  C8x C    21.7000  -16.6600
            30  C8y C    20.5100  -17.3600
            31  C8x C    20.5100  -18.7600
            32  C8x C    21.7000  -19.4600
            33  X   F    19.3200  -16.6600
BOND        34
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     7   9 1
            10    6  10 1
            11   10  11 2
            12   12  11 1 #Down
            13   12  13 1
            14   12  14 1
            15   14  15 1
            16   15  16 1 #Up
            17   15  17 1
            18   17  18 1
            19   18  19 2
            20   18  20 1
            21    3  21 1
            22   21  22 1
            23   21  23 1
            24   22  24 1
            25   22  25 2
            26   22  26 2
            27    1  27 1
            28   27  28 2
            29   28  29 1
            30   29  30 2
            31   30  31 1
            32   31  32 2
            33   27  32 1
            34   30  33 1

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