KEGG   DRUG: D08503Help
Entry
D08503                      Drug                                   

Name
Toceranib (USAN)
Formula
C22H25FN4O2
Exact mass
396.1962
Mol weight
396.4579
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Treatment of mast cell tumors in dogs, veterinary
Comment
Tyrosine kinase inhibitor
angiogenesis inhibitor
Target
c-KIT tyrosine kinase inhibitor [HSA:3815] [KO:K05091];
VEGFR1 tyrosine kinase inhibitor [HSA:2321] [KO:K05096];
VEGFR2 tyrosine kinase inhibitor [HSA:3791] [KO:K05098];
PDGFRA tyrosine kinase inhibitor [HSA:5156] [KO:K04363];
PDGFRB tyrosine kinase inhibitor [HSA:5159] [KO:K05089];
VEGFR3 tyrosine kinase inhibitor [HSA:2324] [KO:K05097];
FLT3 inhibitor [HSA:2322] [KO:K05092]
  Pathway
hsa04010  MAPK signaling pathway
hsa04020  Calcium signaling pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04151  PI3K-Akt signaling pathway
hsa04370  VEGF signaling pathway
hsa04510  Focal adhesion  
 
Brite
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Receptor tyrosine kinase
   RTK class III (PDGF receptor family)
    PDGFRA tyrosine kinase
     Toceranib
      D08503  Toceranib (USAN)
    PDGFRB tyrosine kinase
     Toceranib
      D08503  Toceranib (USAN)
    c-KIT tyrosine kinase
     Toceranib
      D08503  Toceranib (USAN)
   RTK class V (VEGF receptor family)
    VEGFR1 tyrosine kinase
     Toceranib
      D08503  Toceranib (USAN)
    VEGFR2 tyrosine kinase
     Toceranib
      D08503  Toceranib (USAN)
    VEGFR3 tyrosine kinase
     Toceranib
      D08503  Toceranib (USAN)
BRITE hierarchy
Other DBs
CAS: 
356068-94-5
PubChem: 
LigandBox: 
KCF data Show

ATOM        29
            1   C8x C    17.1500   -5.8800
            2   C8x C    15.9600   -6.5800
            3   C8y C    15.9600   -7.9800
            4   C8x C    17.1500   -8.6800
            5   C8y C    18.3400   -7.9800
            6   C8y C    18.3400   -6.5800
            7   C2y C    19.7400   -8.4000
            8   C5x C    20.5100   -7.2800
            9   N1x N    19.7400   -6.1600
            10  X   F    14.7700   -8.6800
            11  O5x O    21.9100   -7.2800
            12  C2b C    19.7400   -9.8000
            13  C8y C    20.9300  -10.5000
            14  C8y C    20.9300  -11.9000
            15  C8y C    22.2600  -12.3200
            16  C8y C    23.0300  -11.2000
            17  N4x N    22.2600  -10.0800
            18  C1a C    19.7400  -12.7400
            19  C1a C    24.5000  -11.2000
            20  C5a C    22.2600  -13.7900
            21  O5a O    21.0700  -14.4900
            22  N1b N    23.5200  -14.4900
            23  C1b C    24.7100  -13.7900
            24  C1b C    25.9000  -14.4900
            25  N1y N    27.0900  -13.7900
            26  C1x C    28.4247  -14.2127
            27  C1x C    29.2391  -13.0740
            28  C1x C    28.4078  -11.9475
            29  C1x C    27.0796  -12.3900
BOND        32
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 1
            10    6   9 1
            11    3  10 1
            12    8  11 2
            13    7  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17   15  16 2
            18   16  17 1
            19   13  17 1
            20   14  18 1
            21   16  19 1
            22   15  20 1
            23   20  21 2
            24   20  22 1
            25   22  23 1
            26   23  24 1
            27   24  25 1
            28   25  26 1
            29   26  27 1
            30   27  28 1
            31   28  29 1
            32   25  29 1

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