KEGG   DRUG: D08513Help
Entry
D08513                      Drug                                   

Name
Sibutramine (INN);
Butramin (TN)
Formula
C17H26ClN
Exact mass
279.1754
Mol weight
279.848
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anorexic;
Antidepressant
Remark
Same as: 
ATC code: 
Drug group: 
Comment
Serotonin norepinephrine reuptake inhibitor (SNRI)
Target
noradrenalin transporter inhibitor [HSA:6530] [KO:K05035];
dopamine transporter inhibitor [HSA:6531] [KO:K05036];
serotonin transporter inhibitor [HSA:6532] [KO:K05037]
  Pathway
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse  
 
Interaction
Drug interaction
Structure map
Antidepressants
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A08 ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS
   A08A ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS
    A08AA Centrally acting antiobesity products
     A08AA10 Sibutramine
      D08513  Sibutramine (INN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (noradrenalin transporter)
     Sibutramine
      D08513  Sibutramine (INN)
    SLC6A3 (dopamine transporter)
     Sibutramine
      D08513  Sibutramine (INN)
    SLC6A4 (serotonin transporter)
     Sibutramine
      D08513  Sibutramine (INN)
BRITE hierarchy
Other DBs
CAS: 
106650-56-0
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        19
            1   C1z C    16.3100  -20.3700
            2   C8y C    15.1200  -21.0700
            3   C1c C    17.5000  -21.0700
            4   C1x C    17.2900  -19.3900
            5   C1x C    15.3300  -19.3900
            6   C8x C    15.1200  -22.4700
            7   C8x C    13.8600  -20.3700
            8   N1c N    18.7600  -20.3700
            9   C1x C    16.3100  -18.4100
            10  C8x C    13.8600  -23.1700
            11  C8x C    12.6000  -21.0700
            12  C1a C    19.9500  -21.0700
            13  C8y C    12.6000  -22.4700
            14  X   Cl   11.4100  -23.1700
            15  C1a C    18.7772  -18.9701
            16  C1b C    17.4828  -22.4699
            17  C1c C    18.6992  -23.1924
            18  C1a C    19.9226  -22.5061
            19  C1a C    18.6820  -24.5700
BOND        20
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1
            5     2   6 1
            6     2   7 2
            7     3   8 1
            8     4   9 1
            9     6  10 2
            10    7  11 1
            11    8  12 1
            12   10  13 1
            13   13  14 1
            14    5   9 1
            15   11  13 2
            16    8  15 1
            17    3  16 1
            18   16  17 1
            19   17  18 1
            20   17  19 1

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